Blood
Articles in this Issue
The weight of stress: Allostatic load as a predictor of vaso-occlusive episodes in adults with sickle cell disease
Abstract Introduction: Sickle cell disease (SCD) is a debilitating hemoglobinopathy caused by a point mutation in the HBB gene, inducing hem...
Long-term follow up of nivolumab/ipilimumab-primed immunotransplant in patients with Relapsed/Refractory DLBCL
Abstract Introduction: Patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL) have poor outcomes, particularly those...
KP104, a bifunctional C5 mAb–Factor h fusion protein, demonstrates sustained long-term efficacy and safety in complement inhibitor–naïve PNH patients: 2-year results from A phase 2 study with 8-week post-treatment safety follow-up.
Abstract Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, life-threatening hematologic disorder characterized by complement...
Safe: A multimodal, scalable and clinically-oriented comprehensive framework for synthetic data validation in hematology
Abstract Background. The emergence of Generative AI is expanding the use of Synthetic Data (SD) for ground-breaking applications, such as di...
Trends and disparities in mortality from sideroblastic anemia and liver diseases in US adults (1999–2023): A CDC wonder analysis
Abstract Introduction: Sideroblastic anemia and liver diseases are clinically distinct but often interlinked through sim...
Integrative profiling of t-follicular helper cells heterogeneity and tumor microenvironment signatures in angioimmunoblastic T cell lymphoma
Abstract Angioimmunoblastic T-cell lymphoma (AITL) is a rare subtype of mature T-cell lymphoma (TCL) that arises from T follicular helper (T...
Inverse association of legacy PFAS mixture exposure with neutrophil-to-lymphocyte ratio in United States adults: A survey-weighted analysis of the national health and nutrition examination survey (NHANES) 2005-2018
Abstract Background & Objective Per- and polyfluoroalkyl substances (PFAS) may alter immune function. We tested whether serum levels of...
Venetoclax and azacytidine in childhood primary advanced myelodysplastic syndromes, refractory/relapsed Acute Myeloid Leukemia and therapy-related myeloid diseases
Abstract Introduction. Refractory or relapsed acute myeloid leukemia (r/r-AML), myelodysplastic syndromes with excess blasts (MDS-EB), and t...
A pre-admission chemotherapy checklist: Improving timeliness of chemotherapy initiation in a malignant hematology inpatient unit
Abstract Introduction In an elective admission, patients are admitted to the hospital on a scheduled day for chemotherap...
The whole brain radiotherapy is a safe and effective backbone in primary central nervous system lymphoma: A 23-year real-world experience
Abstract Background The current treatment management for primary central nervous system lymphoma (PCNSL) relies on high-dose methotrexate (H...
Cytoreductive therapy reduces recurrent thrombosis in patients with myeloproliferative neoplasm-associated splanchnic vein thrombosis: A global abdominal/splanchnic thrombosis retrospective observational study (GASTRO-MPN) study of 757 patients
Abstract Background Patients with myeloproliferative neoplasms (MPNs) are at risk of splanchnic vein thrombosis (SVT). Prior studies failed...
Interim results of a quality improvement study evaluating subjective and objective sleep quality in hospitalized adults with acute leukemia
Abstract Background: Impaired sleep in hospitalized patients is associated with a myriad of adverse health outcomes. However, how sleep disr...
Improvement in kidney function after 12 months of voxelotor in sickle cell disease patients
Abstract Introduction: Sickle cell nephropathy (SCN) is characterized by glomerular and tubulointerstitial damage, as well as glomerular hyp...
Measuring success by different rulers: Heterogeneity in definition of outcomes in immune thrombocytopenia trials
Abstract Background: Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by low platelet coun...
Impact of obesity on inpatient outcomes in patients hospitalized with acute chest syndrome
Abstract Background: Acute chest syndrome (ACS) is a serious and potentially fatal complication of sickle cell disease. Obesity, a growing p...
Reattempt of tyrosine kinase inhibitor discontinuation after maintenance therapy with ponatinib in patients with chronic myeloid leukemia in the chronic phase: Result of JALSG CML RE-STOP219 study.
Abstract Objective: In the management of chronic myeloid leukemia (CML), treatment-free remission (TFR) following tyrosine kinase inhibitor...
Clinical outcome of hematopoietic stem cell transplantation for juvenile myelomonocytic leukemia: A Single center in China
Abstract Objective: To evaluate the safety and efficacy of hematopoietic stem cell transplantation (HSCT) in the treatment of juvenile myelo...
Investigating suspected germline STAG2 variants in myeloid neoplasms
Abstract BACKGROUND: Among cohesin complex genes, STAG2 is the most frequently mutated, prognostically unfavorable gene in high-risk MDS and...
Bridging the gap: Evaluating the impact of satellite clinics on CAR-T therapy access in the rural Southeast
Abstract Background: Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the treatment of relapsed or refra...
A prospective, single site, single-arm pilot study of CPX-351 (Vyxeos) in individuals <22 years with secondary myeloid neoplasms
Abstract Background and Significance: Secondary myeloid neoplasms (SMN) in children and adolescents are rare malignancies with dismal progno...
Efficacy and safety of the ROCK2-inhibitor belumosudil for chronic gvhd treatment: Multicenter retrospective analysis of a large german-austrian cohort of the belumosudil managed-access program.
Abstract Background: Chronic GvHD (cGvHD) is the most significant risk factor for late morbidity and mortality after allogeneic stem cell tr...
Prevalence and risk of aortic aneurysms in JAK2-positive myeloproliferative neoplasms: A multi-study review
Abstract Background: Myeloproliferative neoplasms (MPNs) harboring JAK2 mutations, particularly V617F, have been increasingly linked with va...
Quality of life reporting in randomized trials for indolent lymphomas: A systematic review by sponsor type
Abstract Background: Indolent lymphomas are incurable malignancies with extended disease courses and prolonged overall survival (OS). This l...
Health-related quality of life with belantamab mafodotin in patients with relapsed or refractory multiple myeloma (RRMM): An exploratory analysis of overall quality of life in dreamm-7
Abstract Introduction: Belantamab mafodotin (belamaf) is an antibody-drug conjugate targeting B-cell maturation antigen. In DREAMM-7 (NCT0424...
Outcomes of patients with light-chain amyloidosis after heart transplantation: A single center cohort.
Abstract INTRODUCTION: Systemic light chain (AL) amyloidosis is a plasma cell disorder characterized by the production of amyloidogenic mono...