Blood
Articles in this Issue
Monoclonal gammopathy of indeterminate potential (MGIP) as a stable premalignant entity preceding hematologic malignancy
Abstract INTRODUCTION Recent advances in mass spectrometry (MS) have enabled the detection of low-level monoclonal immunoglobulins previousl...
Barriers to receiving CAR T-cell treatment among patients with non-Hodgkin lymphoma who were deemed eligible for CAR T-cell therapy
Abstract Background: Advances in non-Hodgkin lymphoma (NHL) treatment options, such as chimeric antigen receptor T-cell therapies (CAR T) an...
Exploring the multi-target pharmacology of ginseng against Acute Myeloid Leukemia by integrating single-cell sequencing, molecular docking, and network pharmacology
Abstract Background: Acute myeloid leukemia (AML) is a heterogeneous disease. It is characterized by the rapid clonal expansion of abnormall...
Discovery of the transcription factor ZNF683/hobit as a central regulator of pathogenic T cell proliferation in acute gvhd
Abstract Background: Severe acute GVHD (aGVHD) remains a major cause of mortality after transplant, especially with CNI/MTX prophylaxis. How...
Real-world effectiveness and safety outcomes by age, comorbidities, and frailty among relapsed or refractory (R/R) Mantle Cell Lymphoma (MCL) patients treated with brexucabtagene autoleucel (brexu-cel)
Abstract Introduction: Brexu-cel is a CAR T-cell therapy approved in the US for adults with R/R MCL and has demonstrated durable responses an...
A mixed methods evaluation of American society of Hematology's (ASH) clinical guidelines
Abstract Introduction: Clinical guidelines are evidence-based recommendations for diagnosing and treating a medical condition. Guideline rec...
Social determinants of health and long-term survival in chronic lymphocytic leukemia/small lymphocytic lymphoma: A population-based analysis of 118,667 patients
Abstract Background: Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) exhibits heterogeneous outcomes influenced by biologi...
Real-world one-month mortality and bleeding outcomes with caplacizumab in thrombotic thrombocytopenic purpura: A propensity-matched cohort study
Abstract Background Thrombotic Thrombocytopenic Purpura (TTP) is a rare, typically acquired disorder due to an immune-mediated deficiency of...
Outcomes of second line platinum salvage and autologous stem cell transplant compared to CD19 CAR-T in patients with Relapsed/Refractory primary mediastinal B-cell lymphoma: A multi-center, retrospective analysis
Abstract Introduction: Primary mediastinal B-Cell lymphoma (PMBCL) is a rare form of large B-Cell lymphoma (LBCL) with around 90% of patient...
Effects of golidocitinib and gecacitinib in mouse models of primary and secondary hemophagocytic lymphohistiocytosis
Abstract Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening cytokine storm syndrome caused by immune hyperactivati...
Monoclonal and polyclonal circulating plasma cells (CPCs) are linked to disease spread in multiple myeloma
Abstract Multiple myeloma (MM) is a hematological malignancy characterized by clonal expansion of plasma cells (PC) in the bone marrow (BM),...
Changes in disease responses after discontinution of tyrosine kinase inhibitors (TKI) for pregnancy in established chronic myeloid leukaemia (CML): Evidence for the basis of advice for women of child-bearing age
Abstract The ability of women of child-bearing age to have successful pregnancies despite their diagnosis of chronic myeloid leukaemia (CML)...
Prospective registry of pediatric cellular therapy patients at risk for endothelial dysfunction, sinusoidal obstruction syndrome and/or multi-organ dysfunction syndrome(POEM): pmods as a screening tool for endotheliopathies and critical care admission risk in pediatric HCT patients.
Abstract Background Pediatric patients undergoing hematopoietic cell transplantation (HCT) may develop life-threatening complications and ne...
Scalable, Antibody-Free Lipid Nanoparticle Achieves Human HSPC-Selective mRNA Delivery In Vivo Without Conditioning
Abstract Cell and gene therapies for hematologic malignancies currently rely on mobilization, apheresis, ex vivo genetic manipulation, and r...
Enrichment of rare pathogenic variants in common cancer predisposition genes in lymphatic malignancy: A comprehensive analysis of 2,138 cases
Abstract Introduction: The link between rare, inherited pathogenic variants (PVs) and an increased risk of developing specific malignancies,...
Targeting B-cell lymphoma surface protein with a novel peptide: Therapeutic potential and clinical implications
Abstract Background: B-cell lymphoma has significantly improved patient survival, however, approximately 30% of patients develop relapsed/re...
Red blood cell transfusions for adolescent patients with sickle cell disease & short stature: A long term follow up study
Abstract BACKGROUND: Children with sickle cell disease (SCD) commonly have delayed or impaired growth. Current evidence suggests that childr...
Trial in progress: A pivotal Phase 3 study to investigate efficacy, safety, and tolerability of mavorixafor in participants with primary chronic neutropenia – trial update
Abstract Background Primary chronic neutropenia (CN) is a rare immunodeficiency disorder characterized by absolute neutrophil count (ANC) &a...
Multiple ASXL1 mutations and G646fs alterations confer increased risk of leukemic Transformation in patients with myelofibrosis
Abstract Introduction The epigenetic regulator additional sex combs-like 1 (ASXL1) is the most commonly mutated high molecular risk gene in m...
Metabolic reprogramming drives acquired venetoclax resistance in Acute Myeloid Leukemia and reveals targetable vulnerabilities
Abstract Despite the clinical success of the BCL2 inhibitor venetoclax in acute myeloid leukemia (AML), treatment resistance frequently emer...
Switching between complement inhibitors in patients with PNH: A real-world analysis of strategy, efficacy, and safety.
Abstract Complement inhibition (CI) for paroxysmal nocturnal hemoglobinuria (PNH) has transformed patient (pt) care. In 2025, 3 C5 inhibitor...
Predictive value of red cell distribution width for SF3B1 mutation status in myelodysplastic neoplasms
Abstract Background: yelodysplastic neoplasms (MDS) with SF3B1-mutations represent a distinct subtype associated with ring sideroblasts, pre...
Cerebral and peripheral microvascular function in sickle cell disease: Blood flow and oxygen extraction via diffuse correlation and Near-Infrared spectroscopy
Abstract Sickle cell disease (SCD) patients experience chronic anemia and vaso-occlusion leading to a lack of oxygen delivery to tissues. Th...
Real-world outcomes of FLAG-ida salvage therapy in relapsed/refractory AML and validation of the salflage score: A pethema registry study
Abstract Background: Most adult patients with acute myeloid leukemia (AML) will relapse after achieving a first complete remission (CR) or s...
Real-world effectiveness of pegcetacoplan in paroxysmal nocturnal hemoglobinuria: A systematic review of clinical and patient-reported outcomes
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-rare, acquired, non-malignant hematological disorder that, if left...