Blood
Articles in this Issue
Pre-CAR next generation sequencing informs patient outcomes in children and young adults with B-acute lymphoblastic leukemia
Abstract Introduction Lower baseline disease burden associates with improved survival in children and young adults with B-cell acute lymphob...
High serum C3 complement levels were associated with poor prognosis of angioimmunoblastic T-cell lymphoma (AITL)
Abstract Background ： Angioimmunoblastic T-cell lymphoma (AITL), a distinct subtype of peripheral T-cell lymphoma (PTCL), presents with uni...
Modal CAR T cells: A synthetic cytokine circuit to overcome TGFβ-mediated immunosuppression in AML
Abstract Chimeric antigen receptor (CAR) T cells have shown clinical success in B and plasma cell derived hematologic malignancies, but dura...
High-throughput single-cell lipidomics reveals stage-specific phospholipid remodeling and ferroptosis-related signatures in the Evolution of plasma cell dyscrasia
Abstract Introduction: Multiple myeloma (MM) evolves through a well-defined clinical continuum from monoclonal gammopath...
Temperature volatility as a novel environmental trigger for immune thrombocytopenia: A retrospective case-control study
Abstract Introduction: Immune thrombocytopenia (ITP) is an acquired autoimmune disorder marked by immune-mediated platelet destruction. Alth...
Neutrophil-TLR9 is a therapeutic target for acute chest syndrome in sickle cell disease
Abstract Introduction: Acute chest syndrome (ACS), a severe form of acute lung injury, is a leading cause of morbidity and mortality in pati...
Post-treatment outcomes of TP53-mutant Mantle Cell Lymphoma patients treated with frontline zanubrutinib, obinutuzumab, and venetoclax (BOVen): Durable responses in patients who achieve complete remissions with undetectable MRD
Abstract Background: Mantle cell lymphoma (MCL) patients with TP53 mutations have poor outcomes with standard chemoimmunotherapy (Eskelund, B...
Initiation of ACE inhibitors or beta-blockers during frontline therapy for pediatric Acute Myeloid Leukemia and the impacts on cardiotoxicity incidence and survival outcomes: A target trial emulation
Abstract Background Anthracycline (ATC)-related cardiotoxicity is a well-recognized complication in pediatric acute myeloid leukemia (AML) a...
Comparative safety and efficacy of bendamustine versus fludarabine/cyclophosphamide prior to chimeric antigen receptor- T cell therapy: A systematic review and meta-analysis
Abstract Background: CAR T-cell therapy is a promising treatment for certain leukemias and lymphomas, particularly refractory non-Hodgkin ly...
Molecular predictors of anemia response to momelotinib in patients with myelofibrosis: Real-world outcomes from the momgemfin study.
Abstract In patients with myelofibrosis (MF), driver mutation status, presence of additional mutations (especially of high-molecular risk, H...
Increased teclistamab dosing interval improves T-cell diversity and reduces infection risk, while T-cell exhaustion remains minimal irrespective of schedule
Abstract Introduction: Bispecific antibodies are among the most effective treatments for relapsed/refractory multiple myeloma (RRMM), induci...
Treosulfan-based vs. busulfan-based conditioning for hematopoietic stem cell transplantation: A systematic review and meta-analysis.
Abstract Introduction Stem cell transplantation (SCT) continues to be a conventional treatment for many malignant and non-malignant hematolo...
National trends in sepsis-specific mortality among adults in the United States with multiple myeloma, a 24-year analysis
Abstract Background: Multiple myeloma (MM) is associated with severe immunosuppression, increasing the risk of infection...
Updated clinical outcomes of a Phase I/II trial of bispecific CD19/CD20-targeted CAR-T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma
Abstract Background: Non-Hodgkin lymphoma (NHL) is a common hematologic malignancy, and treatment options remain limited for patients with r...
Genome-wide CRISPR screening identifies CRL1 as a therapeutic target for restoring CD19 expression and improving immunotherapy efficacy in B-cell malignancies
Abstract Background: Antigen escape through CD19 downregulation is one of the key resistance mechanisms to CD19-targeted immunotherapies suc...
Pneumonia's impact on hospitalized Acute Myeloid Leukemia patient outcomes: A national inpatient sample study (Q4 2015 – 2022)
Abstract Introduction Acute Myeloid Leukemia (AML), a crowding disease of the bone marrow, is associated with multiple in-hospital infection...
Immune reconstitution following memory T-cell add back and prophylactic blinatumomab post TCRαβ/CD19-depleted haploidentical transplantation in pediatric patients with high-risk acute leukemia
Abstract TCRαβ depletion of haploidentical donor (haplo) grafts enables low rates of graft-versus-host disease (GVHD) but delays immune reco...
Burden and characteristics of infections in patients treated with bispecific antibodies and the impact of immunoglobulin replacement
Abstract Bispecific antibodies (BsAbs) targeting BCMA or GPRC5D have significantly improved outcomes in relapsed/refractory multiple myeloma...
Rising cardiovascular mortality among older adults with coexisting cancer and atrial fibrillation: A 25-year u.S. analysis (1999–2024).
Abstract Background: Cardiovascular diseases (CVDs) remain the leading cause of mortality in the United States. Older adults with comorbid c...
Significant improvement of bone marrow fibrosis in patients with chronic myeloproliferative neoplasms (CMPN) treated with ruxolitinib.
Abstract Ruxolitinib offers significant benefits for patients with myelofibrosis, particularly in enhancing survival rates and improving sym...
Disrupting a new NFkB-IL-6-JAK2-STAT cascade with novel NFkB inhibitors reduces primary myelofibrosis growth
Abstract Introduction: Primary myelofibrosis (PMF), a myeloproliferative neoplasm (MPN), features bone marrow fibrosis, splenomegaly, and ab...
Impact of voxelotor discontinuation on patients with sickle cell disease
Abstract Introduction: Hemolysis in sickle cell disease (SCD) contributes to complications such as anemia, leg ulcers, and kidney dysfunctio...
Mortality patterns and geographic variation in acquired hemophilia A among Medicare beneficiaries in the United States
Abstract Acquired hemophilia A (AHA) is a rare but life-threatening autoimmune bleeding disorder caused by autoantibodies against factor VII...
Determinants of renal survival in patients treated for monoclonal gammopathy of renal significance
Abstract Background: Monoclonal gammopathies of renal significance (MGRS) are a heterogeneous category of disorders characterized by renal dy...
Trends in acute TTP mortality amidst a shifting therapeutic landscape
Abstract Introduction: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal disorder with a mortality rate of 9...