Blood
Articles in this Issue
Thromboembolic and cardiovascular events after CAR-T cell therapy in multiple myeloma: A propensity-matched real-world analysis
Abstract Background Chimeric antigen receptor T-cell (CAR-T) therapy has transformed outcomes in relapsed/refractory multiple myeloma (MM) b...
Dark genome interrogation identifies novel antigens in Acute Myeloid Leukemia – developing an off-the-shelf vaccine from machine learning to clinic
Abstract Introduction Durable responses remain rare in patients with Acute Myeloid Leukemia (AML) who are ineligible for intensive chemother...
Ruxolitinib and interferon alfa induce superior rates of complete peripheral blood count remission compared to anagrelide in hydroxyurea-exposed essential thrombocythemia
Abstract Introduction: Essential thrombocythemia is a myeloproliferative neoplasm characterized by elevated platelets and a predilection for...
Predictors of clinically relevant bleeding during extended anticoagulation for cancer-associated venous thromboembolism, including by cancer site: Post-hoc analysis of the API-CAT randomised trial
Abstract Background : As shown by the API-CAT study, extended anticoagulation with reduced-dose apixaban is non-inferior to full-dose apixab...
Trial in progress: Safety and feasibility of a venetoclax-augmented treosulfan-based reduced intensity conditioning before allogeneic stem cell transplantation in AML, MDS/AML and higher risk MDS (VeStAL)
Abstract Background and Significance For many patients with AML and higher risk MDS, allogeneic hematopoietic stem cell translplantation (HS...
Funcional cure in advanced follicular lymphoma: Real word experience from two academic centers from Argentina
Abstract Introduction: Follicular lymphoma (FL) is the most common indolent B-cell non-Hodgkin lymphoma. In most cases, it presents as asymp...
Empowering families through conversational design: A chatbot for sickle cell care
Abstract Background Children's Healthcare of Atlanta (CHOA) provides care for over 2000 pediatric sickle cell disease (SCD) patients annuall...
High mortality rate of warm autoimmune haemolytic anaemia: Real-world incidence and outcomes from a comprehensive regional audit
Abstract Background: Warm autoimmune haemolytic anaemia (wAIHA) is rare but associated with significant mortality, morbidity, and treatment-...
Myeloid sarcoma as a pancreatic cancer mimic: Refining the clinical differential of pancreatic masses
Abstract Introduction Myeloid sarcoma (MS) is a rare extramedullary tumor composed of immature granulocytes or monocytes and is an uncommon...
A quality improvement project to optimize VTE prophylaxis in surgical patients
Abstract Introduction Venous thromboembolism (VTE) is a leading cause of preventable morbidity and mortality among hospitalized surgical pat...
Efficacy of mitapivat in patients with transfusion-dependent alpha-thalassemia: Subgroup analysis from the ENERGIZE-T trial
Abstract Introduction: Thalassemia is caused by an imbalance of globin chains within red blood cells (RBCs) creating an excess of α-globins...
Filter coagulation related risk factors associated with continuous renal replacement therapy in critically ill patients with hematologic disorders: A retrospective cohort study
Abstract Background: For hematological critical illness with acute kidney injury, citrate anticoagulation and Continuous Venous-venous Hemod...
Semantic features associated with outcome in patients treated with CAR-T therapy
Abstract BACKGROUND: Recent development in chimeric antigen receptor (CAR) T-cell therapy has shown tremendous promise in providing a durabl...
Time to transfer – the clock is ticking: A quality improvement project
Abstract Background: Aggressive hematologic malignancies such as acute myeloid leukemia and aggressive lymphomas can be challenging to diagn...
Survival and response rates of histone deacetylase inhibitors in peripheral T-cell lymphoma: A comprehensive systematic review and meta-analysis of 67 studies.
Abstract Introduction: Peripheral T-cell lymphomas (PTCL) account for 5-15% of non-Hodgkin lymphomas. It has high relapses and unfavorable p...
Racial and ethnic disparities in the risk of second primary malignancies among diffuse large B-cell lymphoma survivors in the United States
Abstract Background: Previous studies have shown an increased risk of second primary malignancies (SPMs) among diffuse large B-cell lymphoma...
Unwinding the genomic threads of monoclonal gammopathy of renal significance through ultra-low pass whole genome sequencing
Abstract Introduction The monoclonal gammopathies of renal significance (MGRS) are defined by the presence of a nephrotoxic monoclonal protei...
Survival disparities by race and income among adolescents and young adults with acute lymphoblastic leukemia
Abstract Background: Since 2012, the adoption of pediatric-inspired regimens, the integration of tyrosine kinase inhibit...
Characterizing return-to-school after pain-related hospitalizations and hospital re-admission risk in pediatric sickle cell disease
Abstract Introduction: Pain is the primary cause of inpatient admissions in sickle cell disease (SCD), and re-admission to the hospital foll...
METTL14 overexpression identifies a biologically aggressive subgroup and correlates with adverse clinical outcomes in multiple myeloma
Abstract Background N⁶-methyladenosine (m⁶A) is the most prevalent internal modification of eukaryotic mRNA and plays a central role in post...
Cardiac complete response in AL amyloidosis: Phenotypic characteristics, functional recovery, and survival outcomes of 63 patients
Abstract Cardiac involvement in AL amyloidosis significantly impacts both short and long-term survival. Achieving cardiac complete response...
Evolution of t(11;14) biology in multiple myeloma and it's role on outcomes to venetoclax treatment
Abstract Introduction: The chromosomal translocation t(11;14)(q13;q32) is found in nearly 20% of multiple myeloma (MM) patients. MIDAS trial...
Automated AI classification in clinical flow cytometry: Transforming B-cell lymphoma diagnostics
Abstract Introduction: Flow cytometry (FC) holds a pivotal role in hematological diagnostics. Although capable of turn-a...
TCR-T cells expressing a TCR recognizing the MPO propeptide-derived MPO132-140:HLA-a*02:01 specifically kill AML and spare healthy myeloid cells
Abstract Patients with AML/MDS have limited therapeutic options. While antigen-specific T cell therapies (e.g. CAR-T) have shown curative po...
Exploiting HLA-e restricted T cell receptors to develop universal cellular therapies for virus-associated malignancies
Abstract Adoptive T cell receptor-engineered therapies (TCR-Ts) enable targeted redirection of T cells to tumor antigens presented by human...