Blood
Articles in this Issue
Cardiac risk factors and cardiac events in patients with newly diagnosed amyloid light chain (AL) amyloidosis from the Phase 2 aquarius study of daratumumab (DARA) plus bortezomib, cyclophosphamide, and dexamethasone (D-VCd)
Abstract Introduction AL amyloidosis is a rare disorder caused by amyloid fibrils produced by clonal plasma cells, leadi...
Feasibility of collecting social determinants of health data in the frontline pediatric acute lymphoblastic leukemia (ALL) trial AALL1731: A report from the Children's oncology group
Abstract Background : Poverty-exposed children with B-acute lymphoblastic leukemia (B-ALL) are more likely to relapse, and long-term survivo...
Rapid, efficient and durable fetal hemoglobin production following CS-101 treatment in transfusion-dependent β-thalassemia participants: An autologous, ex vivo edited CD34+ stem cell product using the innovative transformer base editor (tBE)
Abstract Background: β-hemoglobinopathies, such as β-thalassemia and sickle cell disease (SCD), result from mutations in the β-globin gene (...
BET inhibition targets pathogenic interstitial macrophages to limit antibody mediated fibrosis in bronchiolitis obliterans chronic gvhd
Abstract Introduction: Chronic graft-versus-host disease (cGVHD) is a major cause of late mortality in allogeneic-hematopoietic stem cell tr...
Intra-sample flow cytometry analysis identifies upregulated interleukin-6 receptor (CD126) as a potential therapeutic target in gain(1q) myeloma
Abstract Introduction: Interleukin-6 (IL6) is a proliferative factor in multiple myeloma (MM) and important for plasma c...
Genetic analysis and clinical correlations in marginal zone lymphoma
Abstract Background: Marginal zone lymphoma (MZL) is a heterogeneous group of indolent B-cell malignancies with distinct molecular landscape...
Real-world effectiveness and safety of hydroxyurea in adults with hemoglobin SC disease: A retrospective cohort study in Quebec, Canada
Abstract Background Hemoglobin SC disease (HbSC) is the second most prevalent genotype of sickle cell disease (SCD) worl...
Innate immune lectins shape anti-blood group antibody development and transfusion outcomes
Abstract Introduction Anti-ABO(H) antibodies are the primary immunological barrier in both transfusion and transplantation. Although these a...
Bi-allelic TET2 alterations are frequently found in NPM1 mutated AML and constitute a distinct subgroup with unfavorable prognosis
Abstract Background: Mutations (mut) in TET2 and NPM1 are common in myeloid neoplasms, with NPM1mut defining a distinct genetic entity in ac...
Tropomyosin 1 promotes platelet adhesion and clot contraction to inhibit thrombosis
Abstract Background: Failures in thrombosis prevention and treatment demand novel therapeutic approaches. We hypothesized that novel genetic...
Impact of race and socioeconomics on access to T-cell engaging therapy in US patients with relapsed/refractory multiple myeloma (RRMM)
Abstract Background People of color (POC) and patients (pts) from socioeconomically disadvantaged backgrounds often face financial, geograph...
Access to innovative treatment for paroxysmal nocturnal hemoglobinuria in low- and middle-income countries
Abstract Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, chronic, and life-threatening blood disorder characterized by unco...
A phase 2 trial of 89Zr-DFO-daratumumab for CD38-targeted imaging of multiple myeloma (the iMMunoPET study)
Abstract Background Evaluation of multiple myeloma disease burden and response to therapy are currently suboptimal. For instance, ~30% of mye...
A deep dive into the bone marrow plasma proteome by optimized extracellular vesicle enrichment
Abstract Communication between leukemic cells and the bone marrow microenvironment is thought to play a pivotal role in acute lymphoblastic...
Clinical management of congenital thrombotic thrombocytopenic purpura in Latin America: Expert consensus from a modified Delphi panel
Abstract Background Congenital thrombotic thrombocytopenic purpura (cTTP), also referred to as Upshaw-Schulman syndrome or hereditary TTP (h...
Novel trajectory-informed mendelian randomization demonstrates consistent causal protective effect of fetal hemoglobin on clinical outcomes in children with sickle cell disease
Abstract Introduction: Fetal hemoglobin (HbF) plays a critical role in modulating the clinical severity of sickle cell disease (SCD). Severa...
US cost consequence and time toxicity model for advanced therapies in the treatment for Relapsed/Refractory third-line or later diffuse large B-cell lymphoma: A comparison of axicabtagene ciloleucel with bispecific antibodies
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is the most frequently diagnosed lymphoma and often cured in first- or second-lin...
Epcoritamab monotherapy demonstrates promising efficacy in patients with Richter transformation (RT): 2-year follow-up results from arm 2A of the phase 1b/2 EPCORE CLL-1 trial
Abstract Introduction: RT is a rare, often fatal, transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, mostly d...
Outcomes from the Multicenter ACCRU-LY-1804/CARiBOU (Cytarabine, Acalabrutinib and Rituximab integrated with Bortezomib-based Outpatient therapy) Trial in 1st line Mantle Cell Lymphoma
Abstract Introduction: First-line therapy for mantle cell lymphoma (MCL) represents a critical opportunity for clinical benefit via sustained...
Thrombopoietin receptor agonists combined with intensive immunosuppressive therapy improve outcomes in elderly patients with severe aplastic anemia: A single-center retrospective study
Abstract Introduction: Intensive immunosuppressive therapy (IST) has significantly improved the prognosis of elderly patients with severe ap...
Socio-economic deprivation in paediatric patients with B cell -acute lymphoblastic leukaemia : A possible modifiable risk factor based on the real world data from a retrospective survival analysis from the national registry in England
Abstract Introduction One of the leading reasons for the improved survival rate of paediatric ALL has been the main use of risk-stratified t...
CAR T cells converge on a distinct transcriptional state over time in patients with diverse hematologic malignancies
Abstract Chimeric antigen receptor (CAR) T cells directed to cancer cells act as a living drug in patients and have the potential to induce...
FAST4TMA: A national rapid ADAMTS13 testing initiative for TMA patients — 2025 update
Abstract Background: Immune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy (TMA) driven by ADAM...
Safety and efficacy of carfilzomib-based combinations in relapsed/refractory multiple myeloma patients in a real-world Setting : Results of a french single academic center retrospective study.
Abstract Background Carfilzomib (K), a next-generation proteasome inhibitor, has proven strong efficacy in Multiple Myeloma (MM), and has de...
Minimal residual disease-guided venetoclax plus rituximab for patients with previously untreated chronic lymphocytic leukemia (VERITA PALG-CLL5): primary endpoint analysis of the prospective, multicenter, Phase 2 trial
Abstract Background: Fixed-duration regimens combining the selective BCL-2 antagonist venetoclax with an anti-CD20 antibody are currently th...