Blood
Articles in this Issue
Daratumumab monotherapy versus active monitoring in patients with high-risk smoldering multiple myeloma: Aquila outcomes based on mayo 2018/IMWG 2020 risk stratification, IMWG 2020 plus cytogenetic criteria, and age
Abstract Introduction : Current standard of care for smoldering multiple myeloma (SMM), an asymptomatic precursor of mul...
First-in-class small molecule calmodulin pathway modulators attenuate excess p53 activity and correct erythropoietic defects in models of diamond-blackfan anemia (DBA)
Abstract Diamond-Blackfan Anemia (DBA) is a rare congenital bone marrow failure disorder with patients manifesting macrocytic anemia in infa...
Novel microfluidic rheology assay for in vitro-differentiated red blood cells: Enhancing quality control and therapeutic evaluation in sickle cell disease gene therapies
Abstract Introduction Gene therapies for sickle cell disease (SCD) edit hematopoietic stem cells (HSCs) to generate healthy red blood cells...
RAG1/2 expression in follicular lymphoma marks candidate precursor cells of high-grade B cell lymphoma with MYC and BCL2 rearrangements
Abstract High-grade B cell lymphoma with MYC and BCL2 rearrangements (HGBCL-DH-BCL2) represent an infrequent, life-threatening clinical enti...
Deep neutrophil phenotyping uncovers complement-mediated neutrophil dysregulation in sickle cell disease
Abstract Introduction Sickle cell disease (SCD) impacts millions globally. Acute chest syndrome (ACS) is the leading cau...
Deciphering the mechanistic role of mixed lineage leukemia partial tandem duplications (MLLPTD) in MDS and AML
Abstract The mixed lineage leukemia (MLL) methyltransferase gene is a member of the trithorax group family of factors and plays a significan...
Diffuse fractures in a neonate with homozygous UROS C73R congenital erythropoietic porphyria: An unreported phenotype
Abstract Introduction: Congenital erythropoietic porphyria (CEP) is an ultra-rare autosomal recessive disorder, usually...
Refining diffuse large B-cell lymphoma subtyping using lymphly, an evidence-based classifier
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is clinically and genetically heterogeneous, with 20–40% of patients relapsing af...
Pregnancy outcomes in women conceiving after HSCT for childhood or adolescent leukemia
Abstract Background: Myeloablative conditioning delivered before childhood or adolescent hematopoietic stem-cell transplantation (HSCT) redu...
The profile of clinical and laboratory features of Chinese vexas syndrome patients with hematological abnormalities: A single-center case series
Abstract VEXAS syndrome is a recently characterized hemato-inflammatory disorder caused by somatic mutations in the X-linked UBA1 gene in he...
Clonal hematopoiesis and lung adenocarcinoma pathogenesis
Abstract Background and Objective: Clonal hematopoiesis (CH) arises from expansion of hematopoietic stem cells bearing somatic mutations, an...
Targeted capture sequencing identifies driver mutations and enables prognostic modeling in multiple myeloma
Abstract Introduction Multiple myeloma (MM) remains incurable with pronounced prognostic heterogeneity, driven by extensive genomic complexi...
Dermatologic adverse effects with elranatamab mimicking talquetamab
Abstract Bispecific antibodies (BsAbs) have become an important therapeutic option for patients with relapsed/refractory multiple myeloma (R...
PSMD3 orchestrates metabolic reprogramming and immunogenic cell death in multiple myeloma
Abstract Background and Rationale Multiple myeloma (MM) is a cancer of the plasma cells characterized by excessive production of immunoglobul...
Clinical features and outcomes of acquired versus baseline TP53 mutations in myeloid neoplasms: A single-center retrospective analysis
Abstract Background: TP53 encodes a tumor suppressor protein that plays a critical role in regulating cell division and apoptosis. While mut...
CRISPR-Cas9 screen-driven identification of metabolic vulnerabilities reveals synthetic lethality via synergistic targeting of mitochondrial energy pathways and lactate export in oxphos-dependent T-ALL
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignancy driven by uncontrolled proliferation of i...
Real-world (RW) outcomes of newly diagnosed multiple myeloma (NDMM) patients (pts) treated with front-line daratumumab (dara), bortezomib (bor), lenalidomide (len) and dexamethasone (dex) (DVRd)
Abstract Background: The phase II and III GRIFFIN and PERSEUS studies evaluated DVRd vs. VRd in NDMM pts that were transplant eligible (TE)....
Interest, barriers, and motivators for pursuing hematology electives among fourth-year Caribbean medical students: A cross-sectional survey
Abstract Background: The evolving complexity of hematology necessitates early engagement of medical students to sustain a skilled and divers...
A comprehensive analysis of PCR for BCR::ABL1 and next-generation sequencing (NGS)-based measurable residual disease (MRD) with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL): Prevalence, association with transcript type, and clinical outcomes
Abstract Background: NGS for IG/TCR rearrangements is a highly sensitive tool for detecting MRD in ALL. NGS MRD negativity with low-level de...
High dose iron infusions in pregnant women are effective, safe, and well-tolerated
Abstract Background: Iron infusions in pregnant women who have iron deficiency anemia (IDA) have been shown to be effective, safe, and well-...
Pola-R-CHP in previously untreated diffuse large B-cell lymphoma: Real-world data in Russia
Abstract Introduction: Polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP) was approved...
A decisional intervention for older patients with Acute Myeloid Leukemia and their oncologist: A pilot randomized controlled trial (RCT)
Abstract Introduction: Treatment shared decision-making (SDM) is challenging for older adults with newly diagnosed acute myeloid leukemia (A...
Chidamide reprograms AML-associated macrophages via HDAC3 inhibition to boost CD8+ T cell immunity
Abstract Introduction: Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by frequent relapse and treatment...
Digital cognitive behavioral therapy vs. education intervention in population with sickle cell disease experiencing pain: A systematic review
Abstract Introduction: Chronic pain in sickle cell disease (SCD) patients impairs daily functioning and quality of life, despite advances in...
Inhibition of platelet kinase signaling and scaffolding activities with small molecule proteolysis-targeting chimeras (PROTACs)
Abstract Tyrosine kinase inhibitors (TKIs) play an expanding role in treating cancers and other diseases, including thromboinflammatory and...