Blood
Articles in this Issue
Development and validation of a weighted cytokine scoring system for immune status Assessment Following CD19 CAR-T Therapy
Abstract Background and Aims This study developed and validated a novel immune status evaluation system utilizing multiplex cytokine profili...
Deep learning-based histopathological subtyping of peripheral T-cell lymphoma (PTCL) on H&E-stained whole slide images
Abstract Introduction Peripheral T-cell lymphomas (PTCL) are rare and highly heterogenous malignancies. The diagnosis ca...
Development of a novel LRP1 antibody that identifies upregulation of membrane LRP1 on activated and chimeric antigen receptor T cells
Abstract Low-density lipoprotein receptor-related protein 1 (LRP1) is a member of the LDL receptor family which plays a variety of different...
Space associated stem cell hallmarks of aging (SASHA) in astronauts
Abstract Previous reports revealed immune dysfunction, chromosomal abnormalities, cytokine deregulation, and telomere length dynamics follow...
Ibrutinib in the treatment of allogeneic stem cell transplant-related pure red cell aplasia: A single center experience
Abstract Background: Allogeneic stem cell transplantation (alloSCT) is a potentially curative treatment for several hematologic disorders, a...
Predicting genetic alterations in Acute Myeloid Leukemia through AI-based analysis of bone marrow morphology
Abstract Acute myeloid leukemia (AML) is characterized by significant genetic heterogeneity, with diverse cytogenetic and molecular alterati...
Central nervous system relapse is uncommon after chimeric antigen receptor T-cell therapy for relapsed/refractory large B-cell lymphoma
Abstract Introduction: Chimeric antigen receptor (CAR) T-cell therapy has significantly improved the prognosis of patien...
Invariant patterns of global mutational signatures allow new fundamental insights in etiopathogenesis of bone marrow failure including aplastic anemia and myelodysplasia
Abstract WGS data enables the definition of individual somatic mutational signatures (MS) through mathematical algorithms by identifying dis...
Iron deficiency at neonatal intensive care unit discharge in very preterm infants
Abstract Introduction: ID is the most common micronutrient deficiency worldwide. Preterm infants are especially vulnerable to ID due to low...
Redefining eIF4E's function in Acute Myeloid Leukemia: Implications for engraftment and survival
Abstract The crosstalk between acute myeloid leukemia (AML) cells and the bone marrow niche is crucial for disease progression. Modeling the...
High morbidity in adults with non-transfusion-dependent thalassemia referred to u.S. specialty centers
Abstract Introduction Non-transfusion-dependent thalassemia (NTDT) is a clinically significant form of thalassemia associated with progressi...
Revumenib in combination with intensive induction and consolidation for newly diagnosed patients with NPM1-mutated or KMT2A-rearranged Acute Myeloid Leukemia: Preliminary results from the Phase 1b etctn 10596 study
Abstract Introduction: Revumenib is a first-in-class FDA-approved menin inhibitor that has shown efficacy in patients (pts) with relapsed/re...
The need for a subsequent HCT is a late & continuous risk and with significant impact in overall survival in haemoaglobinopathies: Real-world data from 2000–2022. an analysis of the european society for blood and marrow transplantation (EBMT) hemoglobinopathy working party.
Abstract INTRODUCTION: Allogeneic hematopoietic cell transplantation (HCT) is the best established curative option for sickle cell disease (...
A compelling case for central pathology review of multiparameter flow cytometry measurable residual disease results in Acute Myeloid Leukemia (AML) clinical trials: Data from the PALG-AML1/2016 multicenter randomized study
Abstract BACKGROUND: Measurable residual disease (MRD) is increasingly recognized as a critical prognostic factor in AML for guiding therape...
Echocardiographic findings over time in sickle cell disease patients: A single-center study
Abstract Background Patients with sickle cell disease (SCD) are at risk for cardiovascular sequelae, most notably pulmonary hypertension and...
Signaling role of viral protein motif and its application in CAR T cell therapy
Abstract CD19-targeted Chimeric Antigen Receptor (CAR) T cell therapy is a leading treatment for B-cell malignancies, achieving complete rem...
Treatment patterns and outcomes in patients with myelofibrosis treated with pacritinib following a switch from ruxolitinib: The my-PAC study
Abstract Background: Ruxolitinib (RUX) is a JAK1/2 inhibitor known to induce myelosuppression and is often used at suboptimal doses in patie...
Total marrow and lymphoid irradiation (TMLI) with fludarabine-melphalan (FM) conditioning for matched donor hematopoietic cell transplant (HCT) in older patients with Relapsed/Refractory (R/R) disease
Abstract Older adults with R/R acute leukemia or MDS have dismal treatment outcomes. TMLI is a targeted radiotherapy platform that enables r...
Dosing variability of tyrosine kinase inhibitors in chronic myeloid leukemia
Abstract Introduction Tyrosine kinase inhibitors (TKIs) have been the standard therapy for chronic myeloid leukemia (CML) since 2001. The cu...
Prescribing patterns in MDS/MPN syndromes
Abstract Introduction: Myelodysplastic Syndrome (MDS)-Myeloproliferative Neoplasms (MPN) overlap syndromes, such as Chro...
Single-cell transcriptomic and clonotypic characterization of Waldenström macroglobulinemia reveals intra-patient monoclonal diversity with distinct differentiation states
Abstract Background: Waldenström macroglobulinemia (WM) is a rare, indolent B-cell lymphoma characterized by bone marrow (BM) infiltration o...
BuCy combined with cladribine and medium-dose cytarabine as an intensified conditioning regimen for allogeneic hematopoietic stem cell transplantation in T-ALL/lbl patients
Abstract Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been regarded as the most effective curative therapy...
Phase I study of the histone deacetylase inhibitor panobinostat in sickle cell disease
Abstract Introduction: Reactivation of HbF in adult life is a proven effective therapy for β-hemoglobinopathies. Hydroxyurea (HU) is the onl...
Beyond mutations: RNA editing deaminase activation as a dynamic marker to track stem cell fitness and MPN progression
Abstract Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell–derived disorders that can progress to acute myeloid leukemi...
Proliferation of mature plasmacytoid dendritic cells in RUNX1-mutated Acute Myeloid Leukemia
Abstract Introduction: Clonal expansion of mature plasmacytoid dendritic cells (pDCs), traditionally linked to chronic m...