Blood
Articles in this Issue
Thrombotic manifestations in GATA2 deficiency: A systematic review of frequency and clinical spectrum
Abstract Introduction: GATA2 deficiency is a rare autosomal dominant genetic disorder characterized by immunodeficiency, bone marrow failure...
Iron deficiency limits hydroxyurea-induced fetal hemoglobin and clinical efficacy in sickle cell disease
Abstract Background Hydroxyurea (HU) is a widely used therapy for sickle cell disease (SCD) patients. HU reduces the frequency of acute comp...
Clinical outcomes of first-line venetoclax-based regimens vs second-generation BTK inhibitors in CLL/SLL: A retrospective cohort study
Abstract INTRODUCTION: Targeted therapies have become the standard first-line treatment for patients with chronic lymphocytic leukemia (CLL/...
Bridging conventional and molecular cytogenetics: Evaluating concordance of karyotyping and FISH in pediatric B-ALL and implications for post-induction MRD assessment, experience from Pakistan
Abstract Background/Objectives Cytogenetic and molecular genetics play a crucial role in the diagnosis of B-lymphoblastic leukemia (B-ALL)....
The BRAIN initiative: Bettering radiology access to improve neuro-outcomes in sickle cell disease
Abstract Prior to age 20, 11% of children with sickle cell disease (SCD) will have a stroke without recommended preventive care, namely the...
Chemotherapy free ponatinib + asciminib achieves optimal disease controlpreallohsct in advanced – CML
Abstract Background. Progression of chronic myeloid leukemia (CML) to blast crisis (CMLBC) is associated with poor progn...
Hypomethylation agent improves late-stage megakaryocyte maturation in MDS
Abstract Thrombocytopenia affects a substantial proportion of patients with myelodysplastic syndrome (MDS). Mechanisms for aberrant thrombop...
High transplant conversion rates with gemcitabine, dexamethasone and carboplatin (GDP)-based therapy in Relapsed/Refractory lymphoma: A real-world experience
Abstract Background Relapsed & refractory (R/R) disease imposes significant morbidity and mortality on lymphoma pati...
Crosstalk between CEP72 germline polymorphism and NOTCH1 somatic mutations alters the sensitivity of leukemia cells and normal T cells to vincristine, influencing the prognosis of pediatric T-ALL
Abstract Background: Vincristine is one of the most important agents for pediatric acute lymphoblastic leukemia (ALL), but its extended use...
Thrombotic thrombocytopenic purpura after allogeneic hematopoietic cell transplantation: A rare but fatal complication.
Abstract Introduction Thrombotic microangiopathy (TMA) is a common and potentially fatal complication after allogeneic hematopoietic stem ce...
Improved survival with intermediate-intensity pediatric-inspired regimen and allo-HSCT in adults with ALL in a resource-limited setting
Abstract Introduction: Acute lymphoblastic leukemia (ALL) is associated with inferior overall survival (OS) and progression-free survival (P...
Discontinuation of targeted therapy in histiocytic neoplasms with durable response: A multicenter retrospective study
Abstract Introduction: Targeted therapy yields deep and durable response in histiocytic neoplasms.However, relapse rate following interrupti...
Integrating palliative care improves pain management and reduces length of stay in a comprehensive lifespan sickle cell center
Abstract Introduction: Sickle cell disease (SCD) is the most common monogenic disorder in the United States, affecting over 100,000 people (...
Novel BCR::ABL1 fusion alongside T315I reveals mechanism for dual ponatinib/asciminib resistance and proves sensitive to addition of axitinib
Abstract Despite significant progress in targeting the BCR::ABL1 kinase in chronic myeloid leukemia (CML), the emergence of therapeutic resi...
The venetoclax conundrum: Therapeutic drug monitoring of venetoclax: Correlation with response in Acute Myeloid Leukemia？
Abstract Background: Venetoclax (VEN) as a BCL-2 inhibitor, has shown promising results in treating adult acute myeloid leukemia (AML). Howe...
A post-marketing pharmacovigilance analysis of cardiotoxicities following chimeric antigen receptor T-cell therapy using the FDA adverse event reporting system
Abstract Background: Chimeric Antigen Receptor T-cell therapy (CAR-T) has revolutionized the treatment landscape of hematological cancers, i...
Loss of p53 enhances LMO2 induced transdifferentiation of B-cells to T-cell acute lymphoblastic leukemia
Abstract Transdifferentiation (TD) is a direct conversion of one cell type into another without passage through induced pluripotent stem cel...
Azacitidine (AZA) and donor lymphocyte infusion (DLI) is a viable salvage approach for chimerism-only relapse following allogeneic blood or marrow transplantation (BMT)
Abstract Background: Post-BMT relapse of myeloid malignancies is fraught with limited options for salvage. AZA-DLI is commonly used, but the...
Efficacy of combination immunotherapy of eltrombopag, ATG and cyclosporine in aplastic anaemia
Abstract Introduction: Aplastic anemia (AA) is a rare, life-threatening bone marrow failure disorder with annual prevalence of 0.5 to 6 case...
A predictive framework leveraging integration site profiling to stratify CAR-T response in Relapsed/Refractory multiple myeloma
Abstract Introduction Chimeric antigen receptor (CAR) T-cell therapy has revolutionized treatment for relapsed/refractory multiple myeloma (...
Amlsp model for AML survival prediction
Abstract Background: Acute myeloid leukemia (AML) is characterized by marked molecular heterogeneity, which critically dictate risk stratifi...
Multiple myeloma genetic alterations have distinct repertoires and prognostic implications in African and european ancestries
Abstract Introduction: Multiple Myeloma (MM) disproportionately affects Black individuals, where it is 2-3 times more prevalent than in Whit...
Immune remodeling enables sustained EBV clearance in B-cell and plasma cell malignancies after anti-CD19/BCMA CAR-T therapy: A post-hoc analysis
Abstract Background Epstein-Barr virus (EBV) reactivation has increasingly been recognized as a poor prognostic indicator, as it may progres...
Clearance of RAS pathway mutations prior to allogeneic transplant in Acute Myeloid Leukemia are associated with favorable overall and leukemia free survival
Abstract Background: The prognostic impact of RAS-pathway mutations (RASm) in acute myeloid leukemia (AML) on post-allogeneic stem cell tran...
Post-allogeneic hematopoietic cell transplantation outcomes are similar after hypomethylating agent/venetoclax and intensive, cytarabine-based remission induction for Acute Myeloid Leukemia when using standardized, contemporary transplant techniques
Abstract Introduction: Since the introduction of hypomethylating agent (HMA) and venetoclax combination therapy for acute myeloid leukemia (...