Blood
Articles in this Issue
Thalidomide in beta-thalassemia – a systematic review and meta-analysis
Abstract Introduction. Beta-thalassemia, an inherited hemoglobinopathy, affects approximately 18 people per 100,000 worldwide. Severe cases...
Shorespan-017: Phase 3 extension study for safety of bomedemstat in participants with essential thrombocythemia who received bomedemstat from a prior clinical study
Abstract Introduction: Myeloproliferative neoplasms, such as essential thrombocythemia and myelofibrosis, cause vascular events and systemic...
TP53, EZH2, or RUNX1 mutations predict poor outcomes in ELN 2022 adverse risk group of adult AML patients undergoing allo-HSCT
Abstract Background: Although European Leukemia Net (ELN) 2022 risk classification is a standard prognostic model in adult acute myeloid leu...
Trends and disparities in coagulation defect-related mortality in older adults in the United States from 1999 to 2023: A CDC wonder database analysis
Abstract Introduction: Coagulation defects are a spectrum of disorders that impair the body's ability to regulate blood clotting and are pre...
Accelerating practical solutions for bispecific antibody consideration for multiple myeloma in the community setting: Findings from an implementation science initiative
Abstract BACKGROUND: Emerging therapeutic classes continue to answer the call for novel therapies for multiple myeloma (MM), particularly fo...
Examining diet quality and patient-reported outcomes in myeloproliferative neoplasms: Results from a cross-sectional observational study
Abstract INTRODUCTION: Patients with myeloproliferative neoplasms (MPNs) experience substantial symptom burden, elevated cardiovascular dise...
Who participates in myeloma trials? clinical and geographic predictors of access and outcomes in British Columbia, Canada.
Abstract Introduction: Clinical trials (CTs) are essential for advancing evidence-based treatment in multiple myeloma (MM), offering patient...
Measuring patient preference information for blood cancer treatments and outcomes: A systematic review and meta-analysis
Abstract Background: Patient preference studies capture the value patients place on treatments, outcomes, and care delivery. Patient prefere...
Consolidation (Cons) and maintenance (Maint) approaches in primary central nervous system lymphoma (PCNSL) after high-dose methotrexate induction in transplant-ineligible patients
Abstract Background PCNSL is a rare, aggressive non-Hodgkin lymphoma that primarily affects older adults. Standard treatment involves high-do...
Humanized PDX models reveal Lymphoma–Host interactions and enhanced T-cell therapies via epigenetic modulation
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is a biologically and molecularly heterogeneous malignancy with variable therapeu...
Both platelet factor 4 (PF4) and b2-glycoprotein I (b2GPI) bind to von Willebrand factor (VWF) and inhibit ADAMTS13 cleavage: Mechanistic and clinical implications in thrombotic thrombocytopenic purpura (TTP)
Abstract Background: PF4 is a platelet-specific chemokine released in large amounts from activated platelets that binds to the A2 domain of...
Daratumumab versus lenalidomide as maintenance therapy in newly diagnosed multiple myeloma – final results from a randomized investigator-initiated trial
Abstract Introduction Lenalidomide (len) is the standard maintenance therapy in multiple myeloma (MM) due to its proven...
Theta oscillation attenuation as an electroencephalogram biomarker for intracranial infections in hematologic malignancies
Abstract Background: Patients with hematologic malignancies frequently experience immune suppression that predisposes them to intracranial i...
Reduction of infections with intravenous immunoglobulin in chronic lymphocytic leukemia: A single-center retrospective analysis
Abstract Introduction: Hypogammaglobulinemia is common in patients with chronic lymphocytic leukemia (CLL). Per consensu...
Long-term outcomes of intensive immunosuppressive therapy combined with eltrombopag in patients with severe aplastic anemia
Abstract Background：For severe aplastic anemia (SAA)patients who are ineligible for allogeneic hematopoietic stem cell transplantation (HSC...
Developing expert consensus for specialist e-consult response: A delphi study to inform graduate medical education
Abstract Introduction To meet the demands of a growing number of specialty referrals, outpatient electronic consultations (e-consults) have...
Cytoplasmic localization of qki mediates therapeutic resistance and immune evasion
Abstract The combination of the BCL2 inhibitor venetoclax with the hypomethylating agent 5-azacytidine has revolutionized AML treatment in o...
Inadequate social support and household material hardship among children with pediatric acute lymphoblastic leukemia: A report from the Children's oncology group Trial AALL1731
Abstract Introduction: Parents of children with cancer living in poverty experience higher rates of psychological distress during childhood...
Efficacy and Safety of Zanubrutinib Combined with Rituximab and High-Dose Methotrexate in the Treatment of Central Nervous System Diffuse Large B-Cell Lymphoma
Abstract Background: Central nervous system diffuse large B-cell lymphoma (CNS DLBCL) is a relatively rare extranodal non-Hodgkin lymphoma w...
Acidosis and hypoxia cooperatively impair immune cell infiltration in a microengineered tumor microenvironment
Abstract Introduction Recent advances in cancer immunotherapies, particularly chimeric antigen receptor (CAR) T and natural killer (NK) cell...
Phase 1b safety run-in study followed by Phase 2 study of ficlatuzumab, azacitidine and venetoclax in untreated Acute Myeloid Leukemia patients aged ≥ 60 years old
Abstract Background: Hepatocyte growth factor (HGF) is an autocrine produced cytokine that has been identified to be released by acute myeloi...
Autologous stem cell transplantation versus consolidation chemotherapy as post-remission treatment in newly diagnosed favorable and intermediate risk patients with AML: A comparative analysis of HOVON-SAKK-Nordic trials
Abstract Introduction High-dose chemotherapy followed by autologous stem cell transplantation (auto-HCT) or consolidatio...
The dynamic landscape of immune environment for MM patients receiving T cell redirectiing therapies
Abstract Background: Multiple myeloma (MM) is a major hematologic malignancy driven by clonal plasma cells in the bone marrow. BCMA-directed...
IL-1β-induced signaling modulates cytokine release and apoptosis in IDH1-mutant AML
Abstract Inflammatory signaling contributes to the progression of acute myeloid leukemia (AML) and impaired hematopoiesis, partly through NF...
Triple base-edited dual targeting CD70/33 CAR T cells to avoid cytokine-mediated resistance in Acute Myeloid Leukemia
Abstract Background: CAR-T cells have yet to demonstrate substantial efficacy for acute myeloid leukemia (AML) despite successes in lymphoid...