Blood
Articles in this Issue
Patient characteristics and treatment outcomes with Pola-R-CHP: A real-world study of patients with previously untreated diffuse large B-cell lymphoma (DLBCL) in the United States (US)
Abstract Background: The Phase III POLARIX study reported improved progression-free survival (PFS) of polatuzumab vedotin (Pola) in combinat...
A ubiquitin specific protease (USP) network regulates wnt/β-catenin activity in myeloid leukemia cells
Abstract Canonical Wnt signalling is an important regulator of haematopoietic stem/progenitor cells (HSPC) and frequently dysregulated in my...
Prognostic impact of donor KIR genotypes on clinical outcomes in pediatric allogeneic hematopoietic stem cell transplantation
Abstract Prognostic Impact of Donor KIR Genotypes on Clinical Outcomes in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Backg...
Real-world data of adolescents and young adults with acute lymphoblastic leukemia treated with a modified GMALL protocol in India: Treatment outcomes and challenges
Abstract Adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) treated using pediatric-inspired regimens have improved...
Coexisting trisomies of chromosomes 12 and 19 define a cytogenetic subgroup of IgG+ CLL enriched for BIRC3 mutations
Abstract Introduction: Coexisting trisomies of chromosomes 12 and 19 define a cytogenetic subgroup of CLL (+12+19 CLL) with shared clinicobi...
Momelotinib's unique polypharmacology supports indication expansion beyond myelofibrosis
Abstract Momelotinib (Ojjaara / Omjjara), a clinically differentiated JAK inhibitor, not only addresses symptoms and splenomegaly associated...
Prevalence of iron deficiency among youth with sickle cell disease
Abstract Sickle cell disease (SCD) is an inherited hemoglobinopathy affecting up to 100,000 people in the United States. While pain, acute c...
Impact of infectious complications on outcomes after allogeneic hematopoietic stem cell transplantation in elderly patients: A geth-TC study
Abstract Introduction Allogeneic hematopoietic stem cell transplantation (alloHSCT) is increasingly performed in elderly patients, a populat...
Benefits of hydroxyurea in hemoglobin SC: Results of the open-label phase of the prospective identification of variables as outcomes for treatment (PIVOT) trial
Abstract Introduction: Hydroxyurea treatment is the standard of care for people with sickle cell anemia (HbSS or HbS/beta-zero thalassemia)...
Closing the gap: Genetic profiling of B-cell lymphomas using integrative whole-exome and whole-transcriptome sequencing
Abstract Background: The treatment of B cell lymphomas has evolved significantly; however, a portion of patients still experience inferior o...
A TFPI missense variant provides protection against severe febrile neutropenia in pediatric Acute Myeloid Leukemia
Abstract Background: Toxicity due to antileukemic agents is common in acute myeloid leukemia (AML) patients and significantly impacts morbid...
Bone marrow endothelial progenitor cells drive TKI resistance in CML via SEMA4D-plexin B1-mediated metabolic reprogramming
Abstract Introduction Resistance to tyrosine kinase inhibitors (TKIs) remains a major therapeutic challenge in chronic myeloid leukemia (CML...
Systemic mastocytosis with concurrent plasma cell myeloma: A rare a literature-based review of clinical, molecular, and pathologic features
Abstract Background: Systemic mastocytosis (SM) is a rare clonal mast cell disorder that may co-occur with other hematologic neoplasms (SM-A...
Von willebrand factor levels show independent prognostic significance in patients with AL amyloidosis treated with daratumumab-based therapies
Abstract Cardiac involvement remains the key prognostic factor in AL amyloidosis, but myocardium is part of an extensive vascular system cov...
Inotuzumab ozogamicin as salvage therapy for refractory/relapsed B-cell acute lymphoblastic leukemia following the failure of chimeric antigen receptor T cell therapy and allogeneic hematopoietic stem cell transplantation
Abstract Although inotuzumab ozogamicin (InO) has been approved as an effective agent for patients with refractory/relapsed (r/r) B-cell acu...
Pediatric-inspired USC ALL regimen vs hyper-CVAD in adults with ph-negative ALL: Real-world outcomes including blinatumomab in a predominantly hispanic cohort.
Abstract Introduction: Pediatric-inspired regimens have improved outcomes in adolescents and young adults with acute lym...
Direct comparison of crovalimab versus eculizumab in paroxysmal nocturnalhemoglobinuria: A systematic review and meta-analysis of randomized controlled trials
Abstract Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, clonal hematopoietic stem cell disorder characterized by complem...
Contact modality and contact intensity over time among community health workers in adult sickle cell disease
Abstract Background The effectiveness and efficiency of medical center-based Community Health Workers, also known as Patient Navigators (PNs...
Impact of additional genetic variants in the course of erdheim-chester disease and their evolution on treatment: A multicentric longitudinal Study of 445 french patients
Abstract Introduction. Erdheim-Chester disease (ECD) is a histiocytic disorder with activating MAPK (mitogen-activated protein kinases) sign...
Underreporting of prognostic factors in real-world studies for bispecifics in relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL)
Abstract BACKGROUND: Real-world patients receiving a bispecific therapy (epcoritamab or glofitamab) for third-line plus (3L+) treatment for...
Epcoritamab (epcor) monotherapy offers long-term disease control in large B-cell lymphoma (LBCL): NHL-1 subgroup analysis in patients with prior chimeric antigen receptor T-cell (CAR T) therapy from the 3-year follow-up
Abstract INTRODUCTION: CAR T is approved in the relapsed/refractory (R/R) LBCL. Patients (pts) with R/R LBCL who progressed after CAR T ther...
Sepsis induces platelet‑activating anti‑PF4 antibodies with potential protective role against secondary bacterial infection
Abstract Background: Increasing evidence indicates the presence of anti–platelet factor 4 (PF4)/heparin antibodies in some patients with sep...
Pre-infusion ADAMTS13 and VWF levels are associated with clinical outcomes of patients receiving CAR-T cell therapy
Abstract Background: Chimeric antigen receptor T (CAR-T) cell therapy has been a breakthrough in the management of relapsed/refractory B cel...
CRISPR-tica.ai: A function-informed generative modeling pipeline for prioritizing drug discovery in AML
Abstract A systematic approach to identifying novel therapeutic strategies is essential for expanding curative options in hematopoietic mali...
Duvelisib in patients with relapsed/refractory peripheral T-cell lymphoma: Final results from the phase 2 PRIMO trial - impact of prior therapy and expanded safety analysis
Abstract Introduction Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of aggressive lymphomas that have a p...