Blood
Articles in this Issue
High efficacy of azacitidine combined with lenalidomide in TP53 mutation-positive and other high-risk myelodysplastic neoplasms
Abstract Background Myelodysplastic neoplasms (MDS) are heterogeneous clonal hematopoietic neoplasms, and TP53 mutations were regarded as ad...
Real-world outcomes in older adults with triple-class exposed multiple myeloma
Abstract Introduction: Triple-class exposed (TCEx) multiple myeloma (MM) patients—those previously treated with an immunomodulatory agent (I...
Epidemiological trends in leukemia and heart failure-associated mortality: A CDC wonder database analysis
Abstract Background Leukemia and heart failure (HF) are individually associated with high morbidity and mortality. However, the intersection...
Single center updated analysis of patients with Relapsed/Refractory peripheral T-cell lymphoma treated with linperlisib.
Abstract Peripheral T-cell lymphoma (PTCL) and cutaneous T-cell lymphoma (CTCL) are aggressive malignancies with limited effective treatment...
HIV-1–Infected SCD patients exhibit milder sickle cell disease and suppressed antiviral innate immune responses
Abstract Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by chronic hemolytic anemia and complex pathology. SCD pat...
Imatinib in chronic myeloid leukemia: A comparative assessment of patients in pivotal clinical trials and real-world settings
Abstract Introduction: Several tyrosine kinase inhibitors (TKIs) are now available for the management of patients with chronic myeloid leuke...
Oxygen dependency as a critical regulatory axis affecting hematopoietic stem and progenitor cell function
Abstract Hematopoietic stem (HSCs) and progenitor cells (HPCs) are responsible for lifelong replenishment of blood and immune cells and are...
Real-world measurable residual disease (MRD) testing patterns and associated outcomes in patients with Philadelphia-negative B-cell acute lymphoblastic leukemia
Abstract Background:Measurableresidual disease (MRD) is an established prognostic biomarker in B-cell acute lymphoblastic leukemia (B-ALL) w...
Phase 2 trial of encorafenib plus binimetinib for patients with BRAF V600 mutated relapsed/refractory hairy cell leukemia
Abstract Background: Hairy cell leukemia (HCL) is an indolent B-cell leukemia characterized by durable complete remissions to purine analogs...
Improved survival in Philadelphia Chromosome–Positive acute lymphoblastic leukemia with pre-transplant second- and third-generation TKIs and post-transplant prophylactic maintenance: A study from the EBMT ALWP
Abstract Background: The use of tyrosine kinase inhibitors (TKIs) has improved the prognosis of patients with Philadelphia chromosome-positi...
A machine learning approach identifies a transcriptomic signature predicting treatment-free remission in chronic myeloid leukemia
Abstract Introduction Treatment-free remission (TFR) is currently the ultimate goal for patients with chronic myeloid leukemia (CML). Howeve...
Low-intensity focused ultrasound with microbubbles enhances CD20 monoclonal antibody delivery across the blood-brain barrier in primary central nervous system lymphoma
Abstract Abstract Objective: The objective of this study is to utilize low-intensity focused ultrasound (LIFU) in conjun...
Avoidance of ATG improves outcomes in double-cord blood transplantation for hematological malignancies
Abstract Background Umbilical cord blood transplantation (CBT) is an alternative source of hematopoietic stem cells providing access to cura...
Burnout in sickle cell disease-focused hematology-oncology trained providers: A national cross-sectional study
Abstract Introduction: Burnout is defined by emotional exhaustion, depersonalization, and reduced personal accomplishment. It affects roughl...
Antiphospholipid antibodies (Anti-β2GPI/B2GPI) prime neutrophil NLRP3 inflammasome activation via TLR2/4 signaling
Abstract Background: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of antiphospholipid antibodies...
XS003, an amorphous re-formulation of nilotinib, demonstrates improved dose linearity and minimal food effect, reducing the risk of QT-prolongation at fed conditions
Abstract Background: Crystalline formulated nilotinib (Tasigna®) is an established tyrosine kinase inhibitor benefiting patients with chroni...
Evaluation of the maternal-fetal transfer of liposomal daunorubicin and cytarabine in an ex vivo human placenta perfusion model to inform Acute Myeloid Leukemia therapy
Abstract Background & significance: Acute myeloid leukemia (AML) in pregnancy poses a therapeutic challenge and necessitates multidiscip...
Trials in progress: Phase IB/II of CPX-351 as maintenance therapy in AML patients ineligible for bone marrow transplantation
Abstract Acute myeloid leukemia (AML) patients have a high risk of relapse. In patients ineligible for allogenic hematopoietic stem cell tra...
External validation of the early-stage classic Hodgkin lymphoma (cHL) international prognostication index (E-HIPI) in the german Hodgkin study group (GHSG) unfavorable clinical trials
Abstract Background: Although progression-free survival (PFS) in early-stage (ES) classic Hodgkin Lymphoma (cHL) is high, there remains a su...
XPO1 inhibition by selinexor blocks nucleo-cytoplasmic trafficking of multiple members of the NF-kb family in MPN cell lines and primary myelofibrosis cells
Abstract Introduction: Selinexor, a first-in-class oral selective XPO1 inhibitor, in combination with ruxolitinib in JAK inhibitor-naïve pat...
Challenges in comparing outcomes of frontline clinical trials for diffuse large B-cell lymphoma patients selected based on the international prognostic index: A real-world analysis from the danish lymphoma registry
Abstract Background: The International Prognostic Index (IPI) has been utilized in various frontline clinical trials to identify trial-eligi...
Characterization and risk factors of transplantation-associated thrombotic microangiopathy (TA-TMA): Increased incidence associated to post-transplant cyclophosphamide (PTCy) prophylaxis.
Abstract Introduction Transplant-associated thrombotic microangiopathy (TA-TMA) is a potentially severe post-transplant...
Single-cell insights into acute myeloid leukemia treated with venetoclax-based therapy
Abstract Introduction Acute myeloid leukemia(AML) is a heterogeneous malignancy marked by impaired myeloid differentiation and resistance to...
Wide variability and inconsistency in reporting of results of Myelodysplastic Syndromes/neoplasms (MDS) clinical trials: An icMDS systematic review of published manuscripts
Abstract Introduction: Standardized reporting of clinical trials results for MDS is essential to improve clinical interpretation and cross-st...
Clinical impact of predicted indirectly recognizable HLA epitopes (PIRCHE) in single unit cord blood transplantation using tacrolimus and methotrexate for graft-versus-host disease prophylaxis
Abstract Background: The Predicted Indirectly Recognizable HLA Epitopes (PIRCHE) algorithm estimates the potential for indirect recognition...