Blood
Articles in this Issue
Detection of iron deficiency anaemia in cirrhosis: Diagnostic utility of ferritin and MCV in a large UK primary care cohort
Abstract Background: Iron deficiency anaemia (IDA) is common yet often under-evaluated in cirrhosis, where chronic inflammation complicates...
Comprehensive DNA/RNA-based targeted sequencing for molecular karyotyping and clonality assessment in newly diagnosed multiple myeloma patients
Abstract Multiple myeloma (MM) is a genetically heterogeneous malignancy marked by complex clonal dynamics and a range of cytogenetic altera...
Effectiveness of second-line therapies following upfront daratumumab plus bortezomib, cyclophosphamide and dexamethasone: A new benchmark
Abstract Background Daratumumab plus bortezomib, cyclophosphamide and dexamethasone (D-VCd) is the only FDA-approved treatment regimen for n...
Quantitative morphological parameters of bone marrow plasma cells are predictive of outcomes in plasma cell dyscrasias
Abstract Introduction: Morphologic evaluation of bone marrow cells remains a cornerstone of the MICM (morphology-immunophenotyping-cytogenet...
First-line romiplostim combined with immunosuppressive therapy for severe aplastic anemia: A prospective, single-arm, Phase II study
Abstract Background Incorporating thrombopoietin receptor agonists (TPO-RAs) into standard immunosuppressive therapy (IST) has significantly...
Cellular senescence associated with aging and chemotherapy exposure primes bone marrow for immune dysfunction and myeloma persistence
Abstract Age-related decline in immune function increases susceptibility to hematologic malignancies. Although bone marrow (BM) orchestrates...
Applying computational modelling to a high-risk multiple myeloma data set to create novel risk stratification groupings
Abstract Introduction: Multiple Myeloma (MM) is a heterogeneous disease making it difficult to accurately predict the di...
Ofirnoflast suppresses heme-induced inflammation, representing a novel therapeutic strategy for hemolytic anemias
Abstract Background: Hemolytic anemias, such as sickle cell disease, are characterized by accelerated red blood cell destruction, which resu...
Efficacy and safety of bmetl regimen (Orelabrutinib plus Semustine, Temozolomide and Lenalidomide) with subsequent maintenance treatment in elderly/frail patients with CNSL
Abstract Introduction: Central nervous system lymphoma (CNSL) is an aggressive lymphoma (Radke J et al. Nat Commun. 2022), including primary...
Epigenetic basis of MDS/MPN overlap syndrome with compound loss of Kmt2c and Dnmt3a
Abstract Monosomy 7, or loss of 7q (-7/del(7q)), is one the most common chromosomal anomalies in myelodysplastic syndromes (MDS, ~10% of pat...
First interim analysis of venetoclax real-world observational study on newly-diagnosed AML patients in Italy (VERO): Focus on patient and diseases characteristics and quality of life at baseline
Abstract Introduction The Venetoclax Real-World Observational study on effectiveness and treatment management in patients with Newly-Diagnos...
Early discharge patients have non-inferior outcomes following inpatient CAR-T infusion
Abstract Administration of chimeric antigen receptor (CAR)–modified T-cell therapy has evolved to become a mainstay treatment in patient wit...
Prospective monitoring of 591 cancer patients with clonal hematopoiesis detected in daily practice
Abstract Introduction Clonal hematopoiesis (CH) is enriched in patients with cancer and has been linked to adverse outcomes. Although often...
Pediatric cancer risk factors: A review of literature
Abstract Introduction According to Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute (NCI), the in...
CAR T cell therapy referral patterns and characteristics of patients with relapsed or refractory (R/R) large B cell lymphoma (LBCL) in the United States
Abstract Introduction: CAR T cell therapies are a pivotal advancement in the treatment of R/R LBCL that offer the potential for long-lasting...
Recombinant von willebrand factor for perioperative management of bleeding in pediatric patients with severe von willebrand disease: Interim results from a phase 3 multicenter study and a phase 3b continuation study
Abstract Introduction: Von Willebrand disease (VWD) is the most common bleeding disorder in children. Recombinant von Willebrand factor (rVW...
Integrated genomic and immunophenotypic profiling of histiocytic disorders reveals therapeutic implications of differential BCL2 expression
Abstract Background Histiocytic disorders, including Langerhans Cell Histiocytosis (LCH), Erdheim-Chester Disease (ECD), and Rosai-Dorfman D...
A randomized study of conventional chemotherapy +/- uproleselan in older adults with Acute Myeloid Leukemia eceiving intensive induction chemotherapy (Alliance A041701)
Abstract Background. Uproleselan (GMI-1271) is an antagonist of E-selectin, an adhesion molecule expressed on endothelial cells in the vascul...
Treatment intensity and region of diagnosis affect survival in primary CNS lymphoma in England: A national cohort study from the uncover project.
Abstract Introduction. The IELSG32 study established MATRix as a standard remission induction regimen for patients ≤70 y...
Pilot study: Assessing allostatic load score and outcomes in Acute Myeloid Leukemia patients in North Carolina
Abstract Background: Allostatic load (AL) represents the cumulative systemic stress burden on an individual's body, involving neuroendocrine...
Chidamide in combination with azacitidine, mitoxantrone liposomes, and prednisone (CAMP regimen) for treatment-naïve TFH-derived peripheral T-cell lymphoma
Abstract Objective: Peripheral T-cell lymphoma (PTCL) is a rare but challenging malignancy, in which the TFH (T follicular helper)-derived P...
The synonymous IDH1 p.Gly105Gly (rs11554137) variant associates with AML post-transplant relapse via aberrant signal transduction pathways
Abstract Background Missense mutations in IDH1 are well-established therapeutic targets in acute myeloid leukemia (AML). In contrast, the sy...
Preliminary efficacy and safety of golidocitinib in relapsed/refractory T cell and NK cell large granular lymphocyte leukemia
Abstract Backgroud: Large granular lymphocyte leukemia (LGLL) is a rare and incurable hematologic malignancy with minimal therapeutic advance...
Efficacy and safety of FLAG and CLAG regimens (Replacing Cyclophosphamide) in conditioning for allogeneic hematopoietic stem cell transplantation in relapsed/refractory malignant hematologic diseases
Abstract Background: The F (fludarabine) LAG (cytarabine+granulocyte colony-stimulating factor, G-CSF) and C (cladribine) LAG regimens have...
Scalable production and anti-tumor efficacy of iPSC-derived immortalized anti-CD19 CAR macrophages
Abstract Chimeric antigen receptor (CAR) -T cell therapy has shown remarkable efficacy in patients with relapsed or refractory mature B cell...