Blood
Articles in this Issue
Reasons for treatment discontinuation in multiple myeloma: Insights from the PREAMBLE registry
Abstract Introduction : Despite treatment (tx) advances in multiple myeloma (MM), patients (pts) continue to face shortened survival compare...
CD7-targeted CAR-T cell therapy showed a high efficacy for 30 patients with relapsed or refractory central nervous system T-cell lymphoblastic leukemia/lymphoma
Abstract Introduction CD7-targeted chimeric antigen receptor (CAR) T-cell therapy has demonstrated efficacy and safety in treating T-cell ac...
Clinical spectrum of hereditary hemorrhagic telangiectasia (HHT): Data from the comprehensive hht outcomes registry of the United States (CHORUS)
Abstract BACKGROUND Hereditary hemorrhagic telangiectasia (HHT) is the second most common inherited bleeding disorder (IBD) worldwide, affli...
Implementation of an innovative hospital at home program for patients with hematalogic malignancies
Abstract Introduction: Patients with aggressive hematologic malignancies have high rates of inpatient admissions. Specifically, patients rec...
SRSF2 mutation-induced CHD8 exon skipping represents a novel pathogenic mediator and therapeutic dependence in chronic myelomonocytic leukemia (CMML)
Abstract Introduction SRSF2, a splicing factor regulating both constitutive and alternative splicing (AS), is mutated in >40% of CMML...
Direct IL-6 sequestration with siltuximab rescues CAR T-cell proliferation from inflammatory suppression: A longitudinal multi-omic analysis supporting a paradigm shift in CRS management
Abstract Background: Interleukin-6 (IL-6) drives Cytokine Release Syndrome (CRS), a major toxicity of CAR T-cell therapy. The standard-of-ca...
The impact of public versus private health care services in the treatment of diffuse large B-cell lymphoma in Brazil: An analysis from the bra-DLBCL multicenter, retrospective real-world registry
Abstract Introduction Despite the improvement in management of diffuse large B-cell lymphoma (DLBCL) in recent years, th...
Association of obstructive sleep apnea with readmission and healthcare utilization in adults with sickle cell disease: A propensity-matched analysis of national readmission data
Abstract Background: Obstructive sleep apnea (OSA) is a prevalent and consequential comorbidity in sickle cell disease (SCD). The nocturnal...
Treatment with an EYA2 inhibitor prolongs survival of SIX1-expressing murine T-cell leukemias
Abstract Background: The CALM-AF10 (PICALM-MLLT10) fusion, found in 5-10% of pediatric T-ALLs (T-cell acute lymphoblasti...
Assessing the prevalence of sickle cell retinopathy in clinical practice
Abstract Sickle cell retinopathy (SCR) is a common, vision-threatening complication of sickle cell disease (SCD), yet adherence to national...
Trends and outcomes associated with atrial fibrillation in patients hospitalised with non-Hodgkin lymphoma - insights from national inpatient sample (NIS) database (2016-2022)
Abstract Background: Non-Hodgkin Lymphoma (NHL) is one of the most widespread malignancies in the United States. It constitutes approximatel...
Identifying treatment response in AML through a multi-omics classifier of malignant cell states
Abstract Background: Therapy resistance in Acute Myeloid Leukemia (AML) remains a major clinical challenge, yet its underlying cellular and m...
Inhibition of telomerase and ALT pathways in MDS/AML cell lines
Abstract Background: The ability of human cancer cells to maintain telomere length over successive cell divisions rapidly emerged as an adap...
Epidemiological and molecular analysis of thalassemia (Beta Globin Gene) in the heterogeneous population of gwadar, Pakistan
Abstract Heterogeneous Population of Gwadar, Pakistan Introduction and objective: Beta-thalassemia remains one of the most serious hereditar...
Central nervous system involvement in acute myeloid leukemia: A national analysis of inpatient outcomes using the 2022 national inpatient sample
Abstract Background: Central nervous system (CNS) involvement in acute myeloid leukemia (AML) is rare but portends worse outcomes. However, p...
Pirtobrutinib, a non-covalent BTK inhibitor, enhances T-cell anti-tumor immunity in chronic lymphocytic leukemia (CLL)
Abstract INTRODUCTION Covalent Bruton tyrosine kinase inhibitors (cBTKi) transformed the treatment of CLL and mantle cell lymphoma (MCL). cBT...
Evaluation of endothelial activation and stress index (EASIX) formulae in patients with compound heterozygosity for hb s and β-thalassemia: Correlation with specific proteins of disease activity
Abstract Background: Activation of vascular endothelium, the inner lining of blood vessels, has been previously reported in sickle cell dise...
Subtype-specific son isoform expression in Acute Myeloid Leukemia revealed by targeted long-read RNA sequencing
Abstract Background: The SON gene encodes a large nuclear protein that plays essential roles in RNA splicing, nuclear speckle integrity, and...
Prospective analysis and clinical implications of therapy-related clonal hematopoiesis in adolescent and young adult survivors of acute lymphoblastic leukemia
Abstract Adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) are exposed to cytotoxic chemotherapy early in life, whi...
Venous thromboembolism in hospitalized tuberculosis patients: Incidence, racial disparities, and factors associated with in-hospital mortality: An observational study
Abstract Background: Tuberculosis (TB) induces a significant systemic hypercoagulable state driven by chronic inflammation, endothelial dysfu...
Protamine Overdose–Associated coagulopathy in the setting of post-PCI RCA dissection and cardiac tamponade: A hematologic management dilemma
Abstract Background: Protamine sulfate is widely used to reverse heparin anticoagulation in interventional cardiology. W...
The TEMPI syndrome: Unique patient specific monoclonal antibodies as tools for target antigen discovery
Abstract BACKGROUND. In 2011, we discovered the TEMPI syndrome. TEMPI is a rare monoclonal gammopathy of clinical significance (MGCS) with p...
Safety and immunomodulatory effects of siltuximab prophylaxis prior to standard of care CD19 directed chimeric antigen receptor T-cell (CD19.CART) therapy for B-cell lymphomas: Final phase I trial results
Abstract Introduction: CD19.CART is highly effective for B-cell non-Hodgkin lymphomas (NHL). However, cytokine release syndrome (CRS) and im...
S100A12-Orchestrated Macrophage-ER stress crosstalk in MDS: Mechanisms and precision therapeutic targeting
Abstract Background: Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders originating in the bone marrow. Current ch...
Rare germline complement gene variants in severe aplastic anemia
Abstract Background: Severe aplastic anemia (SAA) and paroxysmal nocturnal hemoglobinuria (PNH) are strongly associated; the AA/PNH syndrome...