Blood
Articles in this Issue
Fixed-dose inotuzumab ozogamicin combined with vincristine and prednisone regimen as induction therapy for newly diagnosed B-cell acute lymphocytic leukemia
Abstract Background: Adult acute B-cell lymphocytic leukemia (B-ALL) exhibits significant prognostic heterogeneity. The complete remission (...
Odyssey: A first-in-human study of the aldehyde dehydrogenase (ALDH) inhibitor abd-3001 in patients with refractory/relapsed acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS)
Abstract Background Despite therapeutic advances in acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (HR-MDS), outcomes f...
Comparative immune profiling reveals T-cell exhaustion in EBV+ monomorphic PTLD vs. immunocompetent DLBCL
Abstract Background: Post-transplant lymphoproliferative disorder (PTLD) occurs in up to 30% of high-risk solid organ transplant recipients a...
Molecular insights from ctdna dynamics: Monitoring MRD and tracking divergent progression modes and clonal evolution patterns
Abstract Background: Both baseline clinical and biological parameters, including IPI, and end-of-treatment PET (EOT-PET), which assesses tre...
Immune effector cell-associated enterocolitis (IEC-EC) across CAR-T products in myeloma and lymphoma: A real world pharmacovigilance analysis
Abstract Introduction: IEC-EC has emerged as a unique toxicity of BCMA-targeted CAR-T therapy in multiple myeloma (MM) p...
Impact of lenalidomide pre-apheresis on markers of T cell fitness and pharmacodynamic biomarkers in newly diagnosed multiple myeloma patients with suboptimal response to autologous stem cell transplantation
Abstract Introduction Autologous stem cell transplantation (ASCT) is a frontline treatment for multiple myeloma (MM), but can result in T ce...
Fedora preliminary analysis of a Phase II study evaluating the tolerability, safety and activity of fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis.
Abstract Background: In myelofibrosis (MF), JAK2 inhibitors alone are not curative. Fedratinib is a selective JAK2 inhibitor. Ropeginterfero...
Identification of biomarkers to predict disease progression via molecular analysis of patients (pts) with low-risk myelofibrosis (MF) enrolled in the MOST study
Abstract Background: The Myelofibrosis and Essential Thrombocythemia Observational Study (MOST; NCT02953704) is a prospective observational...
Delta opioid receptor (DOR) expression on myeloid-derived suppressor cells (MDSCs) represents a novel target to overcome resistance to immune checkpoint inhibitors (ICIs)
Abstract Several studies suggest an association between opioid use for cancer pain and shorter survival, with research in animals indicating...
Pure red cell aplasia associated with thymic follicular lymphoid hyperplasia: Complete remission after thymectomy without immunosuppression
Abstract Background: Pure red cell aplasia (PRCA) is a rare hematologic disorder characterized by severe anemia, reticulocytopenia, and sele...
Factors influencing outcomes in therapy-related myeloid neoplasms following allogeneic hematopoietic stem cell transplantation
Abstract Introduction: Therapy-related myeloid neoplasms (t-MN), including therapy-related myelodysplastic syndrome (t-MDS) and acute myeloi...
Thirty-day readmission in patients with brain cancer and venous thromboembolism: A nationwide analysis using the national readmissions database
Abstract Background: Venous thromboembolism (VTE) is a common and life-threatening complication in patients with brain c...
Outcomes of patients with Relapsed/Refractory aggressive B-cell lymphoma receiving bispecific antibody therapy as monotherapy or in combination with targeted therapy
Abstract Introduction Bispecific antibodies (BsAbs) have added to the treatment landscape for relapsed/refractory (R/R) large B-cell lymphom...
CXCR6-dependent ILC3 migration to the intestinal stem cell compartment promotes epithelial regeneration after conditioning-related intestinal injury
Abstract Interleukin-22 (IL-22) has been shown to promote epithelial regeneration, protect the intestinal stem cell (ISC) compartment from d...
Validation of baseline total metabolic tumor volume (TMTV) as a predictor of early progression (POD24) in follicular lymphoma: A retrospective study of 100 patients in Brazil.
Abstract Background: Follicular lymphoma (FL) is the second most prevalent non-Hodgkin lymphoma, characterized by an indolent course with re...
Deep learning-based image analysis of pretreatment FDG-PET/CT predicts CAR-T cell treatment outcome at month-12 for patients with Relapsed/Refractory large B-cell lymphomas
Abstract Introduction: We previouslyreportedthe feasibility of predicting treatment outcome of chimeric antigen receptor modified T-cell (CA...
Temporal multiomic profiling reveals intrinsic resistance mechanisms to ERK inhibition in relapsed Acute Myeloid Leukemia
Abstract Background: The RAS/MAPK signaling pathway is hyperactivated in acute myeloid leukemia (AML). RAS/MAPK signaling converges on the ex...
In-class transition from bortezomib to ixazomib-based regimens in transplant-ineligible patients with newly diagnosed multiple myeloma: A retrospective, observational, real-world study conducted in China
Abstract Background Proteasome inhibitors (PIs) are cornerstone therapeutic agents in the management of multiple myeloma...
Survival trends in systemic amyloidosis over two decades: A real-world cohort analysis
Abstract Background: Systemic amyloidosis is a rare, underdiagnosed, often fatal disorder with historically poor prognosis. Over the past tw...
Combined nutrition education and vocational training for caregivers of children with sickle cell anemia and severe malnutrition: A feasibility study
Abstract Introduction Malnutrition is a significant cause of morbidity and mortality for children living in low- and middle-income countries...
Modeling autosomal dominant erythrocytosis due HIF-2α E398K mutation reveals novel mechanism of erythropoiesis control
Abstract We report family with autosomal dominant erythrocytosis, when the proband (woman, age 67 when first studied had hemoglobin 15.8 g/d...
The role of MYD88L265P in extranodal manifestations of B-cell non-Hodgkin lymphomas
Abstract Non-Hodgkin lymphomas are a heterogeneous group of B-cell neoplasms that can present with nodal and extranodal (EN) disease. The pr...
An immune desert phenotype underlies therapy resistance in LBCL through distinct microenvironment-related miRNA profiles
Abstract Large B-cell lymphoma (LBCL) is an aggressive hematological malignancy characterized by significant clinical and genetic heterogene...
Population pharmacokinetics (popPK) and exposure-response (ER) analyses of lbl-034, a potent GPRC5D T cell engager in patients with relapsed/refractory multiple myeloma
Abstract Introduction LBL-034 is a humanized IgG1 subtype asymmetric bispecific antibody targeting GPRC5D and CD3. Its affinity-optimized an...
Clinical characteristics and treatment evaluation of T-cell lymphoblastic lymphoma in Chinese children and adolescents：a multicenter clinical study of China-net childhood lymphoma-lbl-2017
Abstract BackgroundT-cell lymphoblastic lymphoma (T-LBL) is the second most common subtype of non-Hodgkin's lymphoma (NHL) in children and a...