Blood
Articles in this Issue
Deciphering the origin and plasticity of circulating endothelial cells reveals a systemic angiogenic program in breast cancer
Abstract Endothelial cells line the inner surface of blood and lymphatic vessels and play key roles in vascular function. Circulating endoth...
Characteristics and therapies for pure red cell aplasia in patients with chronic lymphocytic leukemia (CLL) - a real world analysis from trinetx database
Abstract INTRODUCTION Pure red cell aplasia (PRCA) is characterized by normochromic normocytic anemia, reticulocytopenia...
Multicenter study of the ion AmpliseqTM Liverpool Lymphoid Network community NGS panel for molecular characterization of lymphoid malignancies
Abstract Introduction Molecular testing is increasingly essential in lymphoid malignancies to support future efforts in...
Outcomes of percutaneous coronary intervention in patients with multiple myeloma: A national inpatient analysis
Abstract Background: Multiple myeloma (MM) is a plasma cell malignancy associated with a high burden of comorbidities, including chronic kid...
Paralog interdependency between MEF2C and MEF2D sustains protein stability and leukemia maintenance in KMT2A-rearranged AML
Abstract Acute myeloid leukemia (AML) is characterized by lineage infidelity, transcriptional dysregulation, and frequent resistance to stan...
The presence of secondary type or DNMT3A mutations does not affect prognosis in NPM1 mutated AML treated with intensified fludarabine-high dose cytarabine and idarubicine (FLAI) induction regimen.
Abstract Background: Acute myeloid leukaemia (AML) with mutated Nucleophosmin 1 (NPM1) is recognized as a distinct subtype of AML in the 202...
IRF4 maintenance in multiple myeloma is conserved in de novo-derived inobrodib resistance, conferring cross resistance to immunomodulatory drugs
Abstract Multiple myeloma (MM) is the second most common hematological malignancy. It is marked by widespread transcriptional dysregulation...
Enhanced procoagulant activity of phosphatidylserine-positive platelets in antiphospholipid syndrome
Abstract Introduction: Antiphospholipid syndrome (APS) is defined by thrombosis or fetal loss in the presence of persistent circulating anti...
Cost-effectiveness of post-transplant gilteritinib maintenance in MRD-positive FLT3-ITD Acute Myeloid Leukemia: A microsimulation model based on the morpho trial
Abstract Background: FLT3-ITD mutations in acute myeloid leukemia (AML) confer a high risk of relapse following initial remission. While pos...
Unmasking HLH: A BCOR mutation as the hidden driver of immune dysregulation and fulminant hepatic failure
Abstract Introduction Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome triggered by infections, mal...
Treatment of steroid-refractory acute graft-versus-host disease by mesenchymal stromal cells: The francophone society of bone marrow transplantation and cellular therapy (SFGM-TC) experience in 43 patients
Abstract Acute graft-versus-host disease (aGvHD) is the main cause of treatment-related mortality after allogeneic stem cell transplantation...
Psychosocial well-being in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) and their caregivers: A prospective study
Abstract Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment for many hematologic malignancie...
Retrospective analysis of efficacy and safety of romiplostim N01 in the treatment of chemotherapy-induced thrombocytopenia (CIT) in solid tumors
Abstract Background: Chemotherapy-induced thrombocytopenia (CIT), a common hematological toxicity in cancer treatment, o...
Temporal external validation of an individuals machine learning clinical decision support prediction tool for hematopoietic cell transplantation for sickle cell disease
Abstract Background: Hematopoietic cell transplantation (HCT) for sickle cell disease (SCD) has excellent outcomes but heterogeneous inter-p...
Real-world risk of vascular events in patients with myeloproliferative neoplasms compared to the danish general population
Abstract Introduction: Treatment in myeloproliferative neoplasms (MPN) aims to lower the risk of thrombotic events, alleviate MPN-related sy...
Invisible wounds: Suicide in military service members with lymphoma
Abstract Background: Although U.S. military service members (SMs) with lymphoma have demonstrated superior survival compared to the general...
Clinical outcomes of tisagenlecleucel in patients with relapsed/refractory follicular lymphoma (r/r FL): Phase 2 ELARA 5-year update
Abstract Background: Tisagenlecleucel, an autologous anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has been approved in the Unite...
Association between cilta-cel dose and efficacy and toxicity outcomes for patients with Relapsed/Refractory multiple myeloma (RRMM): A real-world analysis from the US multiple myeloma immunotherapy consortium
Abstract Introduction: Ciltacabtagene autoleucel (cilta-cel) is a highly effective BCMA-redirected CAR T-cell therapy for RRMM. While the pi...
Trial-in-progress: A phase 2 randomized trial of remodeling intestinal microbiota using fecal microbiome transplant (FMT) among recipients of chimeric antigen receptor T cells (CAR T)
Abstract Background: CAR T cell therapy has been transformative in the treatment of B cell lymphomas, with overall response rates (ORR) reac...
Restoration of inflammatory and transcriptional axes via temporal TNFα and CDK8/19 modulation enhances hemogenic specification from human iPSCs
Abstract Background Generating hematopoietic stem and progenitor cells (HSPCs) from human induced pluripotent stem cells (iPSCs) holds transf...
Experiences of patients with multiple myeloma enrolled in high-deductible health plans: A mixed-methods study
Abstract Introduction: Nearly half of U.S. private-sector employees are enrolled in high-deductible health plans (HDHPs), which can be cost-...
Letermovir prophylaxis for cytomegalovirus and immune reconstitution after allogeneic hematopoietic stem cell transplantation: A single-center real-world study
Abstract Introduction: Letermovir prophylaxis is essential for preventing cytomegalovirus (CMV) reactivation in adult hematopoietic stem cel...
Ibrutinib in combination with rituximab, methotrexate (MTX), vincristine, and procarbazine (R-MPV/i) for newly diagnosed primary CNS lymphoma (PCNSL)
Abstract Background: The R-MVP regimen results in a 66% complete response rate (CRR) in newly diagnosed PCNSL. The Bruton's tyrosine kinase...
Determinants of survival in t-cell large granular lymphocytic leukemia (T-LGL): Analysis of a real-world pooled database
Abstract Background: T-LGL is a rare and indolent lymphoproliferative disorder characterized by the clonal expansion of cytotoxic T cells. A...
Efficacy of zanubrutinib maintenance in patients with primary CNS lymphoma achieving complete response: A phase II study
Abstract Efficacy of Zanubrutinib Maintenance in Patients with PCNSL Achieving Complete Response: A Phase II Study Yan Ma1，Zhiguang Lin, Ji...