Blood
Articles in this Issue
Age at diagnosis shapes stage and survival in diffuse large B-cell lymphoma: A 22-year, population-based study of 94,598 SEER patients
Abstract Background: Diffuse large B-cell lymphoma (DLBCL), the most common non-Hodgkin lymphoma, shows a sharp rise in...
Assessing the association between antiphospholipid syndrome and non-melanoma skin cancers: A case-control study on the role of a chronic inflammatory condition
Abstract Antiphospholipid Syndrome (APLS) is an autoimmune hematological disorder defined by antiphospholipid antibodies and a hypercoagulab...
Early weight gain predicts nutritional recovery in children with sickle cell anemia and severe acute malnutrition in Nigeria
Abstract Introduction Malnutrition in children with sickle cell anemia (SCA) is associated with higher rates of hospitalizations and early m...
Novel evidence shows that intracellular complement (complosome) expressed in hematopoietic stem cell progenitor cells regulates hematopoiesis at both the mitochondrial and cellular metabolism levels.
Abstract Background. The intracellular complement network (complosome) has been identified to regulate lymphocyte-mediated immune responses...
Diluting high yield hematopoietic stem cell apheresis for autologous transplantation results in high viability of fresh grafts beyond 72h
Abstract Background: Autologous Hematopoietic Cell Transplantation (HCT) remains a highly efficient therapy primarily for patients with Mult...
The impact of clonal hematopoiesis on CAR-T cell therapy outcomes: A single-center analysis
Abstract Background: Clonal hematopoiesis (CH), including both clonal hematopoiesis of indeterminate potential (CHIP, VAF ≥2%) and micro-clo...
Pediatric inspired (BFM) protocol in adolescent and young adults (AYA) with acute lymphoblastic leukemia (ALL) in India: Real‑world treatment timelines and impact of delays on survival
Abstract Pediatric-inspired regimens have improved outcomes in adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL). T...
Machine learning uncovers prognostically distinct myeloma cast nephropathy phenotypes not captured by standard risk stratification systems
Abstract BACKGROUND Myeloma cast nephropathy (MCN), a driver of renal failure in 10-15% of newly diagnosed multiple myeloma (NDMM), remains...
Peripheral blood-based single-cell and genomic profiling of hematopoietic stem and progenitor cells enables accurate diagnosis and risk stratification in myeloproliferative neoplasms
Abstract Diagnosing myeloproliferative neoplasms (MPNs) remains challenging due to overlapping clinical and morphological features, and reli...
Selinexor-based non-intensive chemotherapy regimens adjusted according to early responses achieve high early remission in newly diagnosed AML or MDS
Abstract Background Some newly diagnosed (ND) acute myeloid leukemia (AML) or higher-risk myelodysplastic syndrome (MDS) patients (pts) are...
Iron infusions in pregnant women are associated with comparable efficacy and safety compared to non-pregnant women
Abstract Background: Iron infusions in pregnant women who have iron deficiency anemia (IDA) have been shown to be effective, safe, and well-...
Cell intrinsic heme synthesis supports glycolysis for activation of naive CD4+ T cell
Abstract Revealing the mechanism by which naive CD4+ (nCD4+) T cells are activated is vital to understanding how acquired immunity is orches...
Real-world data on anti-BCMA CAR-T in Brazil: A single-center retrospective case series
Abstract Background: The treatment landscape for relapsed/refractory Multiple Myeloma (R/R MM) in Brazil is unique, with both BCMA CAR-T (ci...
Impact of chimeric antigen receptor (CAR) product cell phenotypes on clinical outcomes following treatment with obecabtagene autoleucel (obe-cel)
Abstract Background: The Phase Ib/II FELIX study (NCT04404660) evaluated obe-cel, a CD19-directed autologous CAR T-cell therapy with a fast...
Additional myelodysplasia-related genes mutations affected the clinical presentations and prognosis of patients with SRSF2/TET2 co-mutations
Abstract Background Myeloid neoplasms (MN) display marked clinical and molecular heterogeneity. The 2022 WHO and ICC cla...
Outcomes associated with mitigating venous thromboembolism risk in pregnant patients with sickle cell disease
Abstract Introduction: Sickle cell disease (SCD) is an inherited hematologic disorder affecting around 100,000 Americans. Venous thromboembo...
Management of chronic myeloid leukaemia (CML) during pregnancy: A systematic review of maternal and foetal outcomes
Abstract Introduction The introduction of tyrosine kinase inhibitors (TKIs) has transformed the treatment of Chronic Mye...
Disease status at initiation of blinatumomab and depth of response after cycle 1 are associated with survival in Philadelphia chromosome positive B cell acute lymphoblastic leukemia patients treated with blinatumomab and tyrosine kinase inhibitors
Abstract Introduction: Philadelphia chromosome positive B cell acute lymphoblastic leukemia (Ph+ B-ALL) was historically...
Cardiopulmonary complications during pregnancy as a risk factor for cesarean delivery in a two center, sickle cell disease pregnancy cohort
Abstract Introduction: Pregnancy is high risk in sickle cell disease (SCD) with increased risk of pre-term and cesarean delivery. Little is...
Ropeginterferon alfa-2b in essential thrombocythemia of all risk levels ineligible for standard cytoreduction: 12-month primary endpoint analysis from the ROP-ET phase 3 study
Abstract Introduction Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by elevated platelet counts, risk of vas...
Apixaban or rivaroxaban for extended anticoagulation in patients with venous thromboembolism: A post hoc analysis of the renove clinical trial
Abstract Background: Apixaban and rivaroxaban are approved for the initial and extended treatment of venous thromboembolism (VTE). Both drug...
Comparative effectiveness of CAR-T cell therapy vs. teclistamab in relapsed/refractory multiple myeloma: A real-world propensity-matched analysis revealing survival advantages and treatment disparities
Abstract Background: CAR-T cell therapy and bispecific antibodies (BsAbs) such as Teclistamab have expanded therapeutic...
Whole-genome analysis reveals shared early genetic alterations and subtype-specific immune evasion pathways in intravascular large B-cell lymphoma and immune-privileged large B-cell lymphoma
Abstract Introduction Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of aggressive lymphoma characterized by selective growt...
Beliefs about medicines and self-reported medication adherence in patients with primary immune thrombocytopenia: A cross-sectional Study in Greece
Abstract Introduction Patient medication adherence is essential for the effectiveness of therapeutic interventions. Patients' perceptions of...
Overall survival and event-free survival in bone marrow versus peripheral blood as stem cell source for hematopoietic stem cell transplant in children and adolescents with hematological malignancies.
Abstract IntroductionRelapse risk after stem cell transplantation (SCT) is a key concern in treating childhood acute lymphoblastic leukemia...