Blood
Articles in this Issue
Targeting lysosomes to overcome albumin-mediated proteasome inhibitor resistance in multiple myeloma
Abstract Background: Proteasome inhibitors (PIs) are a cornerstone of multiple myeloma (MM) therapy, exploiting the high rate of immunoglobu...
Myelodysplastic syndrome in Tanzania; The current status of management
Abstract Introduction Myelodysplastic syndromes (MDS) are hematopoietic disorders characterized by ineffective hematopoiesis, peripheral cyt...
Outcome of patients with large B-cell lymphoma relapsing after second-line CAR-t: Insights from the descar-t registry
Abstract Background: Relapse after CAR T-cell therapy in large B-cell lymphoma (LBCL) is associated with poor prognosis, lacking a clear sal...
Isatuximab (Isa) subcutaneous (SC) via an on-body injector (OBI) vs isa intravenous (IV), plus pomalidomide and dexamethasone (Pd) in relapsed/refractory multiple myeloma (RRMM): East asia subgroup results from the randomized, non-inferiority, phase 3 iraklia study
Abstract Background: Intravenous (IV) isatuximab plus pomalidomide and dexamethasone (Isa-Pd) is approved for treatment in patients with rel...
Unmasking the unknown: A case of bone marrow carcinomatosis with elusive primary
“comparative outcomes of midline versus peripheral intravenous catheters: A systematic review and meta-analysis.”
Abstract Background: Intravascular catheters are indispensable to contemporary inpatient therapy and peripherally inserted central catheters...
Loss of endothelial mir-126 drives age-related reduction of hematopoietic activity
Abstract Aging hematopoietic stem cells (HSCs) expand but their functional capacity declines. To prioritize the relative contributions of in...
Low adherence to cervical cancer screening guidelines among women survivors after allogeneic hematopoietic cell transplantation: Predictors and practice gaps from a single-center analysis
Abstract Introduction: Allogeneic hematopoietic cell transplantation (alloHCT) survivors are at risk for secondary malignancies (SM), such a...
Primary analysis of the phase 3 randomized trial of selinexor and lenalidomide versus lenalidomide alone as maintenance therapy post autologous stem cell transplant for patients with newly diagnosed multiple myeloma (ALLG MM23; SEALAND)
Abstract Introduction: Selinexor (S) is an oral selective exportin 1 inhibitor approved in relapsed multiple myeloma (MM) in combination with...
Unequal outcomes: The role of institutional setting in the management of primary CNS lymphoma
Abstract Background: Primary central nervous system lymphoma (PCNSL) is a rare and highly aggressive non-Hodgkin lymphoma confined to the br...
Impact of oral eicosapentaenoic acid on veno-occlusive disease/sinusoidal obstruction syndrome onset prevention: Single-center retrospective analysis
Abstract Introduction Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a serious complication following allogeneic hemato...
Biomarker analysis to unravel mechanisms of resistance to glofitamab monotherapy in large B cell lymphoma
Abstract Background: Glofitamab, a CD20-CD3 T-cell bispecific, has demonstrated high and durable complete responses (CR) in patients (pts) w...
Sodium-glucose cotransporter-2 inhibitors may modulate complement pathway activation in paroxysmal nocturnal hemoglobinuria
Abstract PNH is a bone marrow failure syndrome characterized by intravascular hemolysis and thrombotic proclivity. Complement inhibitors (CI...
From photosensitivity to cure: Hematopoeitic stem cell transplant for congenital erythropoeitic porphyria in a low-resource setting
Abstract Abstract: Congenital Erythropoeitic Porphyria is extremely rare autosomal recessive disorder caused by deficiency of uroporphyrin s...
Prevalence of iron deficiency anemia associated with malabsorption syndromes among African American women
Abstract Introduction: Iron deficiency anemia (IDA) is one of the most prevalent blood disorders in the world, dispropor...
Endocrine adverse events following CAR-T cell therapies: A pharmacovigilance analysis in the real-world setting utilizing the faers database
Abstract Background: CAR-T cell therapies have transformed treatment for hematologic malignancies. While hematologic and cytokine-related to...
A phase II investigator-initiated frontline trial of evorpacept (ALX148), lenalidomide and rituximab for high tumor burden indolent b-cell non-Hodgkin lymphoma
Abstract Introduction . We have recently completed a phase I trial of evorpacept (formerly known as ALX148), a novel high-affinity signal reg...
Phase II, single-arm, open-label, multicenter study: Efficacy of adjunctive Bruton's tyrosine kinase inhibitor (BTKi) zanubrutinib and chimeric antigen receptor (CART) in aggressive B-cell non-hodgkins lymphoma (aNHL)
Abstract Background: Resistance to CART has been linked to T-cell exhaustion with suppressive effects on the tumor microenvironment (TME), r...
Feasibility of impementing pre-marital genetic counseling in kano, northern Nigeria using the cfir-eric model
Abstract Background: Sickle cell disease (SCD) is an autosomal recessive disorder where premarital genetic counseling (PGC) and screening ca...
Effect of post-transplant cyclophosphamide on outcomes in stem cell transplant recipients with myelofibrosis
Abstract Background: Allogenic hematopoietic stem cell transplantation (AHSCT) for myelofibrosis (MF) patients (pts) can involve several dis...
Successful first-line use of pemigatinib in myeloid/lymphoid neoplasm with FGFR1 rearrangement: Clinical insights
Abstract Introduction Myeloid/lymphoid neoplasms (MLNs) with fibroblast growth factor receptor 1 (FGFR1) rearrangement (MLNFGFR1) comprise a...
Addressing psychological burden in patients newly diagnosed with lymphoma or myeloma: Patient perspectives on potential interventions
Abstract Background: More than half of patients newly diagnosed with lymphoma or myeloma experience clinically significant anxiety or depres...
Shared decision making for immune thrombocytopenia (ITP) treatment: Data from the ITP natural history study registry
Abstract Introduction: Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder associated with an increased risk for bleeding. Vari...
Inotuzumab ozogamicin then blinatumomab for older adults with newly diagnosed, ph-negative, CD22-positive, B-cell acute lymphoblastic leukemia: Extended follow-up of alliance for clinical trials in oncology A041703 cohort 1 reveals durable remission and survival
Abstract Background: Older adults with newly diagnosed ALL treated with conventional chemotherapy have poor survival due to high rates of to...
The Mayo Clinic enterprise experience and outcomes of perioperative utilization of recombinant factor VIIa (rFVIIa, NovoSeven®)
Abstract Background: Recombinant activated factor VIIa (rFVIIa, NovoSeven®) is an FDA-approved medication for managing b...