Blood
Articles in this Issue
Outcomes of CD20xCD3 bispecific antibody therapy in adult patients with Relapsed/Refractory transformed indolent lymphoma
Abstract Introduction Though transformed indolent lymphomas (tiNHL) have historically been associated with poor outcomes in the relapsed or...
Efficacy and safety of salvage therapies in relapsed/refractory Acute Myeloid Leukemia: A systematic review and network meta-analysis
Abstract Background: Relapsed or refractory acute myeloid Leukemia (R/R AML) poses significant therapeutic challenges due to its aggressive...
Investigating the clonal and biological underpinnings of systemic mastocytosis with an associated hematological neoplasm
Abstract Systemic mastocytosis (SM) is a disease characterized by the clonal expansion of abnormal mast cells driven by KIT D816V activating...
TADA1 plays a regulatory role in erythropoiesis and the expression of HBG.
Abstract Sickle cell anemia and β-thalassemia are caused by mutations in the adult β-globin gene. Reactivation of fetal γ-globin expression...
Acute lymphoid leukemia burden attributable to occupational benzene exposure from 1990-2021: Global patterns, trends, and implications for prevention
Abstract Background: Acute lymphoid leukemia (ALL), while primarily a pediatric malignancy, affects adults and is influenced by both genetic...
Mortality in immune TTP remains unpredictable: Shortcomings of prediction models despite machine learning advances
Abstract Background Despite advances in the diagnosis and treatment of immune thrombotic thrombocytopenic purpura (iTTP), recent mortality es...
Efficacy and safety of l-glutamine for reducing complications in sickle cell disease: A systematic review and meta-analysis original article
Abstract Introduction Sickle cell disease (SCD) is a blood disorder that is genetic and can lead to cyclical occurrences...
Trilaciclib for the prevention of chemotherapy-induced myelosuppression: A systematic review and meta-analysis
Abstract Introduction Chemotherapy-induced myelosuppression (CIM) is among the most clinically significant hematologic toxicities associated...
Evaluating thymic stromal lymphopoietin (TSLP) as a biomarker in acute graft versus host disease
Abstract Background Steroid refractory acute graft versus host disease of the lower gastrointestinal tract (SR-LGI-aGVHD...
Involvement of bone marrow, liver, spleen and extranodal number were associated with poor outcome in angioimmunoblastic T-cell lymphoma (AITL) patients
Abstract Background ： Angioimmunoblastic T-cell lymphoma (AITL) represents a distinct subtype of peripheral T-cell lymphoma (PTCL). Primari...
Evolving prognostic impact of B symptoms in non-Hodgkin lymphoma: A competing-risks analysis of SEER data, 2010–2019
Abstract Background: Constitutional B symptoms, including fever, night sweats, and unintentional weight loss, have long been recognized as a...
Zanubrutinib and venetoclax as initial therapy for CLL/SLL with obinutuzumab triplet consolidation in patients with detectable minimal residual disease (BruVenG).
Abstract Introduction Bruton's tyrosine kinase inhibitors (BTKi), anti-CD20 antibodies, and B cell lymphoma 2 inhibitors (BCL-2i) are essenti...
Thalassemia in europe: A cross-border real-world data analysis from the radeep registry
Abstract Introduction Advances in understanding the pathophysiology and clinical heterogeneity of Thalassemia (THAL) have enabled the develo...
Longitudinal single-cell profiling of the bone marrow heterogeneity identifies the T-cell niche supporting cancer persister cells in follicular lymphoma
Abstract Follicular lymphoma (FL) disease trajectory is characterized by a protracted preclinical stage, followed by iterative cycles of rem...
Role of ferroptosis in aGVHD-induced liver tissue damage: Mediation by Acsl4-regulated PUFA-pls
Abstract Introduction: Acute graft-versus-host disease (aGVHD) is a life-threatening complication of allogeneic hematopoietic stem cell tran...
Chronic kidney disease risk stratification in compound sickle cell disease variants: A single center review
Abstract Background: Chronic kidney disease (CKD) constitutes a major complication in sickle cell disease (SCD). Traditional SCD nephropathy...
Venetoclax-azacitidine-chidamide plus CAG (CACAG-VEN) versus “3+7” induction chemotherapy in Intermediate-adverse Acute Myeloid Leukemia: Efficacy and safety
Abstract Venetoclax-Azacitidine-Chidamide Plus CAG (CACAG-VEN) versus “3+7” Induction Chemotherapy in Intermediate-Adverse Acute Myeloid Leu...
Myeloproliferative neoplasm driver mutations (JAK2/CALR/MPL) in chronic myelomonocytic leukemia are associated with an increased risk of blast transformation
Abstract Introduction Chronic myelomonocytic leukemia (CMML) is a myeloid neoplasm with overlapping features of myelodysplastic syndromes (M...
Real-world comprehensive single-institution analysis of AML with TP53-mutation
Abstract Intro Acute myeloid leukemia (AML) with TP53 mutations (TP53m) are associated with dismal outcomes with median...
Real-world effectiveness and corticosteroid-sparing effects of belumosudil in chronic gvhd: A multi-database analysis
Abstract Introduction: Standard first-line therapy for chronic graft-versus-host disease (cGVHD) includes systemic oral glucocorticoid (GC)...
HLH-JAK, the first OPEN-label, phase II study evaluating ANTI-JAK1 itacitinib, for NON severe HLH in adults.
Abstract Background: HLH results in dysregulation of the immune system activation, characterized by excessive pro-inflammatory production, w...
Ex vivo evaluation of the procoagulant effect of NXT007 prophylaxis in people with Hemophilia A without factor VIII inhibitors: Phase I/II study (NXTAGE)
Abstract Introduction: NXT007, an emicizumab-based next-generation bispecific antibody, mimics the cofactor function of activated factor VII...
Combination therapy with methotrexate, ifosfamide, cytarabine, dexamethasone and rituximab (R-MIAD) improves clinical outcomes in primary central nervous system lymphoma: A monocentric retrospective observational study
Abstract Background: High-dose methotrexate (HD-MTX) based combination chemotherapy is the first-line induction regimen for the treatment of...
Treatment setting matters: Academic cancer centers deliver superior survival in MALT lymphoma – an NCDB analysis of 77,000 patients
Abstract Background Marginal zone lymphoma (MZL) is an indolent subtype of B-cell non-Hodgkin lymphoma, accounting for a...
Prognostic significance of pulmonary involvement in idiopathic multicentric castleman disease
Abstract Background Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder stratified into non-severe and s...