Blood
Articles in this Issue
Phase l dose escalation and expansion of ziftomenib in combination with quizartinib in AML
Abstract Background and Significance: The menin-KMT2A interaction is a dependency in acute leukemia caused by either rearrangement of the KMT...
Preliminary analysis of a phase 2b, randomized, active-control study of flonoltinib maleate (FM) vs. ruxolitinib in intermediate-2 or high-risk myelofibrosis patients
Abstract Background Myelofibrosis (MF) is characterized by abnormal clonal expansion of hematopoietic stem cells driven by mutations JAK2, C...
Comparison of axi-cel versus liso-cel as 2nd line therapy for relapsed/refractory large B-cell lymphoma in real-life: A lysa study from the descar-T registry
Abstract Background Axicabtagene ciloleucel (axi-cel) and Lisocabtagene maraleucel (liso-cel), two anti-CD19 CAR T-cells...
Application of polycythemia vera guidelines in pediatric patient with erythrocytosis: A case series
Abstract Background Polycythemia vera (PV) is defined as an increase in red blood cells reflected as an increase in hemo...
Analysis of healthcare utilization costs prior to and after non-myeloablative haploidentical allogeneic stem cell transplantation in adults with sickle cell disease
Abstract Background: Despite robust advances in understanding of sickle cell disease (SCD) pathophysiology, therapeutic options for SCD pati...
Impact of IKZFplus status and ABL1 kinase domain mutations in patients with newly diagnosed Philadelphia-chromosome positive acute lymphoblastic leukemia receiving imatinib and chemotherapy followed by allogeneic SCT within GMALL07/03
Abstract Background Several study groups have demonstrated, that alterations in the IKZF1gene at diagnosis and the presence of ABL1 mutations...
A converging crisis: Long-term mortality trends in respiratory failure and anemia inthe United States, 1999–2023
Abstract Background: Respiratory failure and anemia are major contributors to mortality in the United States, particular...
Geographic and temporal trends in sickle cell disease hospitalizations in New York State
Abstract Introduction: Sickle cell disease (SCD) is the most common inherited blood disorder in the United States, disproportionately affect...
Patterns of care in second line management of nodal peripheral T-cell lymphoma from the lymphoma epidemiology of outcomes (LEO) and molecular epidemiology resource (MER) prospective cohort Study
Abstract Background Nodal peripheral T-cell lymphomas (nPTCLs) are a challenging group of non-Hodgkin lymphomas that frequently recur after o...
Efficacy and safety of pivekimab sunirine in blastic plasmacytoid dendritic cell neoplasm in patients with prior or concomitant hematologic malignancy: Results from the cadenza study
Abstract Introduction: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy that primarily i...
Comparable outcomes in patients aged ≥70 vs. <70 undergoing allogeneic transplantation with fludarabine and melphalan conditioning and post-transplant cyclophosphamide
Abstract Background: Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are predominantly diseases of older adults, with media...
Generative AI and knowledge in hematological infectious malignancies: Generating synergies
Abstract Introduction: Patients with hematological malignancies face a high risk of infectious complications due to immunosuppressive treatm...
Minimal residual disease as a prognostic marker in chronic lymphocytic leukemia: A meta-analysis across chemoimmunotherapy and targeted therapies
Abstract Background Minimal Residual Disease (MRD) assessment is increasingly utilized in the management of Chronic Lymp...
Prognostic impact of cognitive and other impairments in older adults with acute myeloid leukemia (AML) participating in a geriatric assessment-guided treatment selection trial
Abstract Background: Impairments on geriatric assessment (GA) are common in older adults with AML; hence we designed a trial that used GA gui...
INO-transit: Inotuzumab ozogamicin treatment prior to chimeric antigen receptor T-cell therapy in Relapsed/Refractory B-cell acute lymphoblastic leukemia: Real-world patient characteristics and outcomes in Spain, the UK and US
Abstract Introduction:Inotuzumab ozogamicin (InO) is a CD22-targeted antibody drug conjugate approved for relapsed/refractory B-cell acute l...
Final analysis of the randomized phase 2 ROSEWOOD study of zanubrutinib + obinutuzumab vs obinutuzumab monotherapy in patients with relapsed/refractory follicular lymphoma
Abstract Introduction: While treatment advances have improved outcomes in follicular lymphoma (FL), many patients experience multiple relaps...
Loss of ADAR1-mediated RNA editing disrupts lineage fidelity in human T cell development by inducing interferon response genes
Abstract T lymphocytes originate from bone marrow hematopoietic stem cells (HSC) that migrate to the thymus for maturation, selection, and s...
Cytokine score for prognostication of newly diagnosed multiple myeloma
Abstract Introduction Multiple myeloma (MM) is clinically heterogeneous, and therapeutic response is profoundly influenced by the complex cy...
Feasibility and efficacy of daratumumab-vcd in transplant-ineligible elderly patients with newly diagnosed multiple myeloma: First results from the multicenter GMMG-dada study
Abstract Background: Daratumumab (Dara) combined with either VRd or Rd is a standard treatment for transplant-ineligible patients with newly...
Innate immune dysregulation in monocytes in sickle cell disease
Abstract Background : Sickle cell disease (SCD) is the most common genetic hematological disorder affecting ~100,000 people in the United St...
CTA311, a universal anti-CD19 CAR t-cell therapy with improved persistence for patients with CD19+ relapsed/ refractory (R/R) b-cell acute lymphoblastic leukemia (B-ALL)
Abstract R/R B-ALL remains difficult to treat with a dismal prognosis, even in the era of autologous CAR-T and targeted therapies. Autologou...
Interpretable deep learning predicts polycythemia vera and identifies novel genomic associations
Abstract Lowering the haemoglobin cut-off for polycythaemia vera (PV) has markedly increased suspected PV referrals. Polycythemia Vera (PV)...
The MEASURE Genome Atlas: Acute Myeloid Leukemia at diagnosis and complete remission
Abstract Introduction: Genetic profiling is essential for optimal management of patients with acute myeloid leukemia (AML). Whole genome seq...
Platelet factor 4 (PF4) modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes
Abstract Introduction: Upon sensing pathogens, platelets (plt) release high concentrations of the positively charged chemokine PF4 from thei...
TCF3::hlf-positive b-ALL: Largest cohort study to date reveals unique molecular landscape and treatment challenges
Abstract Background: TCF3::HLF-positive B-cell acute lymphoblastic leukemia (B-ALL) represents one of the most aggressive and treatment-refr...