Blood
Articles in this Issue
Predictive value of lung function results for sleep-disordered breathing in children with sickle cell disease: A multicenter cross-sectional study
Abstract Background: Lung function abnormalities and sleep-disordered breathing are more prevalent in children with sickle cell disease (SCD...
Targeting the ARHGAP18/PI3K/AKT axis with vincristine and cytarabine synergistically suppresses senescence and induces apoptosis in AML
Abstract Background: Cytarabine-based regimens remain the backbone of AML induction and consolidation therapy, yet drug resistance and relap...
Castleman disease as a spectrum: Characterization of novel subtypes using data from the spanish GELTAMO registry
Abstract Introduction Castleman disease (CD) unrelated to HHV-8 or POEMS syndrome comprises a heterogenous group of disorders characterized...
Outcomes of pregnancies in sickle cell patients treated with hydroxyurea : Findings from the escort-HU cohort studies
Abstract Background: Hydroxyurea (HU) is a widely used therapy for sickle cell disease (SCD), reducing the frequency of vaso-occlusive crise...
Treatment-free remission outcomes in pediatric chronic myeloid leukemia: Second-generation TKIs vs. Imatinib–a real-world multicenter study from China
Abstract Background Studies have demonstrated that a subset of adult chronic myeloid leukemia (CML) patients achieving deep molecular respons...
Clinical prognostication in the SWOG 1826 randomized clinical trial of nivolumab-AVD versus brentuximab-AVD: Performance of the advanced-stage Hodgkin lymphoma international prognostic index (A-HIPI)
Abstract Background The most widely used prognostication tool in classical Hodgkin lymphoma (cHL) historically has been the International Pr...
Preclinical evaluation of SPK-8011QQ, an adeno-associated virus gene therapy for people with hemophilia A leveraging the dirloctocogene samoparvovec platform encoding an activated Protein C-resistant B-domain deleted factor VIII
Abstract Background: Gene therapies for hemophilia A (HA) offer the potential for durable factor (F)VIII expression as a curative treatment...
B-like natural killer cells related to the epstein-barr virus infection present an adaptive immune phenotype and stronger killing activity in lymphomas
Abstract Background: Natural killer (NK) cells play a profound role in the immune system, contributing to antitumor and...
The prognostic value of patient-reported fatigue for survival in patients with aggressive B-cell lymphomas treated with CAR T-cell therapy
Abstract Background Chimeric antigen receptor (CAR) T-cell therapy is a valuable treatment option for patients with aggressive B-cell lympho...
Rare but not forgotten, a case of evan's syndrome.
Abstract A 46-year-old woman with a history of sickle cell trait presented with several weeks of fatigue, nausea, vomiting, and shortness of...
Evaluation of greatwall kinase inhibition as a potential therapeutic strategy in CLL and DLBCL.
Abstract Background: Greatwall (GWL), also known as MASTL (microtubule-associated serine/threonine kinase-like), is an enzyme active during...
It's not yet time to abandon ruxolitinib in anemic myelofibrosis: Predictive factors of erythroid response to standard anemia-directed therapies combined with ruxolitinib
Abstract Background. Ruxolitinib (RUX), the first JAK1/2 inhibitor approved for the treatment of myelofibrosis (MF), has significantly impro...
Endogenous and therapeutic transport of activated protein c across the blood-retina barrier protects the retina
Abstract Introduction: Protein C (PC) deficiency is a devastating thrombophilia. Its most striking non-thrombotic consequences involve the e...
Oral azacitidine as maintenance therapy post allogeneic stem cell transplant in patients with myeloid malignancies
Abstract Background: Despite improvements in overall survival (OS) after allogeneic stem cell transplant (alloSCT) in patients with acute my...
Presenting features, treatment patterns and predictors of outcomes in AL amyloidosis at a tertirary care cancer centre
Abstract Introduction Light Chain (AL) amyloidosis is the most common form of systemic amyloidosis, characterized by the deposition of misfo...
The international diamond blackfan anemia syndrome cancer consortium: Preliminary results
Abstract Background: Diamond Blackfan anemia (DBA) syndrome is an inherited bone marrow failure syndrome characterized by red cell aplasia,...
Trial in progress: A Phase 2a Study of GI-102 (CD80/IL2v3) as a consolidation therapy in patients with relapsed/refractory diffuse large B-cell lymphoma following anti-CD19 chimeric antigen receptor T-cell therapy (CARNATION trial)
Abstract Background CAR T cell therapy has demonstrated improved outcomes for patients with relapsed/refractory diffuse large B-cell lymphom...
Rapid transformation from JAK2-positive PMF to acute leukemia: Therapeutic challenges and rare DIC in an aggressive disease course
Abstract Background: Primary myelofibrosis (PMF) is a BCR-ABL1-negative myeloproliferative neoplasm characterized by pro...
Prior bendamustine exposure does not compromise clinical outcomes of bispecific antibody therapy in patients with relapsed/refractory non-Hodgkin lymphoma: A cubic consortium analysis
Abstract Introduction Bendamustine (benda) has prolonged lymphotoxic effects, and recent benda exposure prior to apheresis negatively impact...
Pre-treatment circulating tumor DNA predicts survival of diffuse large B-cell lymphoma patients and allows genetic and biological evaluation
Abstract Introduction. Circulating tumor DNA (ctDNA) was identified as a powerful biomarker for treatment response evaluation and outcome pr...
Early reduction of BCR-ABL at 3 months predicts deeper molecular remission in pediatric CML
Abstract Background: Chronic myeloid leukemia (CML) is extremely rare in pediatric populations, and clinical features and therapeutic respons...
Characterizing thrombosis in acute promyelocytic leukemia: Real-world insights from the middle east
Abstract Background: During the early phase of acute promyelocytic leukemia (APL), patients face a high risk of coagulopathy, predominantly...
A phase I dose escalation and expansion trial of lyt-200 (a First-In-Class Anti-Galectin-9 Antibody) alone and in combination with venetoclax/HMA in Relapsed/Refractory AML/MDS
Abstract Background: LYT-200 is a fully human IgG4 monoclonal antibody targeting galectin-9 (Gal-9), a key mediator of oncogenesis and immun...
The role of ENO1 and chidamide in PTCL-NOS
Abstract Enolase (ENO1) is a key enzyme involved in glycolysis and plays an important role in various types of cancer. This study explored t...
Prospective real-world evaluation of SKY92 for risk stratification in multiple myeloma: Comparison with updated ims/IMWG criteria in the prommis study
Abstract Introduction: Accurate risk stratification in multiple myeloma (MM) is essential to guide treatment decisions and improve outcomes,...