Blood
Articles in this Issue
ESAM is functionally involved in the activity of cancer stem-like cells in human acute myeloid leukemia
Abstract Despite major advances in molecularly targeted therapies for hematologic malignancies such as CML and malignant lymphoma, effective...
Gut microbiome structure prior to neoadjuvant chemoradiotherapy predicts risk of myelosuppression in rectal cancer patients
Abstract Background The gut microbiome plays a significant role in colorectal cancer development and treatment response. Neoadjuvant chemora...
Real-world outcomes of glofitamab (Glofit) plus gemcitabine and oxaliplatin (GemOx) in Relapsed/Refractory (R/R) aggressive B-cell lymphoma (BCL): A multicenter retrospective study from the United States
Abstract Background: Glofit, a CD20/CD3 bispecific antibody, has shown efficacy in prospective trials, including the Phase III STARGLO study...
Lipid metabolic reprogramming mediated by YTHDF3 deficiency underlies immunotherapy resistance in extranodal NK/T-cell lymphoma
Abstract Background: Extranodal NK/T-cell lymphoma (NKTCL) is an aggressive non-Hodgkin lymphoma subtype. Despite improved outcomes with imm...
AAV gene therapy in hemophilia B shows robust bleeding reduction and variable factor IX expression: A bayesian meta-analysis of randomized controlled trials
Abstract Introduction Hemophilia B, a congenital X-linked bleeding disorder caused by factor IX (FIX) deficiency, poses significant challeng...
Interleukin-12 and TNFα signaling drives parallel evolution of independent leukemic clones in JAK2V617F mutant myeloproliferative neoplasms
Abstract Progression from chronic phase myeloproliferative neoplasm (MPN) to secondary acute myeloid leukemia (sAML) is a poorly understood,...
HSV-1 infection as a rare trigger of methotrexate toxicity: A diagnostic and therapeutic challenge
Abstract Introduction: We present a novel case of severe pancytopenia in a 63-year-old woman receiving low-dose methotre...
Triptonide and bortezomib synergistically inhibit multiple myeloma by enhancing DNA damage through blocking TRIP13-mediated DNA repair
Abstract Background: Multiple myeloma (MM) is a malignant neoplasm of plasma cells. Clinically, the proteasome inhibitor bortezomib (BTZ) in...
A retrospective survival outcomes analysis of acute erythroid leukemia patients treated with upfront 7+3 induction chemotherapy versus hypomethylating agents with venetoclax utilizing real-world data
Abstract Background: Acute erythroid leukemia (AEL) is considered a rare and aggressive subtype of acute myeloid leukemia (AML). There is so...
B-lineage acute lymphoblastic leukaemia disrupts a LepR+ bone marrow stromal niche which is critical for CAR-T cell persistence
Abstract B-lineage acute lymphoblastic leukaemia (B-ALL) is an aggressive haematological malignancy with high treatment failure rates. Whils...
Bone marrow next generation sequencing minimal residual disease (NGS-MRD) positivity pre-allogeneic hematopoietic cell transplantation (HCT) predicts outcomes for patients with B-cell acute lymphoblastic leukemia (B-ALL): A planned analysis from the ptctc ONC1401 trial
Abstract HCT is a well-established standard therapy for children and young adults (CYA) with very high-risk/relapsed B-ALL. Recent studies h...
Artificial intelligence/machine learning-based risk prediction model guiding individualized interventions to improve outcomes for patients with multiple myeloma
Abstract Multiple myeloma (MM) is the second most common hematologic malignancy in the United States, with approximately 32,000 new cases an...
Mitochondrial RNA pseudouridine reprograms metabolism and induces immunosuppression in myeloid leukemia
Abstract Pseudouridine (Ψ) is the most prevalent RNA modification in human cells. Although Ψ was among the first post-transcriptional modifi...
Dual-function engineered bacteria remodel AML tumor microenvironment via IL-12 delivery and adenosine depletion to sustain NK cell immunity
Abstract Background Cellular immunotherapy has revolutionized cancer treatment. Yet its efficacy in acute myeloid leukemia (AML) remains lim...
Large language model for abstraction of CAR-T therapy toxicities data
Abstract Introduction: Reporting patient outcomes by CAR-T treatment centers is part of the accreditation requirement un...
Expanding the boundaries of CAR T-cell therapy: Implementation of an outpatient-at-home (OATH) model
Abstract Background: CAR-T cell immunotherapy represents a major advancement in the treatment of relapsed/refractory (R/R) hematologic malig...
Microbiota-derived 1,5-pentanediamine attenuates CD19 CAR-T function
Abstract Background: Previous studies indicate that bacteremia may compromise CAR-T cell therapy efficacy. However, it remains unclear wheth...
A potential drug to overcome the venetoclax resistance challenge in AML: Mitoxantrone hydrochloride liposome
Abstract The venetoclax combined with azacitidine regimen has greatly improved the prognosis of acute myeloid leukemia (AML). However, appro...
A novel conditioning regimen combining selinexor with melphalan Improves Survival in Patients with multiple myeloma:a prospective study
Abstract Background: High-dose melphalan followed by autologous hematopoietic stem cell transplantation (ASCT) remains the standard consolid...
Outcomes for black persons with multiple myeloma: A national retrospective trend analysis from 2015 to 2022
Abstract Introduction: Despite global decreases in overall cancer incidence, the incidence of multiple myeloma (MM) continues to increase at...
Novel allogeneic BCMA CAR-expressing iNKT cells with PD1 deletion demonstrate superior tumor control in a multiple myeloma preclinical model
Abstract Background: Two BCMA-directed CAR-T cell products, Idecabtagene vicleucel (ide-cel) and Ciltacabtagene autoleucel (cilta-cel), have...
Safety, tolerability and efficacy of mesutoclax to treat patients with myeloid malignancies
Abstract Background :Venetoclax has been approved for the treatment of newly diagnosed acute myeloid leukemia (AML) in elderly or unfit patie...
Steroid-toxicity in newly diagnosed patients with multiple myeloma treated with a limited dexamethasone regimen; Results from the nmsg rest study
Abstract Introduction: For decades corticosteroids (steroids) have been essential in treating patients with multiple myeloma (MM). However,...
Rethinking neutropenia thresholds: Ethnicity-specific distributions and mortality associations in the United States adult population using national health and nutrition examination survey 2017–2018
Abstract Introduction Absolute neutrophil count (ANC) is widely used to define neutropenia, with an ANC <1500/μL serving as a univers...
High-dose cryopreserved bone marrow from deceased donors may reduce relapse in HLA-mismatched allogeneic transplantation: Day 180 post-transplant HOPE update
Abstract Allogeneic hematopoietic cell transplantation (alloHCT) is a potentially curative treatment for many hematologic malignancies. Hist...