Blood
Articles in this Issue
Systematic review of non-icans neurological toxicities associated with BCMA and GPRC5D-directed CAR-T cell therapy in plasma cell dyscrasia
Abstract Introduction CAR T-cell therapy targeting BCMA and GPRC5D has demonstrated remarkable efficacy in relapsed/refr...
Novel In Vivo CAR platform for autoimmune disease therapy
Abstract Background: Autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS)...
Chidamide in combination with brentuximab vedotin for CD30+ peripheral T-cell lymphoma in patients ineligible for chemotherapy: a prospective phase II study
Abstract Background: The prognosis for patients with peripheral T-cell lymphoma (PTCL) remains extremely poor, posing significant challenges...
Impact of pre-existing central nervous system conditions and cognitive impairments on toxicity and outcomes after BCMA-directed CAR-T cell therapy
Abstract Background: Idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel) are BCMA-directed CAR-T...
Safety and effectiveness of brentuximab vedotin in patients with CD30- positive B-cell lymphoma: A multicenter, prospective, observational, real-world BRAVE study in China
Abstract Introduction: Brentuximab vedotin (BV), an anti-CD30 antibody-drug conjugate, has demonstrated effectiveness in CD30-positive lymph...
A phase 1/2, first-in-human, multicenter, open-label trial evaluating the safety, tolerability, and antileukemic activity of Debio 1562M in patients with recurrent refractory acute myeloid leukemia (AML)
Abstract Background and Significance: Acute Myeloid Leukemia (AML) is the most common adult acute leukemia and is an aggressive hematologic...
Restraint of TGF-β signaling by SMAD7 is necessary for the maturation of hematopoietic stem cells in the mouse embryo
Abstract Hematopoietic stem and progenitor cells (HSPCs) in the mouse embryo arise from a subset of arterial hemogenic endothelial cells whi...
Barriers to continuity of care and adult practice retention among adolescents and young adults with sickle cell disease
Abstract Introduction For adolescents and young adults (AYA) with sickle cell disease (SCD), successful pediatric to adult care transition i...
Inflammatory and metabolic gene signatures predict overall survival and response to venetoclax-based therapy in TP53 mutant AML
Abstract Introduction Acute myeloid leukemia (AML) with mutations in TP53 (TP53-Mut AML) is a high-risk disease with a dismal prognosis. How...
Luspatercept in patients with hematological diseases who have delayed erythroid recovery after allogeneic hematopoietic stem cell transplantation.
Abstract Introduction Delayed erythroid recovery after hematopoietic stem cell transplantation (HSCT) is a common and concerning complicatio...
Soluble immune modulators in the bone marrow microenvironment predict long-term survival in pediatric de novo AML: An olink-based proteomic and transcriptomic study
Abstract Background The bone marrow (BM) microenvironment plays a critical role in acute myeloid leukemia (AML) by shaping immune surveillan...
TP53 mutation promotes diffuse large B-cell lymphoma progression via mediating lactylation of ATP5E at Lys44
Abstract Lactate has recently been shown to play an important role in remodeling the tumor microenvironment and regulating energy metabolism...
Bortezomib-bendamustine-melphalan or high-dose melphalan in autologous hematopoietic stem cell transplantation for previously transplanted relapsed multiple myeloma – a single center retrospective cohort study
Abstract Introduction Despite the introduction of numerous novel agents, high-dose melphalan (HDM) followed by autologous hematopoietic stem...
Risk factors and prevalence of monoclonal gammopathy of undetermined significance (MGUS) by duffy genotype
Abstract Introduction: There is a 3x higher prevalence of MGUS in people identifying as Black. However, race is a social construct making th...
Autonomous BCR signaling and the CARD11 L251P mutation as alternative oncogenic drivers induce identical gene expression profiles in genetically engineered ABC-DLBCL models
Abstract Diffuse large B-cell lymphoma of activated B-cell type (ABC-DLBCL) is characterized by constitutive NF-kB activation through activa...
Liver-targeted delivery of bioengineered induced tregs via nanoparticles prevents and treats acute gvhd
Abstract Induced regulatory T cell (iTregs) therapy holds promise for graft-versus-host disease (GvHD), but clinical translation has been li...
Impact of slim-CRAB criteria on treatment initiation in newly diagnosed multiple myeloma in the veteran health administration
Abstract Introduction In 2014, the International Myeloma Working Group (IMWG) modified the diagnostic criteria for active multiple myeloma (...
Prognostic analysis of salvage allogeneic HCT in acute leukemia patients relapsing after autologous HCT: a study from the acute leukemia working party of the EBMT
Abstract Background While autologous hematopoietic cell transplantation (auto-HCT) is a feasible post-remission strategy for patients with a...
AKATSUKI third interim analysis: Safety of emicizumab during and after immune tolerance induction implementation
Abstract Background: Immune tolerance induction (ITI) therapy is recommended to eradicate factor (F)VIII inhibitors in people with hemophili...
Mortality associated with warm autoimmune hemolytic anemia among Medicare beneficiaries
Abstract INTRODUCTION: Warm autoimmune hemolytic anemia (wAIHA) is a rare, autoimmune-mediated hematologic disorder associated with signific...
Exploring molecular heterogeneity and clonal evolution in chronic myelomonocytic leukemia via single-cell transcriptome sequencing
Abstract Background: Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell disorder that combines clinical and biologic...
Deciphering the bone marrow inflammatory cytokine network in AML prognosis and immune evasion: A focus on the IL-1A-CCL3/4 axis as a novel therapeutic target
Abstract Background: Acute Myeloid Leukemia (AML) is characterized by a profoundly dysregulated bone marrow microenvironment (BME) that fost...
Liposomal mitoxantrone versus chidamide in relapsed/refractory peripheral T-cell lymphoma: Final analysis from the multicenter, prospective randomized phase 3 study
Abstract Background Outcomes for patients with relapsed/refractory (R/R) peripheral T-cell lymphomas (R/R-PTCLs) are poor. Single agent over...
Identification of novel, potent, and selective JAK2V617F inhibitors
Abstract The predominant oncogenic variant driving myeloproliferative neoplasms (MPNs) is the JAK2V617F substitution, where valine is replac...
Preliminary Results of A phase 1 study of the safety and tolerability of the combination of revumenib (REV) with gilteritinib (GILT) in Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)
Abstract Introduction: REV is an oral targeted menin inhibitor approved for treatment of R/R acute leukemia with KMT2Ar that also has demons...