Blood
Articles in this Issue
Evaluation of medical provider practice patterns in the assessment and management in heavy menstrual bleeding for patients on anticoagulation
Abstract Introduction: Heavy menstrual bleeding (HMB), traditionally defined as menstrual blood loss of greater than 80 mL per menstrual cyc...
Evaluating leukemogenic transmission via blood transfusion from genetically modified leukemic mice to healthy recipients
Abstract Background: Donor-derived leukemia after stem-cell transplantation is documented, yet the risk of transmitting leukemogenic cells v...
Targeting CD117 with engineered invariant natural killer T cells (iNKT Cells) as a novel approach for acute myeloid leukemia treatment
Abstract Background: Our research focuses on developing a CAR-based therapy for acute myeloid leukemia (AML) using engineered invariant natu...
Enhancing specificity in factor v leiden screening: Performance of the hemoclot quanti v-l assay
Abstract Introduction: Factor V Leiden (FVL) is an autosomal dominant prothrombotic disorder, that impacts activated Fac...
Craniofacial involvement is associated with poor prognosis in extranodal DLBCL patients
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous and aggressive lymphoma, with approximately one-third of cases...
Effect of avapritinib on skin lesions in patients with advanced systemic mastocytosis using a novel, artificial intelligence-based technology
Abstract IntroductionAdvanced systemic mastocytosis (AdvSM), which includes aggressive SM (ASM), SM with an associated hematologic neoplasm...
Differential impact of clonal hematopoietic mutations on 10-year atherosclerotic cardiovascular disease risk from a multidisciplinary chip clinic
Abstract Background: Clonal hematopoiesis (CH) is characterized by the expansion of the hematopoietic stem/progenitor pool in the setting of...
Correlation between CRLF2 expression by flow cytometry and FISH in patients diagnosed with B-cell acute lymphoblastic leukemia
Abstract Introduction / Objective: Philadelphia chromosome–like B-cell acute lymphoblastic leukemia (Ph-like B-ALL), also referred to as BCR...
Role of bortezomib maintenance therapy in the anti-CD38 antibody era: Interim analysis results of a randomized Phase III study for transplant-ineligible newly diagnosed multiple myeloma (JCOG1911/B-DASH Study)
Abstract Introduction Daratumumab (Dara) plus melphalan, prednisolone, and bortezomib (Bor) (D-MPB), followed by Dara maintenance therapy, h...
Trimodal single-cell profiling reveals principles of cell fate acquisition in human erythropoiesis.
Abstract Hematopoiesis is a highly dynamic and hierarchical process that gives rise to all blood cell types from multipotent hematopoietic s...
In Vivo hematopoietic stem cell (HSC) engineering and selection with CD90-targeted multiplexed virus-like particles (MVPs) for HSC gene therapy and cancer immunotherapy
Abstract Ex vivo hematopoietic stem cell (HSC) gene therapy can cure various blood and immune disorders. However, barriers persist regarding...
Quantitative real-time polymerase chain reaction coupled with high-resolution melting (HRM) for simultaneous detection and quantification of four isoforms of BCR::ABL1
Abstract Background The diagnosis and management of chronic myeloid leukemia (CML) critically rely on detecting and serially quantifying BCR...
Rivaroxaban in pediatric venous malformations complicated by thrombosis: Updated experience from a retrospective single-center cohort
Abstract Background and Aims Venous malformations (VMs) are the most prevalent subtype of congenital vascular malformations and may be compl...
Luspatercept in β-thalassemia: Meta-analysis of efficacy and safety across transfusion-dependent and non-transfusion-dependent populations
Abstract Background: Luspatercept is a first-in-class erythroid maturation agent approved for adult transfusion-dependent β-thalassemia. Pha...
Spatial transcriptomics identified dynamic and spatial-resolved niche cell and signal architecture for hematopoietic stem cell specification
Abstract Hematopoietic stem cell (HSC) transplantation remains limited by insufficient matched donors. Generating HSCs from pluripotent stem...
Maximizing the potential of optical genome mapping through comprehensive automated data analysis in multiple myeloma
Abstract Introduction: Identifying cytogenetics abnormalities (CAs) is essential to define prognosis in patients with newly diagnosed multip...
Phase 3 study (inMIND) of tafasitamab plus lenalidomide and rituximab for relapsed or refractory follicular lymphoma: Clinical characteristics and outcomes of high-risk patients
Abstract Introduction: Despite initial response to first-line therapy, most patients (pts) with follicular lymphoma (FL) experience relapse...
MYC-dependent permissiveness of PI3K hyperactivation renders metabolic vulnerability in R/R b-ALL
Abstract Significance Phosphoinositide-3 kinase (PI3K) and MYC are recognized as central components of a shared signaling network that regul...
Distinct sialylation profiles of neonatal and adult platelets revealed by lectin flow cytometry
Abstract Neonatal platelets differ from adult platelets in their activation thresholds, in vivo half-life, and hemostatic function. We and o...
Luspatercept combined with immunosuppressive therapy reduces inflammation in aplastic anemia by inhibiting monocyte pyroptosis
Abstract Abstract Background: Aplastic anemia (AA) is a bone marrow failure disorder caused by diverse etiologies. AA pathogenesis involves...
Clinical outcomes of patients with IDH1/IDH2-mutated clonal hematopoiesis: A single-center retrospective study
Abstract Introduction: Clonal hematopoiesis is defined by the expansion of hematopoietic stem or progenitor cells carry...
FOXO1⁺themis⁺ memory t cells underpin long-term remission after cytokine-armored CD19 CAR-t therapy in refractory lymphoma
Abstract In an extended 5-year follow-up of a single-arm, multicenter trial (NCT04833504) evaluating IL-7/CCL19-armored CD19 CAR-T (7×19 CAR...
Sickling kinetics drive genotype-specific impairment of RBC deformability in sickle cell disease
Abstract Introduction: Sickle cell disease (SCD) is an inherited hemoglobinopathy arising from a single point mutation in the β-globin gene...
Prospective observational cohort study to collect granular social determinants of health data for hematopoietic cell transplant patients
Abstract Background: Although patient (pt) social/financial barriers impact transplant (BMT) outcomes, comprehensive, granular social determ...
Prehabilitation prior to CAR T-cell therapy in non-Hodgkin lymphoma: Baseline physical function and toxicity outcomes
Abstract Background Emerging evidence suggests that baseline physical function may predict the toxicity of chimeric antigen receptor (CAR) T...