Blood
Articles in this Issue
Real world experience of patient outcomes in a dedicated clonal hematopoiesis hematology clinic
Abstract Introduction: Clonal hematopoiesis (CH) is a pre-malignant entity associated with increased risk of myeloid neoplasm (MN), cardiovas...
Imatinib in mast cell activation syndrome: A retrospective pilot study
Abstract Introduction. Idiopathic mast cell activation syndrome (MCAS) is an immunologic disorder characterized by inappropriate activation...
CTD402, allogeneic anti-CD7 CAR t-cell, in relapsed or refractory (R/R) t-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) - report of clinical outcomes at the recommended phase 2 dose (RP2D)
Abstract Background R/R T-ALL/LBL poses significant therapeutic challenge due to paucity, and limited efficacy, of treatments. CTD402, is a...
Single-cell sequencing reveals the impact of low-dose vs standard-dose chemotherapy and infection on lymphocytes in pediatric AML
Abstract Background Lymphocytes play a critical role in immune responses, and changes in their quantity and function are closely related to...
Absence of lymphocytosis after starting treatment with cbtki is a rare phenomenon except for CD49d positive CLL mainly expressed in trisomy 12.
Abstract Introduction: Covalent Bruton tyrosine kinase inhibitors (cBTKi) have revolutionized the treatment of Chronic Lymphocytic Leukemia...
Light-chain MGUS defined as per the revised definition of the istopmm study: Experience from the university of calgary MGUS clinic
Abstract Background: Monoclonal Gammopathy of Undetermined significance (MGUS), the precursor of multiple myeloma (MM) and other lymphoproli...
Impact of noncoding tandem repeat sequence on TPMT function and thiopurine metabolism in children with ALL
Abstract Background: Prolonged exposure to thiopurine drugs is a crucial component of curative therapy for acute lymphob...
Trends in multiple myeloma mortality among patients with anemia in the United States, 1999–2024: A CDC wonder database analysis
Abstract INTRODUCTION: Anemia is a frequent and clinically significant complication in patients with multiple myeloma (MM), often reflecting...
Mutations in IDH1 and IDH2 portend a poor prognosis in adult patients with acute lymphoblastic leukemia
Abstract Background While prior studies suggest that IDH1 and IDH2 mutations confer a poor prognosis in acute lymphoblastic leukemia (ALL),...
Evolution of expert and healthcare professional treatment recommendations in the management of Mantle Cell Lymphoma
Abstract Background: Recent approvals and clinical trials have established covalent BTK inhibitors (BTKis), including ibrutinib, acalabrutin...
UBTF tandem duplications generate a nuclear export signal motif that drives an XPO1 dependency in leukemia
Abstract UBTF tandem duplications (UBTF-TDs) define a high-risk molecular subtype of acute myeloid leukemia (AML) and myelodysplastic syndro...
LIME: A first-in-class of live bacterial immune engagers for cancer immunotherapy
Abstract Background: While current immune cell engagers have shown therapeutic promise, systemic exposure can lead to cytokine release syndr...
Aberrant activation of clpp exerts multifaceted anti-AML activity beyond tumor cells
Abstract Background and Objectives The progression of acute myeloid leukemia (AML) relies not only on tumor cells but also involves leukemia...
PD-1/CD20 dual-target therapy in unfit diffuse large B-cell lymphoma: A real-world pilot study
Abstract Background Unfit patients with diffuse large B-cell lymphoma (DLBCL) often exhibit poor tolerance to intensive chemotherapy, necess...
Early interventions to reduce sickle cell childhood mortality in Africa (Global Burden of Disease Impact)
Abstract Background Sickle cell disease (SCD) is a major contributor to under-five mortality in sub-Saharan Africa, where ~75% of the world'...
NEAT1-triggered collateral activity of CRISPR/Cas13 exhibits antileukemic activity
Abstract Numerous RNAs are highly expressed in specific types of cancers, yet many lack functional significance. Similarly, most mutations o...
Higher ability of the bone marrow chimerism rate compared with the sorted t-cell chimerism rate to predict AML relapse
Abstract Introduction： Allogeneic hematopoietic stem cell transplantation is a critical treatment for acute myeloid leukemia (AML) and acut...
Development of an Adapted Resource and Implementation Application (ARIA) global guideline for the treatment of children with acute lymphoblastic leukemia
Abstract While cure rates for acute lymphoblastic leukemia (ALL) have improved significantly over the last few decades, there remain major d...
Characterization of cerebrospinal fluid pleocytosis and cell subsets during blinatumomab therapy for pediatric B-ALL: A real-life study from China
Abstract Introduction: The central nervous system (CNS) is recognized as a key “sanctuary site” in B-cell acute lymphoblastic leukemia (B-AL...
Overall survival in patients with acute lymphoblastic leukemia in the aya population, treated with modified pediatric chemotherapeutic schemes, a real-life study
Abstract Introduction Chemotherapy treatments in the pediatric population have shown high survival rates (80% to 90%) in...
Treatment-specific prognostic performance of ELN 2022, ELN 2024, and beat AML 2024: A real-world AML validation study
Abstract Introduction The European Leukemia Net (ELN) 2022 stratified acute myeloid leukemia (AML) patients (pts) treated with intensive che...
Effectiveness and safety of bispecific antibodies in relapsed/refractory diffuse large B-cell lymphoma (DLBCL): A systematic review and meta-analysis
Abstract Background: Relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL) remains a clinical challenge with limited treatment op...
Efficacy and safety of pegylated interferon alfa-2b combined with tyrosine kinase inhibitors in chronic Phase chronic myeloid leukemia patients with TKI resistance or intolerance
Abstract Background In the TKI era, long-term survival of chronic phase chronic myeloid leukemia (CP-CML) patients approaches that of the ge...
Distinct distributions of lymphocyte subsets in myelodysplastic syndrome correlate with risk stratification
Abstract Introduction Myelodysplastic syndromes (MDS) are a group of heterogeneous clonal disorders affecting hematopoietic stem cells. The...
Cyclophosphamide versus methotrexate for treating large granular lymphocyte leukemia: Real-world data insights
Abstract Background: Large granular lymphocyte leukemia (LGLL) is a rare clonal disease marked by the excessive growth of large granular lym...