Blood
Articles in this Issue
Orelabrutinib plus rituximab-based chemoimmunotherapy regimens in relapsed or refractory marginal zone lymphoma: A multicentric phase II trial
Abstract Background:Marginal zone lymphoma (MZL) is a heterogeneous B-cell malignancy that is often managed with chemoimmunotherapy (CIT) in...
Real-world outcomes and disparities of ph+ ALL in a Latino population
Abstract Introduction: Despite recent treatment advances in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL), survival...
Clinical efficacy and safety for pediatric patients with severe combined immunodeficiency disease treated with modified allo-haploidentical stem cell transplantation
Abstract Purpose: Hematopoietic stem cell transplantation (HSCT) is the curative treatment for severe combined immunodeficiency disease (SCI...
The myeloid transcription factor cebpa functions as a sequence-specific RNA binding protein via a novel n-terminal domain essential for macrophage differentiation
Abstract Introduction: CCAAT/Enhancer Binding Protein Alpha (CEBPa) is a master regulator indispensable for neutrophil development, yet its...
Enhanced tyrosine kinase inhibitor response on chronic myeloid leukemia cells upon MS4A3 mRNA delivery
Abstract Chronic myeloid leukemia (CML) is caused by BCR::ABL1, a constitutively active tyrosine kinase that induces profound expansion of t...
Exploration of optimal high-dose methotrexate-based therapy for patients with primary CNS lymphoma: A real-world study in China
Abstract Introduction: Primary CNS lymphoma (PCNSL) is a rare and highly aggressive extranodal non-Hodgkin lymphoma, with a dismal outcome in...
Emicizumab levels in patients with acquired and congenital Hemophilia A
Abstract Introduction Emicizumab is a bispecific antibody that mimics the action of FVIII and has emerged as an effectiv...
Testing for hereditary α-tryptasemia (HαT) / TPSAB1 copy number analysis by droplet digital PCR: Genotypes and phenotypes one year after TPSAB1 assay go-live
Abstract Hereditary α-tryptasemia (HαT) is an autosomal dominant genetic trait discovered in 2016 that affects 4-6% of the Western populatio...
The small activating RNA AW1-51 induces locus-specific demethylation and CEBPA protein early upregulation
Abstract Aberrant DNA methylation is a well-known feature of hematological malignancies, frequently leading to tumor suppressor genes silenc...
Platelets enhance factor VIII activity through protection from activated Protein C
Abstract Introduction Phospholipid membranes provide a catalytic surface for factor VIII (FVIII) activity in the blood c...
Hematologist based management of ocular adverse events using the VRA tool in newly-diagnosed myeloma patients, ineligible for ASCT who received belantamab mafodotin plus lenalidomide/dexamethasone: Updated results from the randomized part 2 of bela-rd Study
Abstract Introduction Belantamab mafodotin (belamaf) combinations showed superior efficacy over standard regimens in relapsed/refractory mult...
Ruxolitinib combined with dexamethasone is a promising prophylaxis method for differentiation syndrome in acute promyelocytic leukemia (APL2022)
Abstract Introduction: Acute promyelocytic leukemia (APL) has been highly cured with all-trans retinoic acid (ATRA) and...
Fibrin clot shields drive clonal selection of cancer cells: Procoagulant properties and proliferative survival of clot embedded cancer cells. a novel model of tumor microenvironment remodeling
Abstract Introduction: Cancer cells (CaCe) expressing Tissue Factor (TF) initiate thrombin generation and fibrin formation, contributing to...
Projecting non Hodgkin lymphoma mortality for young adults in the United States(2024-2040):a national population-based modeling study
Abstract Background: Non-Hodgkin lymphoma (NHL) represents a significant cancer burden in young adults. While survival rates have improved i...
Cardio-safe degrader CT-03p degrades MCL-1 and overcomes venetoclax resistance in AML.
Abstract BCL-2 family proteins are key cell death regulators. Among them, BCL-2 and MCL-1 are major anti-apoptotic proteins and play critica...
Setting the stage in KMT2A rearranged acute myelogenous leukemia in the era of menin inhibitors
Abstract Introduction: Lysine methyltransferase 2A gene rearrangements (KMT2Ar) typically occur via several translocations involving the 11q2...
A randomized phase II study of daratumumab, lenalidomide, ixazomib, and dexamethasone in transplant-ineligible or deferred patients with newly diagnosed multiple myeloma: Alliance Foundation Trial 41 (AFT-41)
Abstract Introduction The treatment of newly diagnosed multiple myeloma (NDMM) has rapidly evolved. Quadruplet induction combining an anti-CD...
Pulmonary complications in acute myelogenous leukemia in post allogenic hematopoietic stem cell transplant period and yield of bronchoalveolar lavage and biopsy- single center experience
Abstract Background Pulmonary complications occur in 40-80% of acute myeloid leukemia (AML) and hemopoietic stem cell transplant (HSCT) patie...
Targeting of tumor antigen CD38 and stress antigens MICA/B by CAR T cells provides a unique approach for the comprehensive treatment of multiple myeloma
Abstract Introduction: Recently approved autologous chimeric antigen receptor (CAR) T-cell therapies (Abecma® and Carvykti®) have demonstrat...
Impact of early bacteremia on clinical outcomes following allogeneic hematopoietic cell transplantation with post-transplant cyclophosphamide-based gvhd prophylaxis
Abstract Background Bloodstream infections (BSIs) remain a significant cause of morbidity and mortality following allogeneic hematopoietic c...
Hemoglobin SC disease: Clinical analysis from the Georgia comprehensive sickle cell center at grady memorial hospital, Atlanta, Georgia.
Abstract Background: Hemoglobin (Hb) SC disease is a compound sickle cell variant that affects about 25% of patients with sickle cell diseas...
Impact of immunoglobulin supplementation on infection rates in myeloma patients receiving novel immunotherapies
Abstract Infections remain a major challenge in the management of patients with multiple myeloma (MM), associated with significant morbidity...
Trends and disparities in mortality from chronic lymphocytic leukemia in the geriatric population in the United States from 1999 to 2020: A nationwide analysis
Abstract Background: Chronic Lymphocytic Leukemia (CLL) is the most prevalent leukemia among adults in Western populations, disproportionate...
Impact of MDS-associated mutations and age on outcomes in NPM1-mutated AML
Abstract The current European Leukemia Net guidelines (ELN22) classify AML patients with intermediate-risk cytogenetics and MDS-associated m...
Nivolumab and pembrolizumab in treatment of relapsed or refractory classical Hodgkin lymphoma: Systematic review and meta-analysis of clinical trials
Abstract Introduction: Relapsed or refractory (r/r) disease is seen in 20-30% patients with classic Hodgkin lymphoma (cHL), where 10-15% of...