Blood
Articles in this Issue
National analysis of real-world racial and ethnic disparities in mortality, complications, and healthcare costs among adults hospitalized with newly diagnosed Acute Myeloid Leukemia
Abstract Background Impact Statement: This first nationally representative analysis focused exclusively on newly diagnosed AML demonstrates...
USP28 promotes multiple myeloma progression by regulating NF-κB signaling through KIF20B
Abstract Myeloma, as the second most common hematologic malignancy in the world, has seen significant improvements in prognosis due to the e...
Genomic heterogeneity and prognostic implications in CAR-t-treated relapsed/refractory primary CNS lymphoma
Abstract Background: In recent years, CAR-T therapy has gradually emerged as a treatment option for relapsed/refractory primary central nerv...
A VPAC1/2-targeted antagonist, preferentially binds to activated T cells and enhances T cell activation
Abstract Introduction: Vasoactive intestinal peptide (VIP) is an immunosuppressive neuropeptide signaling through VPAC1/VPAC2 receptors on T...
Health care resource utilization in patients with multiple myeloma receiving bispecific antibody therapy with teclistamab: A Medicare claims database analysis in the US
Abstract Background: Four bispecific antibodies (bsAbs), teclistamab, elranatamab, talquetamab, and linvoseltamab have b...
Siltuximab-mediated suppression of CRP is associated with clinical response in idiopathic multicentric castleman disease
Abstract Introduction Idiopathic multicentric Castleman disease (iMCD) is a rare and serious disorder involving multicen...
Data update of a single-arm, Phase II Study of orelabrutinib with/without Rituximab in patients with chronic lymphocytic leukemia/small Lymphocytic Lymphoma after BTK inhibitor therapy
Abstract Background: Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a common hematologic malignancy, and Bruton's tyro...
Long-term outcome and risk factors for relapse after allogeneic hematopoietic stem cell transplantation in myelofibrosis: Results from a large multicenter cohort
Abstract Background Allogeneic hematopoietic stem cell transplantation (alloHCT) is increasingly performed in Myelofibro...
Outcomes after bone marrow versus peripheral blood mismatched unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis
Abstract BACKGROUND: Posttransplant cyclophosphamide (PTCy) is increasingly utilized as graft-versus-host disease (GVHD) prophylaxis in allo...
Safety of prothrombin complex concentrate for emergency surgery according to the oral factor xa inhibitor level
Abstract Background: The incidence of thrombotic events after use of 4-factor prothrombin complex concentrate (4F-PCC) for oral factor Xa in...
Efficacy and safety of ruxolitinib-based combination therapy in the patients with myelofibrosis (MF): A systematic review and meta-analysis
Abstract ABSTRACT Background: Myelofibrosis (MF) is a chronic myeloproliferative neoplasm characterized by splenomegaly, anemia, bone marrow...
Thrombocytopenia at diagnosis adversely affects overall and leukemia-free survival in lower-risk MDS patients: A retrospective study from the FISiM registry
Abstract Background Thrombocytopenia is a frequent hematologic abnormality in patients with myelodysplastic syndromes (MDS), occurring in ap...
Healthcare transition readiness for sickle cell disease: A high- and low- income comparative analysis
Abstract Background: Sickle cell disease (SCD) is the most common inherited hemoglobinopathy globally, with the greatest burden in low- and...
Impact of cytoreduction on thrombotic and bleeding outcomes in patients with myeloproliferative neoplasms and atrial fibrillation
Abstract Background Myeloproliferative neoplasms (MPNs), such as polycythemia vera (PV) and essential thrombocythemia (ET) have an increased...
Cytokine receptor armored CAR-T cells enable robust T cell expansion and function in the absence of lymphodepletion
Abstract Chimeric antigen receptor (CAR) T cell therapy is emerging as a promising approach for oncology and autoimmune diseases. However, i...
First-in-human trial of siltuximab in combination with standard induction chemotherapy in patients with acute myeloid leukemia: The Phase 1 siltuxilam study.
Abstract Background: Numerous studies have pointed out the pathological role of deregulated expression of Interleukin-6 (IL-6) in cancers. I...
Monocytosis as prognostic factor for chronic graft versus host disease
Abstract INTRODUCTION Chronic graft-versus-host disease (cGvHD) is the main cause of long-term morbidity and mortality a...
Lenalidomide (LEN) and anti-CD38 monoclonal antibodies (mAbs) utilization in patients with newly diagnosed and relapsed/refractory multiple myeloma (MM) in Germany: Real-world insights on epidemiology and clinical outcomes
Abstract Introduction: LEN has long been a foundational therapy in MM. Since the European approval of daratumumab and isatuximab, these anti...
Does stringent cytoreduction improve survival in myeloproliferative chronic myelomonocytic leukemia? a correlative study on the dacota trial.
Abstract Background. Myeloproliferation at diagnosis is an adverse prognostic factor in CMML. Cytoreduction with hydroxyurea (HY) is conside...
Impact of obesity on outcomes of CAR T-cell therapy for hematologic malignancies: A real-world propensity-matched analysis
Abstract Background: Chimeric antigen receptor (CAR) T-cell therapy is a highly effective treatment for relapsed/refractory (R/R) hematologi...
Ornithine decarboxylase deficiency in donor T cells preserves strong GVL activity while attenuating acute and preventing steroid-resistant gut GVHD in a recipient tissue PD-L1-dependent manner
Abstract Graft-versus-leukemia/lymphoma (GVL) activity and graft-versus-host disease (GVHD) are usually mediated by the same alloreactive T...
Early multi-immune modulation with rilzabrutinib in patients with primary ITP after first-line treatment failure: A phase 3b study (LUNA 4)
Abstract Background: Immune thrombocytopenia (ITP) is driven by complex immune dysregulation involving both autoimmunity and inflammation, l...
An engineered AAVrh10 vector containing an optimized factor IX transgene improves therapeutic response during hemophilia b gene therapy
Abstract Background: Gene therapy using Adeno-associated virus (AAV) vectors has emerged as a promising alternative to frequent coagulation...
FLT3L-based conjugate targets chemoresistant leukemia stem cells via cell cycle re-entry in Acute Myeloid Leukemia
Abstract Acute myeloid leukemia (AML) is a genetically heterogeneous hematopoietic malignancy with poor prognosis. Standard cytotoxic chemot...
High prevalence of clonal hematopoiesis in fanconi anemia revealed by whole exome sequencing
Abstract Fanconi anemia (FA) is an inherited bone marrow failure syndrome (IBMFS) characterized by hypersensitivity to DNA damage and a mark...