Blood
Articles in this Issue
Targeting hyperfibrinolysis: A novel prevention and reversal strategy.
Abstract Activation of the fibrinolytic cascade is a common and difficult to manage cause of massive bleeding as in trauma, but available in...
Co-mapping clonal and transcriptional heterogeneity in somatic evolution via got-multi.
Abstract Somatic evolution drives cancer progression and therapy resistance. Underlying phenotypic progressions is the development of marked...
Treatment disparities in acute leukemia among patients with HIV: A nationwide analysis
Abstract Treatment Disparities in Acute Leukemia Among Patients With HIV: A Nationwide Analysis Background Leukemia and HIV individually inv...
PU.1: C/EBPα ratio-directed reprogramming converts B-ALL cells into stable M1 macrophages for scalable cancer immunotherapy
Abstract Macrophages exhibit remarkable functional plasticity, making them a promising therapeutic tool against infections, cancers, and tis...
Evaluating a doctor-in-the-loop AI-agent for multiple myeloma chart reviews
Abstract Background: Real-world data (RWD) plays an increasingly important role in healthcare. Leveraging derived variables, such as lines-o...
CDK7 enables adaptive gene transcription required by stromal cells to support distinct T-cell lymphoma phenotypes and represents a novel microenvironment-directed therapeutic target
Abstract Over 75% of PTCL-NOS patients fail to achieve long-term control with current therapies, highlighting the need for novel therapeutic...
Retrospective evaluation of the G8 score in CLL patients treated with targeted therapies: A single-center experience
Abstract Introduction: The evaluation of fitness status is a key factor in determining treatment strategies for Chronic Lymphocytic Leukemia...
Treatment free remission after asciminib (ABL001) based therapy in chronic Phase chronic myeloid leukemia (CP-CML) patients who relapsed after a prior attempt at TKI discontinuation-h jean khoury cure CML consortium study HJKC3-0003
Abstract Background: In a proportion of patients with chronic phase CML who achieve a sustained deep molecular remission (DMR), treatment di...
CAR-T cells manufactured after multiple myeloma triplet or quadruplet induction therapy have reduced functionality and an altered composition
Abstract Introduction: Multiple myeloma (MM) is an incurable plasma cell malignancy with increasing incidence in the United States. The appr...
Recreational use of nitrous oxide resulting in severe B12 deficiency, pancytopenia and hemolytic anemia
Abstract Introduction: B12 deficiency is often seen in pernicious anemia, gastric surgeries, and strict vegetarian/vegan, but there are an i...
Outcomes for Medicare recipients with multiple myeloma: A national retrospective trend analysis from 2015 to 2022
Abstract Introduction: Despite global decreases in overall cancer incidence, the incidence of multiple myeloma (MM) continues to increase at...
Low CMV and EBV infections in the era of letermovir with post-transplantation cyclophosphamide combined with tacrolimus and low-dose post engraftment ATG as gvhd prophylaxis.
Abstract Background Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) is the standard curative therapy for high-risk hematologi...
Prognostic factors and therapeutic outcomes in neurolymphomatosis: A 22-year cohort study from Mayo Clinic
Abstract Background Neurolymphomatosis (NL) is a rare and frequently underrecognized manifestation of lymphoma, characte...
Real-world rates of tyrosine kinase inhibitor prescription approval, fill, and adherence and associated factors in a national sample of patients with chronic myeloid leukemia
Abstract Background: Oral tyrosine kinase inhibitors (TKIs) have transformed chronic myeloid leukemia (CML) into a manageable disease, enabl...
Racial disparities in mycosis fungoides - from self-reported race to genetic ancestry analysis
Abstract Introduction: Racial disparities in mycosis fungoides (MF) and Sezary syndrome (SS) are well-documented, with self-identified Black...
Equalizing access to chimeric antigen receptor (CAR) T-cell therapies for myeloma patients
Abstract Introduction: Chimeric antigen receptor (CAR) T-cell therapies targeting B-cell maturation antigen (BCMA) have resulted in improved...
Trial in progress: Phase II Study of (early) combination salvage therapy with venetoclax and intensified decitabine in relapsed/refractory AML (VenSwitch)
Abstract Background and Significance Acute Myeloid Leukemia (AML) in the refractory or relapsed setting (r/r) has an unfavorable prognosis....
BT1: A CD84-targeting T-cell engager for selective eradication of leukemic stem cells in Acute Myeloid Leukemia
Abstract Introduction: Acute myeloid leukemia (AML) is sustained by a subpopulation of leukemic stem cells (LSCs) that are resistant to conve...
Dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-EPOCH) yields durable remissions and survival in adults with newly diagnosed acute lymphoblastic leukemia/lymphoma (ALL): Long-term follow-up of a prospective trial
Abstract BACKGROUND Treatment for adult ALL historically introduces toxicity and complexity that can be prohibitive for some patients (pts)....
Cost analysis compared with efficacy shows iron dextran surpassing other intravenous iron formulations in children: A tertiary children's hospital experience
Abstract Introduction Intravenous iron (IVI) therapy utilization for treatment of iron deficiency in children has increa...
Comparable survival with transplant-free approach versus autologous stem cell transplantation in adult relapsed/refractory classic Hodgkin lymphoma achieving complete remission
Abstract Introduction While high-dose therapy with autologous stem cell transplantation (HDT/ASCT) following salvage therapy remains the cur...
Outcomes of hypomethylating agent failure in patients with myelodysplastic syndromes
Abstract Background: Hypomethylating agents (HMA) are the current standard-of-care for patients with myelodysplastic syndromes (MDS). Though...
Consideration of genomic determinants improves the diagnostic accuracy of oligomonocytic chronic myelomonocytic leukemia
Abstract Recent updates to the monocyte count thresholds for diagnosing chronic myelomonocytic leukemia (CMML) have recognized oligomonocyti...
A retrospective multi-center review of the safety and efficacy of bispecific T-cell engagers in the management of post-transplant lymphoproliferative disorder – the bite PTLD study
Abstract Post-transplant lymphoproliferative disorder (PTLD) is a serious complication of organ transplant. Therapies include reduction of i...
Hypercoagulability in clonal hematopoiesis: A hidden contributor to thrombosis in the elderly
Abstract Introduction: Clonal hematopoiesis (CH) is characterized by the expansion of hematopoietic cells bearing somati...