Blood
Articles in this Issue
Machine learning–based detection model for leukemia cells in peripheral blood smears using YOLOv11-large
Abstract Background: Identification of blood cell types is crucial for diagnosing and managing hematological diseases such as lymphoma and l...
N6-methyladenosine (m6A) RNA modification is required to final plasma cell differentiation
Abstract Plasma cells are highly specialized cells representing the end stage of B cell differentiation. They play an important role in humo...
An mRNA-based cytomegalovirus vaccine induces robust T-cell immune responses in cytomegalovirus-seropositive adults who have undergone allogeneic hematopoietic cell transplantation
Abstract Background: Cytomegalovirus (CMV) establishes lifelong latency and is an important risk factor for increased morbidity and mortalit...
Efficacy and safety of isa-vrd in elderly patients with or without frailty criteria: Pooled analysis of imroz and phase 1b studies in newly diagnosed multiple myeloma patients
Abstract Introduction: In the phase 3 IMROZ study (NCT03319667), isatuximab (Isa) given intravenously (IV) with bortezomib, lenalidomide and...
ENO1 promotes Acute Myeloid Leukemia progression through SCD1-mediated lipid metabolism reprogramming
Abstract Enhanced glycolysis and aberrant hyperactivation of glycolytic enzymes collectively contributes to tumor progression and chemoresis...
Lipid uptake via FATP2 enhances CAR-t therapy resistance in B-cell acute lymphoblastic leukemia
Abstract Chimeric Antigen Receptor T cell (CAR-T) therapy is highly effective for treating relapsed/refractory B-cell acute lymphoblastic le...
Repertoire of driver events in coding and non-coding regions identified by whole-genome sequencing of myeloid neoplasms
Abstract Introduction: During the past two decades, our knowledge about the molecular pathogenesis of myeloid neoplasms (MNs), including acu...
R2* MRI in evaluation of hepatic iron overload and its correlation with serum ferritin in transfusion-dependent beta-thalassemia
Abstract Introduction: For patients with transfusion-dependent thalassemia (TDT), regular blood transfusions are a double-edged sword. While...
Individualizing apheresis processing volumes using a predictive algorithm: Analysis of the CAR T-cell collection protocol utilized in ACIT001/EXC002, a phase lb/ll trial of decentralized production of CAR T-cells for treatment of relapsed/refractory aggressive NHL and ALL
Abstract Introduction: Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment landscape for relapsed/refractory (R/R)...
Sequential BCMA- and GPRC5D-targeted bispecific antibody therapy in multiple myeloma: Real-world outcomes and first report of dual bispecific antibody-refractory patients
Abstract Introduction: BCMA and GPRC5D bispecific antibodies (BsAbs) are indispensable therapies for relapsed/refractory multiple myeloma (R...
Prospective clinical validation of MAC-scoring as an affordable, real-time biomarker for HMA/venetoclax response in AML
Abstract The treatment of acute myeloid leukemia (AML) has been transformed by incorporating hypomethylating agents (HMA) like 5-Azacytidine...
MSC regulates the function of neutrophils through mitochondrial transmission to treat early pulmonary fibrosis
Abstract Mesenchymal stem cells (MSCs) are a type of adult stem cells with immunomodulatory properties. Recently, due to their safety and ef...
Association of socioeconomic indicators with survival in chronic myeloid leukemia: A retrospective analysis
Abstract Background Tyrosine kinase inhibitors (TKIs) have improved outcomes of patients (pts) with chronic myeloid leukemia (CML). However,...
Measurable residual disease (MRD) assessment as an early end point oftreatment efficacy in acute myeloid leukemia (AML): A pethema studyof 2,623 patients (Pts) treated with intensive therapy
Abstract Background: Despite advances in treatment of AML pts considered fit for intensive therapy, significant unmet medical needs remain....
Long-term clinical outcomes from the smart start trial: Rituximab, lenalidomide and ibrutinib in patients with newly diagnosed large B-cell lymphoma
Abstract Background Approximately 30-40% of patients (pts) with diffuse large B-cell lymphoma (DLBCL) develop relapsed or refractory (r/r) di...
Etoposide + cytarabine + pegfilgrastim vs cyclophosphamide + granulocyte colony-stimulating factor for stem-cell mobilization in patients with multiple myeloma: A phase III trial
Abstract Background: For multiple myeloma (MM) autologous stem cell transplantation (auto-SCT) to be successful, adequat...
Salvage whole brain radiotherapy after methotrexate failure in primary cns lymphoma
Abstract Introduction: Primary CNS lymphoma (PCNSL) is a rare and aggressive subtype of mostly B-cell non-Hodgkin lymphoma. While high-dose m...
First-in-human phase I study of HCB101, a 3.5th-generation CD47-SIRPα fc fusion protein: Cytopenia-sparing safety, broad pharmacologic window, and low-dose clinical activity in relapsed/refractory non-Hodgkin lymphoma
Abstract Introduction: Non-Hodgkin lymphoma (NHL) comprises a heterogeneous group of lymphoproliferative malignancies arising from B, T, or n...
Incidence and risk factors for CNS relapse in adult ALL after allogeneic hematopoietic cell transplant
Abstract Introduction Relapse in the central nervous system (CNS) is a devastating outcome in acute lymphoblastic leukemia (ALL). Increasing...
primary breast lymphoma: A 10-year retrospective case series on clinical features, diagnostic imaging, and outcomes from a diverse population treated at mount sinai medical center in miami beach
Abstract Introduction Primary breast lymphoma (PBL) is a rare subtype of non-Hodgkin lymphoma (NHL), accounting for less...
Transfer and integration into a young adult clinic for sickle cell disease: Stay with me
Abstract Introduction: Near universal survival of children with sickle cell disease (SCD) into adulthood makes transition from pediatric to...
Humanized CD19 chimeric antigen receptor (CAR) T-cell therapy for high-risk and post-CAR relapse of B-cell acute lymphoblastic leukemia
Abstract Background CD19-directed chimeric antigen receptor T-cell (CART19) therapy has transformed the treatment landscape for relapsed/ref...
Multi-modal profiling and targeting of the tumor microenvironment in central nervous system lymphoma
Abstract Primary central nervous system lymphoma (PCNSL) is a highly aggressive B-cell lymphoma confined to the CNS and associated with a po...
Risk of hepatitis B virus reactivaton in HBsAg-negative, anti-hbc-positive patients receiving rituximab: A systematic review
Abstract Background Rituximab is an anti-CD20 monoclonal antibody widely used in the treatment of hematologic malignancies and autoimmune co...
Efficacy and safety of iptacopan in Chinese patients with paroxysmal nocturnal hemoglobinuria: A multicenter retrospective study
Abstract Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal disorder caused by PIGA mutations leading to deficiency of G...