Blood
Articles in this Issue
Paroxysmal nocturnal hemoglobinuria in pediatric patients: A UK experience
Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder characterised by intravascular hemolysis, thrombosis and an associatio...
Mortality-related risk factors associated with continuous renal replacement therapy in critically ill patients with hematologic disorders: A retrospective cohort study
Abstract Background：Continuous renal replacement therapy (CRRT) is increasingly employed for critically-ill patients with hematologic disor...
Phase II trial of venetoclax in combination with azacitidine as maintenance therapy for high-risk acute leukemia following allogeneic stem cell transplantation
Abstract Background: Allogeneic stem cell transplantation (alloSCT) remains the only potentially curative therapy for patients with acute my...
In Vivo correction of the sickle cell disease mutation in hematopoietic stem cells using RNA gene writers
Abstract Tessera Therapeutics is pioneering a novel approach to in vivo genome editing that uses RNA Gene Writers and delivery of all RNA-ba...
Erythropoietin stimulates rapid egress of erythroid and lymphoid cells via the CXCR4–CXCL12 axis
Abstract Erythropoietin (EPO) is a principal regulator of erythropoiesis, however, its immediate effects on bone marrow (BM) are not fully r...
Impact of hepatitis b virus infection on long-term prognosis in B-cell lymphoma: A retrospective cohort study
Abstract Background: Hepatitis B virus (HBV) infection is a common comorbidity in patients with B-cell lymphoma (BCL), yet its impact on lon...
CD47 mediates oxygen-responsive activation of RBC eNOS during circulatory transit
Abstract BACKGROUND: Red blood cells (RBCs) contain active type 3 endothelial nitric oxide synthase (eNOS); however, the precise regulation...
Outcomes of outpatient chimeric antigen receptor T-cell therapy administration: A single center experience at an urban hospital
Abstract Introduction: Since initial approval in 2017, chimeric antigen receptor T-cell therapy (CAR-T) has transformed outcomes for hematol...
Infectious complications in elderly newly diagnosed acute myeloid leukemia patients treated with hypomethylating agents with or without venetoclax: Comparison with a historical control group treated with intensive chemotherapy
Abstract Introduction. The so called “less intensive” therapies, such as hypomethylating agents (HMA)±venetoclax (VEN), for acute myeloid le...
A first-in-human Phase 1 trial of LY4152199, a B-cell activation factor receptor (BAFF-R) T-cell engager bispecific antibody, in patients with previously treated B-cell malignancies (BAF_FRontier-1 Trial in Progress)
Abstract Background: B-cell activating factor receptor (BAFF-R) is essential to B-cell development and survival and is highly expressed acro...
A therapy-driven approach to designing personalized pain care in sickle cell disease
Abstract Background: Chronic pain in Sickle Cell Disease (SCD) is not one-size-fits-all. It stems from a mix of biologic...
Day 7 mount sinai acute GVHD international consortium (MAGIC) algorithm probability predicts GVHD and non-GVHD-related non-relapse mortality in a contemporary cohort of allogeneic transplant patients
Abstract The Mount Sinai Acute GVHD International Consortium (MAGIC) developed and validated the MAGIC algorithm probability (MAP), which is...
A phase 2 trial of teclistamab plus daratumumab combination therapy for high-risk smoldering multiple myeloma: First pre-planned analysis (the REVIVE Study)
Abstract Introduction Recently, subcutaneous (SC) daratumumab monotherapy (compared to active monitoring) has been found to significantly lo...
A national cancer database study of survival trends in patients with classical Hodgkin lymphoma: Improved survival in the novel agent era
Abstract Introduction: Brentuximab vedotin (BV) was approved by the US FDA for relapsed/refractory (R/R) classical Hodgkin lymphoma (cHL) in...
Functional genomic screens identify positive and negative regulators of venetoclax resistance
Abstract Multiple myeloma (MM) is a heterogeneous plasma cell malignancy characterized by variable responses to standard therapies. During B...
Heparin-induced thrombocytopenia after percutaneous coronary intervention complicated by hemothorax and pulmonary thromboembolism: The scylla and charybdis of hematology
Abstract Introduction: Heparin-induced thrombocytopenia (HIT) is an immune-mediated reaction to heparin caused by antibodies directed agains...
Interim analysis of safety and efficacy in a Phase 2 study of MB-105, a CD5.CAR T therapy for patients with relapsed/refractory T cell lymphoma
Abstract Introduction: There are few effective treatments for patients (pts) with relapsed/refractory T-cell lymphoma (R...
Efficacy and safety of the antithrombin siRNA fitusiran as prophylaxis in haemophilia a and B: A systematic review and meta-analysis
Abstract Introduction: The management of bleeding in individuals with Haemophilia A and B has proven to be challenging. Conventional treatme...
Deep learning architecture, EfficientNetB1, excels in accurate diagnosis and prognosis of acute lymphoblastic leukemia through intelligent computer vision
Abstract Background: Acute lymphoblastic leukemia (ALL) represents a clonal expansion of immature lymphoid progenitors a...
Comorbidities and outcomes in patients with Acute Myeloid Leukemia with and without type II diabetes mellitus admitted for chemotherapy: A national inpatient sample analysis
Abstract Introduction- Acute myeloid leukemia (AML) often has co-existing type II diabetes mellitus (TIIDM), and poor gl...
Predictors of 30-day readmission following CART cell therapy: A single-center experience
Abstract Background: Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the treatment of relapsed and refr...
Spiritual wellness and quality-of-life in adult patients with newly diagnosed acute leukemia receiving initial therapy: Patient-reported outcomes (PROs) from a prospective observational study
Abstract Introduction Acute leukemia (AL) is a life-threatening hematologic malignancy that often necessitates urgent hospitalization and ra...
Study on the potential of limosilactobacillus fermentum laf - 09 of gastric origin in humans to prevent nsaids - induced gastric ulcers and acute gastric hemorrhage
Abstract Background : Peptic ulcer disease ( PUD ) is mainly caused by Helicobacter pylori infection and the use of non-steroidal anti-infla...
Assessing the influence of live and online enduring CME activities presented at the 66th ASH annual meeting on hematology/oncology specialists using pre-/post-education evaluations
Abstract Background: With the rapid advancements in translational and clinical research spanning classical and malignant hematology, many he...
Isatuximab subcutaneous by on-body injector in Relapsed/Refractory multiple myeloma in the Phase 3 iraklia study: Effect of body weight on pharmacokinetics and clinical outcome
Abstract Introduction: IRAKLIA is an international, open-label, non-inferiority (NI) trial (NCT05405166) investigating isatuximab (Isa) subc...