Blood
Articles in this Issue
Teclistamab in a large cohort of ~100 Asian patients with triple-class exposed multiple myeloma: Experience from trials and non-trial settings
Abstract Introduction: Teclistamab (tec) is the first globally approved B-cell maturation antigen (BCMA) × CD3 bispecific antibody (BsAb) wi...
Incidence burden of AML across the US and Puerto Rico: A two-decade analysis of trends and disparities (1999-2021)
Abstract BACKGROUND: Acute myeloid leukemia (AML) is one of the most aggressive forms of hematologic malignancy of adults; its incidence inc...
Loss of cell cycle regulators RB1 and CDKN2A/2B induces CLL with distinct disease kinetics in murine models and shows distinct outcomes in CLL patients
Abstract Deletion of the RB1 gene, which encodes a tumor suppressor that inhibits cell cycle progression, is found in approximately 15% of c...
BTK regulates EZH2 stability in myeloid leukemia associated with down syndrome
Abstract Children with Down syndrome (DS) have a significantly higher risk of developing acute myeloid leukemia (ML-DS), a distinct leukemia...
Long-term risk and racial disparities in second primary malignancies among diffuse large B-cell lymphoma survivors: A SEER-based analysis MP-SIR analysis (2000–2022)
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma. With more...
Efficacy and prognostic determinants of BTK inhibitors in chronic lymphocytic leukemia (CLL): A real-world single-center cohort study from China
Abstract Background CLL is the most common adult leukemia in Western countries, with a rising incidence in China. Bruton's tyrosine kinase (...
Patients with TP53-mutated AML/MDS without complex or monosomal karyotype can achieve durable survival benefits with allogeneic HCT
Abstract Introduction Whether allogeneic hematopoietic cell transplantation (HCT) is curative for acute myeloid leukemia...
Epidemiology and outcomes of rosai-dorfman-destombes disease (RDD): A ten year single-center real world experience
Abstract Introduction - Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis that typically causes painless lymphadenopat...
Redefining what “on Hydroxyurea” means
Abstract Introduction Hydroxyurea (HU) has been shown to reduce hospitalizations, pain crises, mortality, and several long-term complication...
Multi-hit TP53 mutation is an independent adverse prognostic factor in allogeneic hematopoietic stem cell transplantation for acute leukemia and myelodysplastic syndromes
Abstract Introduction TP53-mutated hematologic malignancies carry a notoriously poor prognosis, particularly in cases with multi-hit TP53 al...
Single-cell multiomic profiling of gene mutation, chromatin accessibility, and gene expression in TET2-mutant clonal hematopoiesis
Abstract Introduction Age-related clonal hematopoiesis (CH) and clonal cytopenia of undetermined significance (CCUS) represent pre-leukemic c...
Impact of G6PD Α- mutation on hemoglobin function and RBC rheology in sickle cell disease
Abstract Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is the most common erythrocyte enzymopathy. Sickle cell disease (SCD) is an aut...
Proteomic analysis identifying biomarkers in the progression from essential thrombocythemia to post-essential thrombocythemia myelofibrosis: A retrospective cohort study
Abstract Abstract: Objective：Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm that can progress...
Beyond hemostasis: Factor VIII deficiency impacts hematopoietic stem cells development in zebrafish
Abstract Introduction Hemophilia A (HA) is a monogenic bleeding disorder caused by coagulation Factor (F) VIII deficiency. Recent studies su...
Clinical manifestations, risk factors and prognosis associated with central nervous system relapse after CAR-T therapy for R/R B-cell non-Hodgkin lymphoma: A multi-center analysis
Abstract Background Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized the treatment scheme of relapsed...
Durable responses in the updated 2-year follow-up of patients from a single-center with Relapsed/Refractory peripheral T-cell lymphoma treated with golidocitinib
Abstract Background Up to 75% of peripheral T-cell lymphoma (PTCL) patients (pts) treated with frontline CHOP-based therapy have relapsed/re...
Mitoxantrone liposome combined with EAC autologous transplant conditioning for the treatment of T/NK non-Hodgkin's lymphoma
Abstract Objectives: New drug combination therapy can improve the survival rate of patients with T-cell lymphoma, but autologous hematopoiet...
Intrathecal versus intravenous methotrexate in diffuse large B-cell lymphoma: A real-world comparative outcomes study
Abstract Background: Methotrexate (MTX) is often administered either through intrathecal (IT) or intravenous (IV) routes along with R-CHOP c...
Racial disparities in clinical outcomes among patients with newly diagnosed and relapsed multiple myeloma in the United States: A 21-year comparative analysis
Abstract Background: Despite significant therapeutic advances, racial disparities persist across the continuum of care for patients with mul...
Characteristics and clinical course of younger Patients with early lesions in a contemporary cohort of 1240 patients: Low risk features and low risk of complications
Abstract Monoclonal Gammopathies of Undetermined Significance (MGUS), Smoldering Multiple Myeloma (SMM), and asymptomatic Waldenström's Macr...
Clinical outcomes of frontline ATG-based immunosuppressive therapy in older patients with aplastic anemia
Abstract Background Aplastic anemia (AA) exhibits a bimodal age distribution with incidence peaks in young adults and patients aged >6...
Evaluating the impact of stem cell transplantation in myelodysplastic syndrome using machine learning and comparative modeling
Abstract Background: Most patients with myelodysplastic syndromes (MDS) experience incomplete and short-lived responses to hypomethylating a...
Post transplantation cyclophosphamide (PTCy) combination with low-dose anti-thymocyte globulin (ATG) for gvhd prophylaxis in unmanipulated haploidentical peripheral blood stem cell transplantation without ATG in conditioning regimen
Abstract In haploidentical peripheral blood stem cell transplantation (haplo-PBSCT), the combination of anti-thymocyte globulin and post-tra...
Rising mortality attributed to agranulocytosis in myeloid leukemia among older adults in the United States : A time trend analysis
Abstract Introduction Agranulocytosis is a life-threatening complication in older adults with myeloid leukemia, yet its...
New evidence indicates that the NLRP3 inflammasome in hematopoietic stem and progenitor cells (HSPCs) maintains proper mitochondrial electron transport chain function and affects both cellular trafficking and metabolism through a gasdermin pore-mediated, alarmin-release-dependent mechanism
Abstract Background . The Nlrp3 inflammasome is an intracellular pattern recognition receptor (PRR) and a key component of innate immunity,...