Blood
Articles in this Issue
The role of Tet2-mutant clonal hematopoiesis in solid tumor immunology
Abstract Background: Clonal hematopoiesis (CH) is an age-related condition wherein somatic mutations in hematopoietic stem and progenitor ce...
Elevated p16INK4a expression in sickle cell disease correlates with diminished social functioning and reflects accelerated aging
Abstract Introduction People living with sickle cell disease (SCD) experience complications indicative of an accelerated...
Pre-clinical evaluation of surovatamig (AZD0486) in comparison to CD20xCD3 bispecific antibodies
Abstract Background Surovatamig is a novel, fully human IgG4 bispecific T-cell engager (TCE) targeting CD19 and CD3. Engineered with low CD3...
Efficacy and safety of pozelimab plus cemdisiran versus ravulizumab in patients with paroxysmal nocturnal hemoglobinuria who received prior C5 therapy
Abstract Background: Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-rare life-threatening disorder characterized by hemolysis. The cu...
Machine learning-guided optimization of anti-CD70 natural ligand-based CAR-lymphocytes for Acute Myeloid Leukemia
Abstract Introduction: Relapsed/refractory acute myeloid leukemia (AML) is a devastating disease with an urgent need for novel therapies. CD...
Intelligent bispecific BCMA-CD24 CAR-T cells for precision navigation and elimination of multiple myeloma
Abstract Introduction: The high relapse rate following BCMA CAR-T therapy remains a challenge in the treatment of multiple myeloma (MM). We...
MAPS-R: International consensus classification-guided revision of the mayo alliance prognostic system for systemic mastocytosis
Abstract Background: The International Consensus Classification (ICC) for systemic mastocytosis (SM) recognizes mast cell leukemia (MCL) and...
Pirtobrutinib outcomes in second-line (2L) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) after first-line (1L) cBTKi therapy: A pooled analysis from the BRUIN LOXO-BTK-18001 and BRUIN CLL-321 studies
Abstract Introduction: Patients with CLL/SLL commonly receive a covalent Bruton tyrosine kinase inhibitor (cBTKi) as 1L therapy. However, mo...
Radiation-free therapy for the initial treatment of good prognosis early non-bulky HL, defined by a low metabolic tumor volume and a negative interim PET after 2 chemotherapy cycles. a phase II prospective rafting trial
Abstract Patients (pts) with early-stage favorable Hodgkin Lymphoma (efHL) have a heterogeneous prognosis: most (70%) are cured with chemoth...
Efficacy, molecular and translational analysis of TP53-mutated HR-MDS with bexmarilimab and azacitidine: Updated results from the bexmab Phase 1/2 study
Abstract Introduction Bexmarilimab is a novel macrophage checkpoint inhibitor targeting Clever-1, a scavenger receptor e...
Prognostic impact of the simplified hlama score and treatment-related complications in primary gastric diffuse large b-cell lymphoma: A retrospective study from a latin American center
Abstract Introduction Primary gastric lymphoma (PGL) is a common site of extranodal diffuse large B cell lymphoma (DLBCL...
New drug targets for acute myeloid leukemia identified through a comprehensive analysis of the plasma protein
Abstract Acute myeloid leukemia (AML) is a malignant blood disease with a poor prognosis. Over the past decades, intensive chemotherapy and...
Association of combined IKZF1plus genotype and ABL1 mutations with outcomes in adult BCR::ABL1-positive acute lymphoblastic leukemia
Abstract Background Combining IKZF1plus genotyping and minimal residual disease status at three months of treatment helps refining risk stra...
BTK inhibition drives mobilization and compartmental shifts of CLL subclones
Abstract BACKGROUND Chronic lymphocytic leukemia (CLL) shows compartmentalization, whereby genetically or functionally d...
Subgroup analysis based on prior treatment from the Phase 3 allele study of tabelecleucel for epstein-barr virus-driven post-transplant lymphoproliferative disease
Abstract Background: Tabelecleucel is an off-the-shelf, allogenic Epstein-Barr virus (EBV)-specific cytotoxic T cell therapy for relapsed or...
Unusual laboratory manifestations of fibrinogen γ chain p.Ala108Gly genetic variant: A case report
Abstract Introduction: Fibrinogen is a dimeric glycoprotein with monomers composed of Aα, Bβ, and γ subunits, which contributes necessary me...
Efficacy of fixed-duration venetoclax-based regimens as first-line in chronic lymphocytic leukemia: A systematic review and meta-analysis of clinical trials
Abstract Background: Fixed-duration treatment regimens have emerged as a paradigm shift in first-line chronic lymphocytic leukemia (CLL) man...
Molecular predictors of survival in patients with myeloproliferative neoplasm-blast Phase (MPN-BP) treated with venetoclax and decitabine
Abstract Background. MPN-BP after chronic phase MPN is characterized by dismal outcome, with OS <6 mo. Owing to disappointing results...
Elranatamab for relapsed/refractory multiple myeloma – multi-centre real-world outcomes from the United Kingdom
Abstract Background Elranatamab is a humanised B-cell maturation antigen (BCMA)-CD3 bispecific antibody. It is available in England and Wales...
Efficacy of novel agents in the treatment of acute myeloid leukemia and myelodysplastic syndrome: A systematic review and meta-analysis
Abstract Introduction: Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) are two of the most common hematological disorders in...
Modifiable lifestyle factors in patients with myeloproliferative neoplasms in the California teachers study
Abstract Introduction: Myeloproliferative Neoplasms (MPNs) are a rare set of hematologic malignancies associated with thrombotic complicatio...
Real-world outcomes with CAR T-cell therapy for secondary central nervous system lymphoma are similar between patients with active versus historical involvement
Abstract Background: Secondary central nervous system large B-cell lymphoma (sCNSL) carriers a poor prognosis and is often refractory to sta...
The USP22-NAP1L1 deubiquitination axis in the pathogenesis of myelodysplastic syndromes
Abstract Background:Myelodysplastic syndrome (MDS) is a group of clonal hematopoietic system diseases with significant heterogeneity. Its pa...
Acute splenic sequestration in children with sickle cell diseases: A single-center experience from Saudi Arabia with proposed management guideline
Abstract Background Sickle cell disease (SCD) is a common inherited hemoglobin disorder with significant clinical impact worldwide. In Saudi...
Whole-genome sequencing (WGS)-based circulating tumor DNA (ctDNA) monitoring in diffuse-large B-cell lymphoma (DLBCL)
Abstract Introduction: Among Non-Hodgkin lymphomas (NHL), DLBCL is the most prevalent subtype (~30% of diagnoses). First-line (1L) chemoimmu...