Blood
Articles in this Issue
Incidence and outcomes of Clostridioides difficile infection in BCMA and CD19 CAR-T cell therapy.
Abstract Background: Clostridioidesdifficile infection (CDI) represents a significant infectious complication in both Chimeric Antigen Recep...
Synergistic effect of HLA evolutionary divergence and post-transplant biomarkers on non-relapse mortality prediction in adult haploidentical hematopoietic stem cell transplantation
Abstract Background: In hematopoietic stem cell transplantation, post-transplant biomarkers are recognized as reliable prognostic indicators...
Outcomes of autologous stem cell transplantation using busulfan-melphalan conditioning with pharmacokinetic monitoring for relapsed diffuse large B-cell lymphoma
Abstract Background: Autologous stem cell transplantation (ASCT) remains an important option for patients with late relapses of diffuse larg...
Enhancing CD33.CAR NK cell therapy for acute myeloid leukemia through TGFβ imprinting and NKTR-255
Abstract Background: Acute myeloid leukemia (AML) accounts for 25% of acute leukemias in children and 33% in adults. CD33 is overexpressed i...
Precision In Vivo CAR-T generation via CLAMP-enabled mRNA delivery: Toward scalable and translatable cell therapy
Abstract Background:Chimeric Antigen Receptor (CAR) T cell therapies have transformed the treatment landscape of hematological malignancies...
Evaluation of outcomes and toxicities of loncastuximab tesirine (Lonca) in relapse/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL): Real-world data analysis (RWDA) from 10 US academic centers
Abstract Background: In R/R DLBCL/FL, T-cell engager therapy (TCET) using chimeric antigen receptor T-cell therapy (CART) or bispecific anti...
Good report of secondary allogeneic hematopoietic stem cell transplantation in patients with refractory/relapsed Acute Myeloid Leukemia
Abstract Objective: Post-transplant relapse in AML was a challenging clinical issue, with limited intervention options currently available....
Real-world implementation of bispecific antibody delivery in community oncology: Overcoming operational barriers through partnerships & interprofessional education
Abstract Background: T-cell redirecting bispecific antibodies have emerged as a highly effective, off-the-shelf treatmen...
Healthcare resource utilization with prophylactic intravenous anakinra following anti-CD19 CAR-T therapy in B-cell lymphoma: A Canadian single-center quality improvement experience.
Abstract Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy has transformed B-cell lymphomas treatment. Its use is complicated b...
Beyond the unknown: Leveraging machine learning to predict adverse outcomes in pregnant women with aplastic anemia from a representative nationwide cohort
Abstract Introduction Aplastic anemia (AA), a rare disorder characterized by bone marrow failure and pancytopenia, poses exceptionally high...
The incidence of complications related to central venous line placement in patients newly diagnosed with acute lymphoblastic leukemia
Abstract Introduction Central venous lines (CVLs) are crucial to the treatment of acute lymphoblastic leukemia (ALL). They are utilized for...
Efficacy and safety profile of inaticabtagene autoleucel in Chinese patients with B-cell acute lymphoblastic leukemia: Insights from real-world data
Abstract Introduction: Inaticabtagene autoleucel (Inati-cel), featuring a CD19 scFv derived from the HI19a clone and a 4-1BB/CD3-ζ costimula...
Anti-TIM3 with hypomethylating agent revives NK and cytotoxic CD4+ T cell activity in patients with AML or MDS
Abstract Recent clinical trials in AML combining immune checkpoint inhibitors (anti-PD1, anti-CTLA4) with hypomethylating agents have yielde...
Medical and perioperative management of acute and subacute heparin-induced thrombocytopenia in adults requiring urgent cardiopulmonary bypass surgery.
Abstract Heparin-induced thrombocytopenia (HIT) is a highly prothrombotic disorder and presents a unique challenge for patients undergoing u...
MGMT-silencing as a novel biomarker in AML: Rational application of a dual alkylator-DNA crosslinker for targeted therapy
Abstract Acute Myeloid Leukemia (AML) remains a therapeutically challenging malignancy with poor outcomes. Standard chemotherapy regimens or...
Real-world experience with varnimcabtagene autoleucel (murine CD19 CAR-T) from India: A step towards enhanced patient access with excellent safety and efficacy
Abstract Background: Varnimcabtagene autoleucel (IMN-003A), an autologous second-generation CAR T-cell product with a 4-1BB co-stimulatory d...
The impact of first line tyrosine kinase inhibitors (TKI) on the development of resistance mutations in patients with Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL)
Abstract Introduction: Since the introduction of ABL-specific tyrosine kinase inhibitors (TKI), the prognosis for adults...
Temporal trends in treatment outcomes of acute lymphoblastic leukemia in Japan: Progress and unmet needs
Abstract Background The prognosis of acute lymphoblastic leukemia (ALL) has improved globally with advances in diagnostic techniques and the...
Characteristics of the spatio-temporal distributions of chimeric antigen receptor T cells based on real-world evidence
Abstract Introduction Chimeric antigen receptor (CAR) T cell therapy, which involves the reinfusion of a patient's T cells into their body a...
Real-world insights into diffuse large B-cell lymphoma from EHR-derived data in Germany and the United Kingdom
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, accounting for approximatel...
Real-world cardiovascular risk of ponatinib in chronic Phase CML: Insights from a nationwide Korean claims-based cohort study
Abstract Background Ponatinib was introduced relatively late in Korea and has been reimbursed under the national health insurance system sin...
Assessing quality metrics in sickle cell disease: A multicenter review of community hospitals in southwestern Ontario from 2017-2024.
Abstract Background: In Ontario, Canada, quality standards have been developed to promote the timely and effective management of patients wi...
Multidimensional profiling of dendritic cell and monocyte subsets in sickle cell anemia: Correlation with clinical and inflammatory parameters
Abstract Dendritic cells (DCs) and monocytes (Mo) are key components of the innate immune system, playing essential roles in initiating, pol...
Assessing the cost & cost-effectiveness of next-generation sequencing for the diagnosis of hematological malignancies in children, adolescence & young-adults: A systematic literature review
Abstract Next-generation sequencing (NGS) is a cumulation of novel diagnostic modalities that can sequence entire parts of a cell in one sam...
Asciminib (ASC) in chronic myeloid leukemia in chronic Phase (CML-CP): Efficacy and safety results of the Phase 2 ASC2ESCALATE trial in the cohort of patients (pts) with 1 prior tyrosine kinase inhibitor (TKI)
Abstract Introduction ASC previously demonstrated efficacy, safety, and tolerability in newly diagnosed (1L) CML-CP and CML-CP after ≥2 prio...