Blood
Articles in this Issue
Comprehensive genomic profiling refines diagnosis and reveals actionable fusions in myeloid malignancies: A real-world analysis
Abstract Background: Real-world data (RWD) provide essential insights into diagnostic and treatment patterns for myeloid...
Evaluating efficacy and safety of hydroxyurea and thalidomide for beta-thalassemia: A systematic review andmeta-analysis.
Abstract INTRODUCTION Therapeutic interventions such as hydroxyurea and thalidomide have individually demonstrated a reduction in transfusio...
Engineered iPSC-derived NK cells targeting the SIGLEC7-glyco-immune checkpoint improves anti-tumor activity in solid cancers
Abstract Sialylated glycans are typically over-expressed on the surface of tumor cells compared to normal cells. These glycans engage inhibi...
Prognostic impact of Mantle Cell Lymphoma frontline induction response assessments in the ECOG-ACRIN E1411 study of bendamustine-rituximab +/- bortezomib and maintenance with rituximab +/- lenalidomide
Abstract Background The prognostic utility of positron emission tomography/computer tomography (PET/CT) scan and bone marrow biopsy (BMB) as...
5-azacytidine treatment reshapes clonal structure and alters mutation-dependent splicing in MDS patients
Abstract Among molecular and cellular hallmarks of aging, changes in genetics, the epigenome and inflammation are now recognized as key medi...
From crisis to cure? thirteen years of real-world trends in acute promyelocytic leukemia outcomes in Qatar
Abstract Background: Acute promyelocytic leukemia (APL) is a distinct and highly curable subtype of acute myeloid leukemia. Despite the avai...
A high-dimensional spatiotemporal single-cell and 3D atlas of the bone marrow microenvironment during CML progression: Leukemia-driven vascular remodeling, immune dysregulation, and megakaryocyte abnormalities
Abstract The bone marrow microenvironment (BMME) critically regulates hematopoiesis and immune function. Disruptions in its cellular composi...
Single-cell transcriptomics reveals proliferative, immune-evasive, and bone marrow–independent transcriptional programs in extramedullary multiple myeloma.
Abstract Background Extramedullary disease (EMD) in multiple myeloma (MM) represents an aggressive phenotype with poor outcomes. We performed...
Factors associated with acute and chronic graft-versus-host disease after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis
Abstract Background: Graft-versus-host disease (GVHD) is a significant complication of allogeneic hematopoietic cell transplantation (allo-H...
Comparative analysis of ide-cel and cilta-cel in patients with Relapsed/Refractory multiple myeloma: A nationwide, retrospective, real-world analysis across Austria
Abstract Background: B-cell maturation antigen–directed CAR-T cells have revolutionized the therapeutic landscape of relapsed/refractory mul...
Combined FLT3 and EZH1/2 inhibition reduces LSCs and promotes myeloid differentiation in PDX models of AML
Abstract Activating mutations in FMS-like tyrosine kinase 3 (FLT3) are among the most frequently identified mutations in acute myeloid leuke...
Comparative efficacy and safety of bendamustine versus fludarabine and cyclophosphamide as lymphodepleting regimens for CAR-T therapy in hematological malignancies: A systematic review and meta-analysis
Abstract Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy has become an established treatment for acute lymphoblastic leukemia...
Adrenergic signaling and hematopoietic stem cell function in the bone marrow niche rely on peri-arteriolar NADPH oxidase (NOX) and connexin gap junctions.
Abstract Hematopoietic stem cell (HSC) activity is tightly regulated by the bone marrow (BM) microenvironment, often referred to as “niche”....
Mass spectrometry compared to serum electrophoresis and immunofixation to detect monoclonal proteins and therapeutic antibodies in plasma cell disorders
Abstract Background Serum protein electrophoresis (SPEP) and immunofixation (IFE) are the standard methods for detecting and monitoring mono...
Infection rates and mortality in multiple myeloma: Impact of blood counts and IgG levels over time
Abstract Background Infection is one of the leading causes of mortality in multiple myeloma (MM) due to disease-related...
Real-world pharmacovigilance of BCMA-targeted CAR-T therapy in refractory multiplemyeloma: A comparative analysis of idecabtagene vicleucel and ciltacabtagene autoleucel
Abstract Background: B-cell maturation antigen (BCMA)-directed CAR-T therapies have redefined care for relapsed and refractory multiple myelo...
High-throughput single-cell methylation resolves epigenetic states in hematopoietic differentiation and age-related clonal expansions
Abstract DNA methylation at CpG dinucleotides is a critical regulator of cell identity and epigenetic memory, and it becomes universally dis...
Characterization of pityriasis rubra pilaris with hematological malignancies: Paraneoplastic disease and targeted therapy reactions
Abstract Pityriasis rubra pilaris (PRP) is a chronic, inflammatory papulosquamous skin condition of poorly understood pathogenesis; fewer th...
Allele-dependent activity of promoters of genes SLC22A4 and SLC22A5 encoding imatinib transporters in chronic myeloid leukemia
Abstract Introduction In our previous studies, we identified an association between the regulatory SNP rs460089, located in the promoter of S...
Bayesian diagnostic test accuracy meta-analysis of ¹⁸F-FDG PET/CT for detecting Richter's transformation in chronic lymphocytic leukemia
Abstract Introduction: Richter's transformation (RT) occurs in approximately 8–10% of patients with chronic lymphocytic leukemia (CLL) and i...
Clonal architecture and dynamics of somatic evolution in aplastic anemia and paroxysmal nocturnal hemoglobinuria
Abstract Aplastic anemia (AA) is a life-threatening bone marrow failure driven by T-cell attack on hematopoietic stem and progenitor cells (...
Fixed-duration preemptive rituximab maintenance over two years in recurrent thrombotic thrombocytopenic purpura with low ADAMTS13: A single-center case series
Abstract Introduction: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a thrombotic microangiopathy (TMA) caused by severely r...
Integrated transcriptomic and proteomic analysis of clonal plasma cells from patients with AL amyloidosis
Abstract Systemic AL amyloidosis is a rare disease caused by the abnormal extracellular deposition of misfolded immunoglobulin light chain f...
Patient experience sub-study of a randomised UK multicentre Phase 2 trial of ASTX727 versus hydroxycarbamide/best supportive care in myelodysplastic (MDS)/myeloproliferative (MPN) overlap syndromes (AMMO)
Abstract Introduction MDS/MPN Overlap Syndromes are haematological neoplasms with overlapping features of myeloid dysplasia and proliferatio...
Different graft-vs-host disease prophylaxis strategy for allogeneic hematopoietic stem cell transplantation in adults with chronic active EBV infection
Abstract Background: Adult patients with chronic active Epstein-Barr virus (CAEBV) infection face a challenging prognosis. Increasing eviden...