Blood
Articles in this Issue
Updated results of a first-in-human, Phase Ⅰa/Ⅰb study of QLS32015 (GPRC5D×CD3) in patients (pts) with relapsed/refractory multiple myeloma (RRMM)
Abstract Background: QLS32015 is a novel cis-link G-protein-coupled receptor class 5 member D (GPRC5D)×CD3 bispecific antibody, utilizing hig...
Impact of short-form, case-based continuing medical education on community clinicians' knowledge and competence in optimizing bispecific antibody therapy for Relapsed/Refractory multiple myeloma
Abstract Background: Despite progress in the management of multiple myeloma (MM), the disease remains largely incurable. Patients eventually...
Prolonged venetoclax (VEN) plus hypomethylating agent (HMA) therapy in non-promyelocytic AML: A single-centre retrospective cohort study
Abstract Background: This retrospective study aimed to analyze and evaluate the progression-free survival (PFS) and overall survival (OS) of...
Development of methods for enriching microglia nuclei from frozen brain samples to study the effect of CHIP on Alzheimer's disease
Abstract Background: Clonal hematopoiesis of indeterminate potential (CHIP) associates with increased risk of age-relate...
Mixed autoimmune hemolytic anemia as a rare initial presentation of systemic lupus erythematosus
Abstract Introduction: Autoimmune hemolytic anemia (AIHA) is a rare disorder in which autoantibodies produced by the immune system attach to...
Real-world experience with first-line regimens in transplant-ineligible patients with multiple myeloma
Abstract Introduction Regimens based on bortezomib and lenalidomide have been a mainstay of treatment for transplant-ine...
Hiding beneath the surface: Paraneoplastic pemphigus as a rare presentation of follicular lymphoma
Abstract Introduction: Paraneoplastic pemphigus (PNP) is a rare autoimmune mucocutaneous blistering disorder associated...
Impact of preexisting chronic obstructive pulmonary disease on in-hospital outcomes in first-time acute chest syndrome: A nationwide analysis, 2016–2022
Abstract Background: Acute chest syndrome (ACS) is a severe and potentially life-threatening complication of sickle cell disease (SCD), repr...
Functional fitness of CAR-T cells in the bone marrow following anti-BCMA durcabtagene autoleucel (PHE885) therapy correlate with prolonged PFS in RRMM
Abstract There have been significant advances in therapy for multiple myeloma (MM). The development of chimeric antigen receptor (CAR) engin...
FLT3 (CD135) expression in pediatric AML is associated with specific disease characteristics and worse outcome in the setting of sorafenib theraphy: A report from the Children's Oncology Group AAML1031 protocol.
Abstract Introduction: FLT3/CD135 (also known as FLK2) is a membrane-bound surface protein encoded by the FLT3 gene and part of the class II...
Maternal and fetal risks in patients with sickle cell disease: Results of the retrospective drepamom study
Abstract Introduction The association between pregnancy and sickle cell disease (SCD) is increasingly common. These two conditions exacerbat...
P300/CBP acetyltransferase inhibition and degradation disrupt oncogenic transcriptional programs and reveal epigenetic vulnerabilities in multiple myeloma
Abstract Background: The histone acetyltransferases (HATs) P300 and CBP are critical transcriptional co-activators that regulate gene expres...
Oral n-myristoyltransferase inhibitor zelenirstat for adults with Relapsed/Refractory Acute Myeloid Leukemia (AML): A phase 1 trial in progress
Abstract Background: Relapsed/refractory (R/R) AML remains an area of high unmet need despite recent therapeutic advances. Zelenirstat (PCLX...
A rubric‑based comparison of code red and specialists in managing CAR‑T–Related cytokine release syndrome and icans
Abstract Background Large language models (LLMs) coupled with retrieval-augmented generation (RAG) can deliver point-of-...
B cell kinetics on next generation sequencing after CAR T-cell therapy in multiple myeloma
Abstract Introduction: B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell (CAR T) therapies such as ciltacabtagene a...
National temporal trends and demographic disparities in primary immunodeficiency-related mortality in the United States, 1999–2024
Abstract Background: Primary immunodeficiency disorders (PIDs) comprise hundreds of rare, genetically defined conditions...
Systematic analysis of gene mutations in Chinese multiple myeloma patients.
Abstract Background: Due to the high genetic complexity and heterogeneity, the treatment responses and prognosis of patients with multiple my...
Dual targeting of ROR1 and ROR2 with glycoengineered antibodies elicits potent and selective immunotherapy in hairy cell leukemia
Abstract Receptor tyrosine kinase-like orphan receptors 1 and 2 (ROR1 and ROR2) are oncoembryonic antigens aberrantly expressed on hairy cel...
Screening for clonal hematopoiesis in patients with β-hemoglobinopathies who are candidates to transplant approaches
Abstract Background. Allogeneic hematopoietic cell transplantation (alloHCT) represents a currently available curative option for patients w...
Mechanistic dissection of venetoclax sensitivity in AML through single-molecule BCL2 protein complex profiling and mutation-specific apoptotic rewiring
Abstract Venetoclax (VEN) combined with hypomethylating agents (HMA) has improved response rates in elderly or unfit acute myeloid leukemia...
Varaser : Genetic individual identification free from direct raw data sharing
Abstract #Background Sequencing technology is widely used not only in life sciences research but also in the fields of disease diagnosis and...
Is IMWG frailty-score-adjusted dosing the right approach to improve toxicity and outcomes in FRAIL patients? Results from the UK-MRA FiTNEss trial in newly diagnosed myeloma patients ineligible for ASCT.
Abstract Introduction Frail myeloma (MM) patients remain at risk of greater toxicity and shorter survival outcomes. Approaches to improve th...
Optimizing lenalidomide therapy in renal impairment: Analysis of renal response in the prospective remnant study in transplant-eligible newly diagnosed multiple myeloma
Abstract Background: Renal impairment (RI) is a serious complication in multiple myeloma (MM), associated with poor overall survival and incr...
Adult hemophagocytic lymphohistiocytosis: A multicenter retrospective analysis of etiology and impact on survival in China
Abstract Background Hemophagocytic lymphohistiocytosis (HLH) is a rare yet life-threatening hyperinflammatory syndrome characterized by pers...
Venetoclax combined with three-day multi-frequency decitabine (DEC3-VEN) VS venetoclax combined with azacitidine in elderly patients with Acute Myeloid Leukemia：a phase III, prospective, multicenter, randomized controlled trial
Abstract Background: Elderly patients with acute myeloid leukemia (AML) (≥60 years) have a poor prognosis and low long-term survival due to f...