Blood
Articles in this Issue
Therapeutic trade-offs between ide-cel and cilta-cel in RRMM: A meta-analytic comparison of efficacy and adverse events
Abstract Background: Multiple myeloma (MM) is a hematologic malignancy characterized by the clonal proliferation of plasma cells in the bone...
DNA methylation instability as a biomarker to predict resistance or progression to advanced disease Phase following tyrosine kinase inhibitor therapy in chronic myeloid leukemia
Abstract Introduction DNA methylation occurs at defined CpG sites across the genome and plays a critical role in regulating gene expression....
Prognostic relevance of epigenetic regulation of drug pharmacology and myeloid genes in pediatric AML
Abstract Introduction: The dysregulation of DNA methylation in acute myeloid leukemia (AML) significantly changes the regulation and express...
Severe toxicities in survivors of pediatric and adolescent acute lymphoblastic lymphoma: A population-based study in Ontario, Canada
Abstract Cure rates for children, adolescents, and young adults with acute lymphoblastic leukemia (ALL) have improved dramatically and have...
Elevated TIM3 expression on bone marrow T cells drives immune dysfunction in early relapsed blood cancer after allogeneic hematopoietic stem cell transplantation
Abstract Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a curative option for hematologic malignancies,...
Real-world treatment patterns and outcomes in patients with myelofibrosis who presented with thrombocytopenia and anemia at initiation of pacritinib treatment
Abstract Background: The co-occurrence of thrombocytopenia and anemia (bicytopenia) in patients (pts) with myelofibrosis (MF) is a therapeut...
Low-dose post-transplant cyclophosphamide for GvHD prophylaxis in haploidentical stem cell transplantation: A systematic review of efficacy, toxicity, and survival outcomes
Abstract Background: Haploidentical allogeneic stem cell transplantation (haplo-SCT) has been a transformative option for patients lacking m...
Zip-code drug conjugates (ZDCs): Ctdna-guided therapy shows strong efficacy and low toxicity in vitro and In Vivo
Abstract Multiple myeloma (MM) is a malignancy marked by the clonal expansion of plasma cells. Despite therapeutic advances, MM remains incu...
Face validity of progressive rank criteria to identify high-utilizer sickle cell patients in an adult sickle cell disease medical home
Abstract Background Community-based case management within a sickle cell disease (SCD) medical home offers the potential to reduce costly em...
Meta-analysis confirms venetoclax plus decitabine as a frontline game-changer in elderly AML (Acute Myeloid Leukemia)
Abstract Background: Acute Myeloid Leukemia (AML) in elderly patients is characterized by poor clinical outcomes, limite...
Post-treatment loss of MMR vaccine immunity in multiple myeloma patients following autologous stem cell transplantation: A retrospective cohort analysis
Abstract Background Multiple myeloma (MM), a clonal plasma cell malignancy, accounts for approximately 10% of all hemato...
Tracking fellowship competitiveness in hematology-oncology: Insights from nrmp match data (2014–2025)
Abstract Background This study evaluates trends in Hematology-Oncology fellowship match outcomes from 2014 to 2025 using...
SOUNDTRACK-B: A phase 2 single-arm study to evaluate the efficacy and safety of surovatamig (AZD0486) in relapsed or refractory B-cell non-Hodgkin lymphoma
Abstract Background and Significance: Management of relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHL) is challenging. Surovat...
Patient outcomes for sickle cell disease with support staff-driven interventions: A scoping review
Abstract Background: Sickle cell disease (SCD) is a chronic condition characterized by progressive organ dysfunction and significant early m...
Evaluation of CAR-T access barriers in Washington and Alaska: A single-center experience prior to implementing program capacity expansion
Abstract Background: Chimeric antigen receptor T cell therapies (CAR-T), while transformative, are expensive, require specialty center treat...
Comparative analysis of prophylaxis with 1:1 ratio pdVWF/FVIII concentrate vs. recombinant VWF in type 3 von willebrand disease adults in the United States: Clinical and economic perspective
Abstract Background Prophylactic treatment with von Willebrand factor (VWF) concentrates is recommended for patients wit...
Ruxolitinib and cardiovascular outcomes among patients with myelofibrosis
Abstract Introduction: Myelofibrosis (MF) is an advanced phenotype of Philadelphia chromosome-negative myeloproliferative neoplasm (MPN) char...
Trial in progress: CAR-T (idecabtagene vicleucel) in advanced myeloma plus iberdomide or usual monitoring (The Alliance A062102 CADMIUM Study)
Abstract Background: Multiple myeloma (MM) remains incurable, though key advances such as chimeric antigen receptor T-cells (CAR-T) and immu...
Optimizing classical hematology referrals: Development and early evaluation of an enhanced referral intervention
Abstract Background Classical hematology has a shortage of providers, leading to extended wait times from the time of referral to the initia...
Autoimmune hemolytic anemia: An underrecognized contributor to anemia and hemolysis in babesiosis infection
Abstract Background: Babesiosis is a zoonotic illness transmitted by ticks and caused by intraerythrocytic protozoa belonging to the genus B...
Deep learning-based tumor microenvironment profiling predicts CAR-t efficacy and guides combinatorial immunotherapy in B-cell lymphoma
Abstract Introduction CAR-T cell therapy efficacy in B-cell lymphoma remains limited by treatment resistance. To address this fundamental ch...
A multi-site break through cancer pilot study testing the feasibility and safety of therapeutic intervention for patients with high-risk clonal cytopenia of undetermined significance (CCUS)
Abstract Background Clonal hematopoiesis (CH), the age-related clonal expansion of blood cells, is often caused by somatic mutations genes as...
Photodynamic immunotherapy using adu-S100-modified nanoparticles combined with icb to treat triple-negative breast cancer
Abstract Background Tumor immunotherapy is an important cancer treatment that stimulates or modulates the immune system to improve the intri...
Optimizing immunity to pneumococcus by vaccination with pneumococcal 13-valent conjugate vaccine before and after CD19-targeted CAR T cell immunotherapy
Abstract Background: Patients with relapsed or refractory B-cell non-Hodgkin's lymphoma undergoing CD19-targeted CAR T-cell therapy (CAR-T)...
A real-world study on first-line early switch to kpd regimen in the treatment of multiple myeloma patients with suboptimal induction efficacy or intolerance
Abstract Objective: To evaluate the efficacy and safety of early switch to the KPD regimen (carfilzomib, pomalidomide, dexamethasone) in mul...