Blood
Articles in this Issue
MT-601 demonstrates favorable safety and durable responses in relapsed or refractory (r/r) non-Hodgkin lymphoma (NHL)
Abstract Background: Significant treatment advances, including anti-CD19 CAR-T cells and bispecific antibodies (BsAbs),...
Improvemf: Phase 1b trial of imetelstat plus ruxolitinib in patients with intermediate-2 or high-risk myelofibrosis
Abstract Introduction: Myelofibrosis (MF) is a type of myeloproliferative neoplasm characterized by ineffective hematopoiesis, aberrant expr...
Acalabrutinib versus venetoclax plus obinutuzumab in treatment-naive chronic lymphocytic leukemia: A real-world propensity score-matched study
Abstract Background: First-line treatment for chronic lymphoid leukemia (CLL) has shifted from chemoimmunotherapy to targeted therapies, inc...
Molecular subtype combined with peripheral blast clearance rate to optimize the treatment of newly diagnosed Acute Myeloid Leukemia: Interim analysis of the multicenter, Phase II study (IA+X 2024)
Abstract Background: For newly diagnosed acute myeloid leukemia (ND-AML), the traditional “3+7” induction is still the foundation of intensiv...
Low-intensity cytoreduction with low-dose cytarabine prior to blinatumomab for pediatric and AYA R/R ALL integrated with multi-omics analysis to discover predictive biomarkers: Initial results from JPLSG-ALL-R19-blin
Abstract Purpose: The prognosis for relapsed acute lymphoblastic leukemia (ALL) remains poor, highlighting the need for novel therapeutic st...
Synergistic correction of polycythemia vera phenotype via dual targeting of JAK2 and Gas6 in Jak2 exon 12 mutant mice
Abstract Introduction: Polycythemia vera (PV) is a chronic BCR-ABL1-negative myeloproliferative neoplasm driven by JAK2 mutations, causing e...
Phase 2 bellwave-003 cohort f: Updated clinical outcomes of nemtabrutinib in participants with relapsed or refractory marginal zone lymphoma
Abstract Introduction: Covalent Bruton tyrosine kinase inhibitors (BTKis) are approved for use in patients with relapsed or refractory (R/R)...
Protein degradation of MYC/GSPT1 combined with menin inhibition overcomes resistance to menin inhibition in KMT2A-rearranged Acute Myeloid Leukemia
Abstract BACKGROUND KMT2A rearranged (KMT2Ar) leukemias are an aggressive subset of acute leukemias with poor outcomes. Pharmacological inhib...
An actionable DNA repair defect in myeloid malignancies with U2AF1 S34 mutations
Abstract Mutations in the RNA splicing factor genes SRSF2, SF3B1, U2AF1 and ZRSR2 are present in >50% of patients with myelodysplasti...
Systematic literature review and meta-analysis on the safety of fibrinogen concentrate versus cryoprecipitate in bleeding surgical patients
Abstract Background: Fibrinogen concentrate (FC) and cryoprecipitate are plasma-derived products used to manage bleeding in patients with hy...
Pharmacological inhibition of polrmt mimicking polrmt rare variants associated with sideroblastic anemia, strongly inhibits proliferation and differentiation of human erythroblasts
Abstract Introduction Congenital sideroblastic anemia (CSA) result from abnormal erythroid differentiation related to mutations in genes inv...
Validation of the high-risk consensus genomic staging system in the era of bispecific antibodies: Role of NGS and cytogenetic reclassification
Abstract Introduction:The International Myeloma Working Group (IMWG) and International Myeloma Society (IMS) recently proposed a consensus h...
Investigating KAT2A protac therapy for targeting leukemic blast differentiation in acute myeloid leukaemia.
Abstract Introduction Acute myeloid leukaemia (AML) is a potentially fatal haematological malignancy characterized by the uncontrolled growt...
Leukapheresis for acute leukemia with hyperleukocytosis: Line complications, resource utilization, and early mortality outcomes
Abstract Background: Hyperleukocytosis (white blood cell [WBC] count >50–100 ×10³/µL) in acute leukemia can lead to leukostasis, tumo...
Multi-omics profiling of the gut Microbiota–Metabolism–Immunity axis reveals predictive biomarkers of treatment response and survival in diffuse large B-cell lymphoma
Abstract Background The immunometabolic interface between gut microbiota and host immunity has emerged as a critical regulator of systemic ma...
MDX2003, a novel tetraspecific T cell engager-expander targeting CD19xCD20xCD3xCD28, demonstrates potent preclinical activity against B cell malignancies
Abstract Background: CD19 and CD20 directed therapies, including CAR-T cells, monoclonal antibodies, and bispecific T cell engagers have demo...
Construction and evaluation of a prognostic model for patients with Acute Myeloid Leukemia
Abstract Background： Acute myeloid leukemia (AML) is a group of aggressive, heterogeneous, malignant diseases and is the most common type o...
Disproportionate risk of hematologic malignancies in sickle cell disease (SCD) across age strata: A multicenter matched cohort analysis
Abstract Background: Sickle Cell Disease (SCD) is a known risk factor for hematologic malignancies, but age-related variation in this risk r...
Use of apixaban for the prevention of thrombosis in children with coronary artery aneurysms secondary to kawasaki disease
Abstract Background: Kawasaki disease (KD) is the leading cause of acquired heart disease in children in developed count...
Impact of race and social deprivation on outcomes with modern day induction therapy in patients with newly diagnosed multiple myeloma: An ASH research collaborative data hub analysis
Abstract Introduction: While the incidence of multiple myeloma (MM) is 2-3 fold higher in Black compared to white individuals, the impact of...
Avascular necrosis of the femoral head in children and adolescents with sickle cell disease presenting with HIP PAIN
Abstract Background: Avascular necrosis is a progressive and potentially debilitating complication of sickle cell disease (SCD). It can affe...
Impact of disease genotype and severity of anemia on myocardial extracellular volume fraction in sickle cell disease (SCD) and non-SCD hemolytic anemias
Abstract Background: Sickle cell disease (SCD) is associated with a unique cardiomyopathy characterized by diastolic dysfunction superimpose...
SH2B3 expression predicts selinexor sensitivity in acute myeloid leukemia
Abstract Background Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy. Despite recent therapeutic advances, patients co...
Acute depletion of HOXA9 reveals its direct role in cis-elements regulation and 3D genome organization during Acute Myeloid Leukemia
Abstract In normal hematopoiesis, HOXA9 maintains early hematopoietic progenitors and is silenced during differentiation. Failure to silence...
Risk factors for transplant-associated thrombotic microangiopathy in pediatric patients undergoing haploidentical hematopoietic stem cell transplantation
Abstract Background: Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe life-threatening endothelium-mediated complicatio...