Blood
Articles in this Issue
LDHAL6B promotes lactate-mediated histone H4K8 lactylation and enhances malignant cellular behaviors in multiple myeloma
Abstract Background Histone lactylation is a recently identified epigenetic modification derived from intracellular lactate, a key product o...
Golcadomide (GOLCA), a potential, first-in-class, oral CELMoD™ agent, plus R-CHOP in patients (Pts) with previously untreated aggressive B-cell lymphoma (a-BCL): 24-month efficacy Results
Abstract Introduction Nearly 60% of pts with diffuse large B-cell lymphoma (DLBCL) are cured with first-line chemoimmunotherapy; ~40% will r...
The impact of marginalization on outcomes in patients with Hodgkin lymphoma
Abstract Background Hodgkin lymphoma (HL) has become one of the most curable hematologic malignancies with survival rates exceeding 85%. Des...
CSF1R-CSF1 axis blockade with axatilimab effectively targets leukemia stem cells and monocytes in AML resistant to BH3 mimetics
Abstract Background: The BCL2 inhibitor venetoclax (VEN), in combination with hypomethylating agents, is highly effective in inducing remissi...
Association between circadian rhythm disruption and hematopoietic function in patients with hematologic malignancies: A cross-sectional study
Abstract Objective: Circadian rhythm disruption has been implicated in the progression of hematologic malignancies, yet its physiological im...
Dapagliflozin for treatment of sickle cell nephropathy: A multi-centre experience
Abstract Background Chronic kidney disease (CKD) is a common complication in sickle cell disease and current guidelines...
This is a title in sentence case:synnotch CD123 and CLL1 CAR-T can specifically target AML to avoid the off-target effects
Abstract Objective Chimeric antigen receptor T-cell (CAR-T) therapy targeting CLL1 has emerged as a promising immunotherapeutic approach for...
Health state utility values in congenital thrombotic thrombocytopenic purpura (cTTP): A vignette-based valuation Study in the UK general population
Abstract Introduction The aim of this UK study was to estimate health-related quality of life (HRQoL) in patients with c...
Temporal trends in cancer-associated venous thromboembolism mortality: A nationwide analysis (1999–2020)
Abstract Background: Venous thromboembolism (VTE), including the dreadful pulmonary embolism (PE), is a well-known complication of cancer. I...
Allergin-1 marks leukemic stem cells and enables immune evasion in AML: A target for therapeutic antibody development
Abstract Acute myeloid leukemia (AML) often achieves remission after therapy; however, relapse – driven by chemotherapy-resistant leukemic s...
Granulocyte transfusion improves survival and clinical recovery in pediatric febrile neutropenia: A 15-year real-world cohort study from Thailand
Abstract Background: Febrile neutropenia (FN) remains a leading cause of morbidity and mortality in pediatric patients with high-risk hemato...
Multimodal evaluation of brain injury and cerebral iron deposition in thalassemia patients: A combined human-imaging and murine model study
Abstract Introduction: Chronic anemia and iron overload in thalassemia (TM) may contribute to neurological injury, though this remains under...
A novel, structured peer support intervention (STEPP) for patients undergoing hematopoietic stem cell transplantation: A pilot randomized clinical trial
Abstract Background: Peer support has been associated with improved patient-reported outcomes (PROs), including reduced psychological distre...
Sequential tracking of FLT3-ITD architecture reveals length-dependant impact on clonal clearance and clinical outcome
Abstract Introduction FLT3-ITD mutations are associated with adverse outcomes in acute myeloid leukemia (AML). However,...
Genetic landscape of Hemophilia A in Korea: Insights from precision diagnosis in Hemophilia A
Abstract Background : Hemophilia A(HA) is an X-linked recessive coagulation disorder associated with factor VIII (F8) gene mutation. F8 gene...
Fractionated gemtuzumab ozogamicin (GO) with high-dose cytarabine (HiDAC) based induction chemotherapy is safe and highly effective for newly diagnosed favorable risk AML.
Abstract Background: Several randomized trials establishedbenefit of GO when added to intensive chemotherapy for newly diagnosed AML, particu...
The role of red blood cell lifespan in evaluating the condition of patients with paroxysmal nocturnal hemoglobinuria treated with complement inhibitors
Abstract Introduction：Paroxysmal nocturnal hemoglobinuria (PNH) is an extremely rare acquired clonal disorder of hematopoietic stem cells....
Acrobat interim results: Alloheme surveillance enables early detection of relapse in post-HCT AML and MDS patients
Abstract Introduction: Relapse is the leading cause of mortality after allogeneic hematopoietic cell transplantation (HCT) for acute myeloid...
Clonotypic peptide mass spectrometry to monitor m-protein reduction in patients with relapsed/refractory multiple myeloma from ikema Study
Abstract Background: Relapsed/refractory multiple myeloma (RRMM) remains difficult to monitor with bone marrow aspiration (BMA)–based minima...
Beyond FISH: CMA detects 8p-, xq+, and y- as markers of early post-transplant progression in myeloma
Abstract Background: Multiple myeloma (MM) encompasses a broad clinical spectrum from indolent to aggressive disease. Re...
Impact of concurrent antiplatelet/NSAID use on the safety and efficacy of thromboprophylaxis with apixaban in patients with cancer: A post-hoc analysis of the AVERT trial
Abstract Background: The risk of venous thromboembolism (VTE) is significantly increased in patients with cancer compared to the general pop...
Racial and socioeconomic disparities in adult acute lymphoblastic leukemia: A multicenter cohort study
Abstract Over the past two decades, advances in the treatment of B-cell Acute Lymphoblastic Leukemia (B-ALL) have led to markedly improved p...
Real-world assessment of early toxicities, treatment modifications, and outcomes with daratumumab, bortezomib, lenalidomide, and dexamethasone (D-VRd) in multiple myeloma
Abstract Background: Daratumumab combined with bortezomib, lenalidomide, and dexamethasone (D-VRd) is a widely used frontline regimen for mu...
CAR-seet 01: A pilot study for diagnosing CRS and icans using wearable consumer devices
Abstract Background: Chimeric antigen receptor T-cell (CAR-T) and bispecific antibody (BsAb) therapies represent burgeoning treatment option...
Treatment disparities in sickle cell disease among patients with asymptomatic HIV
Abstract Background: Sickle cell disease (SCD) often requires transfusion-based therapies to manage acute complications. Guideline directed...