Blood
Articles in this Issue
NRF2 transcriptionally activates DDIT4 to drive venetoclax resistance in AML
Abstract Background: Relapse and refractory disease remain major challenges in acute myeloid leukemia (AML), with venetoclax resistance sign...
Multicenter evaluation of guideline adherence for the timeliness of pain medication for acute sickle cell disease pain
Abstract Background Recurrent pain episodes are the leading cause of emergency department (ED) visits among patients wit...
Erythroid-specific, inducible CDAN1∆/∆ mouse model phenocopies congenital dyserythropoietic anemia type-la
Abstract Congenital dyserythropoietic anemias (CDAs) are a heterogenous group of inherited blood diseases, characterized by ineffective eryt...
Risk score and survival outcomes for multiple myeloma patients with disease refractory to BCMA CAR-T.
Abstract Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy targeting B-cell maturation antigen (BCMA) has revolutionized the tr...
ELN milestone-driven TKI switching improves deep molecular response rates in chronic myeloid leukemia
Abstract Background: Deep molecular response (DMR) is a prerequisite for successful treatment-free remission (TFR) in patients with chronic...
Sickle cell disease survival analysis at a large United States southern comprehensive sickle cell disease center: 1995 - 2022
Abstract Background: The University of Alabama at Birmingham (UAB) sickle cell disease (SCD) comprehensive center cares for most patients wi...
Artificial intelligence (AI) meets real-world disparities: A SEER-based study of Acute Myeloid Leukemia (AML) across race, ethnicity and gender
Abstract Background - As artificial intelligence (AI) is increasingly being integrated into hematology, concerns about fairness and equitabl...
CD90-targeted multiplex virus-like particles (MVPs) for concomitant In Vivo gene editing, transduction, and transcription factor delivery into HSCs
Abstract In vivo delivery strategies will substantially broaden the accessibility of Hematopoietic Stem Cell (HSC) gene therapy. However, cu...
Improved survival outcomes in angioimmunoblastic T-cell lymphoma linked to care at academic cancer centers: A national cancer database study.
Abstract Intro Angioimmunoblastic T cell lymphoma is a unique subtype of peripheral T cell lymphoma (PTCL), often associated with poor progn...
MAPK pathway-driven metabolic-inflammatory axis in AL amyloidosis
Abstract Introduction Systemic light chain (AL) amyloidosis is a clonal plasma cell disorder characterized by the deposition of misfolded im...
Evaluation of STAT6 and PD-L1 expression in Hodgkin/reed-sternberg (HRS)-like cells in Hodgkin lymphoma-like Richter transformation arising in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)
Abstract Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with classical Hodgkin lymphoma like Richter transformation (cHL-...
Combining axicabtagene ciloleucel (axi-cel) or relmacabtagene autoleucel (relma-cel) with HDT/ASCT in relapsed/refractory large B-cell lymphoma: A single-center experience
Abstract Background Three CD19-directed CAR T-cell therapies - axicabtagene ciloleucel (axi-cel), lisocabtagene maraleucel (liso-cel), and ti...
Targeting METTL3 disrupts oncogenic transcriptional programs and activates immune and apoptotic pathways in Acute Myeloid Leukemia
Abstract Introduction: Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy characterized by the clonal expansion of undiffe...
Multi-omic analysis of early minimal residual disease identifies functional and transcriptomic signatures of treatment resistance in pediatric B-cell acute lymphoblastic leukemia
Abstract Background Relapsed B-cell Acute Lymphoblastic Leukemia (B-ALL) remains a leading cause of cancer-related death...
The prognostic significance (or lack) of achieving marrow complete remission (mCR) with hypomethylating agent-based therapy in patients with myelodysplastic syndrome
Abstract Introduction: Marrow complete remission (mCR) in 2006 IWG criteria for MDS (Cheson B et al, Blood 2006) reflects achieving bone marr...
Impact of angiotensin-converting enzyme inhibitors (ACEis) or angiotensin II receptor blockers (ARBs) on kidney functions in allogeneic stem cell transplant patients receiving tacrolimus
Abstract Background Tacrolimus is a cornerstone for graft-versus-host disease prophylaxis (GVHD) after allogeneic hemato...
MaaT013 for ruxolitinib-refractory acute graft-versus-host disease with gastrointestinal involvement: Results from the ARES phase III trial
Abstract Introduction Refractory acute graft-versus-host disease (aGvHD) is a significant cause of mortality following allogeneic hematopoie...
A phase I study of the T-cell receptor-like antibody Hu8F4 in pts with advanced myeloid neoplasms
Abstract Background: Allogeneic (allo) stem cell transplantation (SCT) has been associated with improvement in long term outcomes in patient...
SNAI2 orchestrates a hypo-oxidative mitochondrial phenotype with elevated FAO dependence in acute myeloid leukemia
Abstract Introduction Acute myeloid leukemia (AML) is a heterogeneous malignancy with poor long-term survival despite intensive therapeutic r...
Secondary HLH: A complication of anaplasmosis infection
Abstract Introduction: Hemophagocytic lymphohistiocytosis (HLH) is an inflammatory condition. More specifically, there is an improper cytoto...
Belantamab mafodotin, nirogacestat, and pomalidomide in patients with relapsed/refractory multiple myeloma
Abstract Background B-cell maturation antigen (BCMA) directed therapies have demonstrated high efficacy in multiple myeloma (MM). While BCMA...
Detection of intratumoral microorganisms in DLBCL impacts on CART-cell outcomes
Abstract Introduction: In lymphoma, a non-disrupted gut microbiome has been associated with clinical response to CD19 CAR T (Smith et al., N...
Real-world outcomes of PK/PD-guided individualized emicizumab dose reduction in Chinese pediatric patients with hemophilia A: A prospective observational study
Abstract Background Emicizumab has markedly improved bleed prevention in hemophilia A, but its high cost remains a challenge, especially in...
A mutational grouping involving SRSF2, TET2, ASXL1, RUNX1, and STAG2 identifies patients with lower-risk myelodysplastic syndrome who benefit from higher-risk treatment strategies
Abstract Background: Myelodysplastic syndrome (MDS) is risk-stratified according to cytopenias, bone marrow blast percentage, and chromosoma...
Evaluating the impact of language on health care utilization outcomes in paitents with diffuse large B-cell lymphoma at a large safety-net hospital
Abstract Introduction: In the United States 25 million people have limited English proficiency. Individuals with limited English proficiency...