Blood
Articles in this Issue
Engineering Quiescent Viral Entry Pathways for in Vivo CAR-T Generation via Binder-Fusogen Combinatorics
Abstract Background: In vivo delivery of CAR constructs via lentiviral vectors is hindered by a critical limitation: conventional viral enve...
Six versus eight doses of rituximab in combination with six cycles of CHOP chemotherapy in patients with previously untreated diffuse large b-cell lymphoma
Abstract BACKGROUND Six cycles of R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) are the standard first-...
Results of the promise study from ~30,000 individuals screened for monoclonal gammopathies
Abstract Background Monoclonal gammopathy (MG) of undetermined significance (MGUS) affects 3–5% of individuals aged 50 and older, as reporte...
A retrospective Study of pola-R-CHP regimen in treatment-naive patients with diffuse large B-cell lymphoma from northeast China
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is a clinically and molecularly heterogeneous subtype of non-Hodgkin lymphoma, ac...
Impact of aspirin use on clinical outcomes in antiphospholipid syndrome patients with arterial thrombosis: A real-world cohort study
Abstract Background: Antiphospholipid syndrome (APS) is a major cause of arterial thrombosis and recurrent vascular events, often requiring...
Real-world patterns of secondary malignancies and relapse following CAR T-cell therapy: A faers pharmacovigilance analysis
Abstract Background: Chimeric antigen receptor (CAR) T-cell therapies have transformed the therapeutic landscape for relapsed or refractory...
Elimination of alloantibody responses using chimeric HLA-II antibody receptor T cells
Abstract Introduction Anti-HLA antibodies (alloantibodies) pose challenges in the setting of organ or bone marrow transplantation. The prese...
Temporal trends and geographic variation in mortality from hypertensive diseases with coexisting aplastic and other anemias in the United States (1999–2023): A CDC wonder analysis
Abstract Introduction: Hypertensive disease (HD) refers to a constellation of changes in heart resulting from chronic el...
CDCP1+ mesenchymal stem cells preferentially inhibit acute graft-versus-host disease(aGVHD)
Abstract Object The main complication after hematopoietic stem cells is acute graft-versus-host disease(aGVHD), which affects the success of...
Risk factors for CRS and NT with bispecific antibodies: Data from the American bispecifics and CART (ABC) consortium
Abstract Background: Bispecific antibodies (BsAbs) have changed the treatment paradigm in aggressive B-cell lymphomas, but these agents carr...
Thrombotic risk with thrombopoietin receptor agonists in immune thrombocytopenia: Real-world evidence from a multicenter Japanese study.
Abstract Background: Thrombopoietin receptor agonists (TPO-RAs), which are widely used as second-line or later treatments for immune thrombo...
Real world outcome of nodal T cell non-Hodgkin lymphoma from hematology cancer consortium registry in India
Abstract Introduction Here we present the real-world outcome of nodal T-NHL data from a prospectively maintained lymphoma registry in India...
Risk of serious bleeding with concomitant use of apixaban or rivaroxaban with amiodarone compared to flecainide or sotalol in patients with atrial fibrillation
Abstract BACKGROUND Direct oral anticoagulants (DOACs), including apixaban and rivaroxaban, are widely used for stroke prevention in patients...
Clinical characteristics and prognosis of therapy-related hematological neoplasms: A single-center retrospective study
Abstract Objective: With expanding treatment modalities for solid and hematologic malignancies leading to improved patient survival, the inc...
Pirtobrutinib in Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL): Final update from the Phase 1/2 BRUIN study
Abstract Background: Despite the efficacy of covalent Bruton tyrosine kinase inhibitors (cBTKi) in R/R MCL, patients (pt...
Complex cytogenetics in myeloid malignancies: A deconstruction analysis redefining complex karyotypes
Abstract Background: In myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), a complex karyotype (CK) is defined as ³3 unrelate...
Platelet mTOR is a regulator of sterile immunothrombosis
Abstract Background: Immunothrombosis entails a tight interplay between thrombotic and inflammatory pathways and plays a pathological role i...
Rapid immune reconstitution in patients with transfusion-dependent thalassemia following betibeglogene autotemcel: A real-world experience
Abstract Introduction: Gene therapies for transfusion-dependent thalassemia (TDT) such as betibeglogene autotemcel (beti-cel) alleviate tran...
Unmasking PNH: Epidemiological and clinical insights from Qatar
Abstract background Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired clonal stem cell disorder caused by somatic mutations in t...
Disparate post-relapse survival outcomes by race/ethnicity for children with B-cell acute lymphoblastic leukemia: An analysis from the recall-1 study
Abstract Introduction Pronounced disparities in pediatric B-lymphoblastic leukemia (B-ALL) outcomes by race and ethnicity persist in the con...
Analysis of seasonal variation of sickle cell disease with crisis and associated complication in the United States from 2011 to 2019.
Abstract Introduction: While the clinical burden of sickle cell disease (SCD) is well recognized, observations suggests that environmental f...
Real-world incidence and management of non-icans neurologic events following ciltacabtagene autoleucel in multiple myeloma
Abstract Introduction: Ciltacabtagene autoleucel (cilta-cel) is an established effective treatment strategy for relapsed/refractory multiple...
Disease presentation and immunophenotype characteristics in 257 patients with blastic plasmacytoid dendritic cell neoplasm: A pethema/PALG study
Abstract Background Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy characterized by a...
Comparison of real-world survival outcomes and time toxicity of CAR T-cell versus bispecific antibody therapies in relapsed/refractory follicular lymphoma: A multicenter cohort from 15 US academic institutions
Abstract Background Chimeric antigen receptor T-cell (CAR-T) and bispecific antibody (BsAb) therapies are both effective...
Development of NOG-W41-based humanized mouse model for studying In Vivo human hematopoiesis
Abstract Humanized mouse models engrafted with human CD34⁺ hematopoietic stem cells (HSCs) are essential tools for studying human hematopoie...