Blood
Articles in this Issue
Predictors of early mortality in Acute Myeloid Leukemia: A population based analysis using SEER data.
Abstract Background: Acute myeloid leukemia (AML) is associated with high early mortality, especially among older adults and those with limi...
Firicabtagene autoleucel (firi-cel), a CD22-directed CAR T-cell therapy, for patients with relapsed/refractory large B-cell lymphoma: Results from the phase 2 study (FIRCE-1 Trial)
Abstract Introduction: Based on efficacy of CD22-targeted CAR T-cells in a phase I trial in adults with relapsed/refractory (r/r) large B-ce...
Applying the bedside SaO2/FiO2 ratio to adolescents with acute chest syndrome to triage ICU transfer
Abstract Introduction We previously described the relationship between the diagnostic SaO2/FiO2 ratio – the ratio of the peripheral oxygen s...
Decoding the ektacytometric landscape of hereditary spherocytosis: Insights from 204 cases
Abstract Hereditary Spherocytosis (HS) is the most common congenital hemolytic anemia in individuals, with a prevalence of about 1:2000–1:30...
Ascertaining sickle cell disease: Comparing electronic health record and genomic data in the all of us research program
Abstract Sickle cell disease (SCD) is a genetic hemoglobinopathy affecting 100,000 Americans – predominantly Black/African-Americans. The mo...
BRD4 sustains immunosuppressive erythroid precursors to compromise CAR-T cell function
Abstract Introduction: Emerging evidence suggests that the immunosuppressive tumor microenvironment is a major limiting factor impairing CAR...
Efficacy and safety of romiplostim N01 for refractory aplastic anemia: A retrospective single‑center study
Abstract Objective: To evaluate the efficacy and safety of romiplostim N01 in patients with refractory aplastic anemia (AA)....
Implementation of 2020 international guidelines in acquired hemophilia: Insights from a decade of national registry data in Spain
Abstract Background: Acquired hemophilia A (AHA) is a rare but potentially life-threatening autoimmune bleeding disorder caused by the devel...
Venetoclax in combination with hypomethylating agents are effective salvage therapy in relapse/refractory ETP-ALL and near-ETP-ALL
Abstract Introduction Limited progress has been made in the treatment of T-lymphoblastic leukaemia/lymphoma (T-ALL/LBL)...
The use of anticoagulation on paroxysmal nocturnal hemoglobinuria.
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematological disorder with an increased risk of thrombosis...
Age-related left-digit bias in selection of patients referred for autologous and allogeneic hematopoietic transplantation: An analysis of 877 patients referred to a single center
Abstract Left-Digit Bias (LDB) is a well described cognitive phenomenon that results in greater emphasis of the left-most digit of a continu...
Human bone scaffolds support clonal persistence and functional retention of MDS-derived CD34+ cells in a 3D in vitro bone marrow model
Abstract Introduction: Myelodysplastic neoplasms (MDS) are clonal hematopoietic disorders with ineffective hematopoiesis...
An IL-10-incorporated predictive model for late immune effector cell-associated hematotoxicity following CAR-T therapy in B-cell malignancies
Abstract Introduction: Immune effector cell–associated hematotoxicity (ICAHT) is a common complication of chimeric antig...
Risk of thrombotic and bleeding events in patients with MPNs - does SSRI use have an impact?
Abstract Background: Myeloproliferative neoplasms (MPNs) are associated with an elevated risk of thrombotic and hemorrha...
Oral mucosal complications in chronic granulomatous disease - a role of Nox2 oxidase in regulating oral neutrophil responses
Abstract Chronic granulomatous disease (CGD) is a devastating immunodeficiency caused by inactivating mutations in the superoxide-generating...
Enhancing graft-versus-host disease prophylaxis with modern strategies in matched-sibling or unrelated donor hematopoietic cell transplantation does not lead to higher relapse rates: A systematic review and meta-analysis of 15 randomized trials
Abstract Introduction: Effective graft-versus-host disease (GVHD) prophylaxis is a crucial part of hematopoietic cell transplantation (HCT)....
Clinical and biological impact of plasma cytokine levels in newly diagnosed chronic lymphocytic leukemia
Abstract BACKGROUND: Concentrations of specific cytokines/chemokines are consistently associated with patient prognosis in different cancer...
Improved survival with third-line CAR-T therapy vs alternative treatment in DLBCL: A propensity score–matching analysis
Abstract Introduction Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the management of relapsed/refractory diffuse large B-...
EV-mirnas predict outcomes in pediatric AML: A pilot study
Abstract Introduction: In recent years, extracellular vesicles (EVs) have gained significant interest in AML biology and prognostication. EVs...
Multitarget kinase inhibitor olverembatinib is active and synergizes with BTK inhibitor acalabrutinib in preclinical models of Mantle Cell Lymphoma
Abstract Background Mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkin lymphoma derived from pre-germinal center B cells. It is an...
Artificial intelligence-assisted multi-parameter flow cytometry gating for minimal residual disease detection in acute lymphocytic leukemia: A systematic review and meta-analysis
Abstract Background: Acute Lymphocytic Leukemia(ALL) is the most prevalent childhood cancer and a major hematologic malignancy in adults. Mi...
A phase I/II trial of azacitidine and venetoclax in previously untreated Myelodysplastic Syndromes
Abstract Background Only one-third of patients with higher-risk myelodysplastic syndromes (MDS) respond to hypomethylating agents. The overa...
Nanopore sequencing to detect BCR::ABL1 and associated genomic rearrangements in CML
Abstract Background. Approximately 98% of CML patients express e13a2 and/or e14a2 BCR::ABL1 mRNA isoforms resulting from genomic breakpoints...
Interim analysis of a non-interventional prospective descriptive study to assess the impact on Patient´s well-being of fixed-time duration (FTD) and continuous oral regimens for newly diagnosed and relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) in routine clinical practice in Spain
Abstract Chronic lymphocytic leukemia (CLL) remains in most cases an incurable disease; and treatments often aim to improve quality of life...
A phase 1 study of lucar-G39D: A novel anti-CD20/CD19 dual-CAR allogeneic gamma delta T cells in adults with relapsed / refractory B-cell non-Hodgkin lymphoma (NHL)
Abstract Introduction: Autologous CD19-targeted chimeric antigen receptor (CAR)-T cell therapies have demonstrated clinical benefit for pati...