Blood
Articles in this Issue
Real-world (RW) treatment (Tx) patterns, factors associated with discontinuation and toxicity across covalent BTK inhibitors (cBTKis) in first-line (1L) tx of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL)
Abstract INTRODUCTION cBTKis have become a standard 1L therapy for CLL/SLL. While second-generation (2G) cBTKis, acalabrutinib (Acala) and za...
Prophylactic dexamethasone to reduce risk of cilta-cel associated immune effector cell delayed neurotoxicity
Abstract Introduction Cila-cel is associated with a 10-15% risk of delayed neurotoxicity (DNT) with rates of cranial nerve palsies (IEC-NP)...
Galectin-3 in host murine models lessens the severity of graft-versus-host disease by preserving intestinal stem cells irrespective of gut microbiota composition
Abstract Introduction The gut microbiome has been studied in preclinical inflammatory disease models. Dysbiosis, where normal gut bacteria ar...
Interim analysis after 3 months of AML patients treated with venetoclax + azacitidine – first effectiveness and safety data from the prospective real world vero study
Abstract INTRODUCTION In Italy, the combination of Venetoclax+Azacitidine (Ven/Aza) is approved, as the standard of care...
Identifying patients at risk of prolonged neutropenia and enhanced risk of complications during AZA-VEN induction for AML
Abstract Background: Prolonged neutropenia and infectious complications represent an important concern during the first induction cycle of az...
Generative AI–Powered clinical decision support in germline predisposition to myeloid neoplasms
Abstract Introduction The exploration of germline predispositions to myeloid neoplasms (MNs) has gained significant traction, particularly w...
Multiple HLA-loss clones are required for hematologic regeneration in immune aplastic anemia
Abstract Background In patients with immune aplastic anemia, hematopoietic stem cells deficient in specific HLA class I alleles can evade cy...
Menstruation-induced vaso-occlusive crisis in women with sickle cell disease
Abstract Introduction: Sickle cell disease (SCD) affects approximately 100,000 people in the United States. Pain is a well-known complicatio...
Single-cell multi-omics profiling reveals distinct patterns of clonal expansion and microenvironmental shifts associated with disease evolution in patients with Myelodysplastic Syndromes
Abstract Background. Myelodysplastic Syndromes (MDS) present an increased risk of progression to Acute Myeloid Leukemia (AML). The complex in...
Targeting BRD9 in KMT2A-rearranged Acute Myeloid Leukemia to circumvent MEN1 inhibitor resistance
Abstract Introduction: Acute myeloid leukemia (AML) with rearrangement of the KMT2A gene (KMT2Ar) is a blood malignancy with adverse clinica...
Vincristine-induced neuropathy: Long term follow-up of lymphoma survivors treated with CHOP or dose-adjusted EPOCH chemotherapy
Abstract Introduction: The incidence of Vincristine-induced neuropathy (VIN) occurs in up to 70% of non Hodgkin Lymphoma...
The complex dance of immunity: A review of secondary HLH in HIV (2000-2025)
Abstract Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening hyperinflammatory syndrome marked by severe i...
Characteristics, treatment outcomes, and prognostic analysis of 118 cases of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia
Abstract Background : Lymphoplasmacytic Lymphoma/Waldenström macroglobulinemia (LPL/WM) is a rare B-cell lymphoma consist of lymphocytes,lymp...
PyramIDH: A phase 3 study of ivosidenib monotherapy or azacitidine monotherapy in patients with mutant isocitrate dehydrogenase 1 myelodysplastic syndromes who have not received prior hypomethylating agent therapy
Abstract Background and Significance: Myelodysplastic syndromes (MDS) encompass a heterogeneous group of clonal myeloid disorders that prima...
Preliminary analysis of orelabrutinib combined with obinutuzumab in the treatment of marginal zone lymphoma (Orion Study)
Abstract Background: Marginal Zone Lymphoma (MZL) is a group of B-cell malignancies. Orelabrutinib (ORE), the first approved BTKi in China f...
An open-label Phase II trial of VDJ-001, a high-affinity IL-6R antagonist antibody, for the treatment of patients with idiopathic multicentric castleman disease
Abstract Interleukin-6 (IL-6) targeted therapy has been recommended as the most important treatment option for idiopathic Multicentric Castl...
Real-world use of Pola-R-CHP for untreated diffuse large B-cell lymphoma (DLBCL): A systematic literature review
Abstract Introduction: The phase III POLARIX study (NCT03274492) demonstrated the superiority of Polatuzumab vedotin (Pola) combined with ri...
Genetic deletion of vasoactive intestinal peptide (VIP) and PI3K signaling pathways impair CAR T cell function
Abstract Introduction: The clinical efficacy of chimeric antigen receptor (CAR) T cell therapy remains limited in solid tumors, with immunos...
Dynamic biomarker trajectories predict outcomes in AML-associated hemophagocytic lymphohistiocytosis
Abstract Introduction: Hemophagocytic lymphohistiocytosis (HLH) in adults with acute myeloid leukemia (AML) represents a devastating hyperin...
External validation of TTP-14: A novel machine learning model that improves rapid diagnosis of immune TTP
Abstract Background Due to the high mortality of immune thrombotic thrombocytopenic purpura (iTTP), rapid clinical evaluation and early inte...
Differentiation of human induced pluripotent stem cells expressing chimeric antigen receptors into distinct immune cells as an off-the-shelf strategy for tumor treatments
Abstract Immunotherapy based on T cells expressing Chimeric Antigen Receptor (CAR- T) has been shown to be a promising strategy for treating...
Correlative biomarker analyses of etentamig in patients with Relapsed/Refractory multiple myeloma (RRMM) at optimal dose support its potential to maximize T-cell activity with rapid and transient proinflammatory cytokine responses
Abstract Background Etentamig is a second-generation B-cell maturation antigen (BCMA) x CD3 bispecific antibody that has shown promising eff...
Single vs double cord blood transplantation: Improved engraftment with comparable efficacy
Abstract Background: For patients with hematologic malignancies, cord blood (CB) is a widely accepted source of hematopoietic stem cells. Du...
Heme oxygenase-1 facilitates immune evasion in diffuse large B-cell lymphoma by reprogramming tumor-associated macrophage polarization
Abstract Objective: Diffuse Large B-cell Lymphoma (DLBCL) is a hematologic malignancy characterized by the clonal expansion of myeloid proge...
Is PPM1D a potential driver of myeloid malignancy transformation in neuroendocrine tumor (NET) patients: An underrecognized malignant CHIPeRpetRaTor?
Abstract Background: Building on our prior work showing high baseline CHIP prevalence and cytopenias in NET patients (pt...