Blood
Articles in this Issue
Early outcomes with a standardized admission order set for sickle cell crisis: A real-world single-institution retrospective review
Abstract Introduction: Sickle cell disease (SCD) is an inherited disorder affecting the beta-globin gene encoding the be...
Next-generation sequencing panel for hereditary erythrocytosis identifies genomic variants in over half of adults with otherwise unexplained erythrocytosis
Abstract Background: JAK2-unmutated erythrocytosis constitutes a spectrum of hereditary and acquired entities. We assessed the diagnostic yi...
Mitochondrial hyperactivity predicts chemotherapy relapse and venetoclax resistance in pediatric B-cell acute lymphoblastic leukemia
Abstract Background: Relapse remains the major cause of treatment failure and mortality in pediatric B-cell acute lymphoblastic leukemia (B-A...
Outcomes of myeloablative vs reduced and non-myeloablative conditioning in MRD-negative AML and ALL with ptcy-based GVHD prophylaxis
Abstract Introduction: The optimal conditioning intensity for patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (A...
Survival outcomes of multiple myeloma patients previously exposed to BCMA-targeted therapies in the honeur european network
Abstract Introduction: Survival rates for patients with multiple myeloma (MM) have recently improved, thanks to an increase in treatment opt...
Contextualising and tailoring standards-based audit (SBA) processes for sickle cell disease (SCD) care in Zambia: A pilot Study
Abstract Background Sickle Cell Disease (SCD) is the most common inherited haemoglobinopathy in the world, affecting mostly Sub-Saharan Afri...
Identification and functional characterization of a novel best-in-class anti-CD79b CAR T cell immunotherapy using a multidimensional screening strategy
Abstract Introduction: Chimeric antigen receptor T cell therapy targeting CD19 (CART19) has revolutionized the treatment of large B cell lym...
Trends in collecting health-related quality-of-life measures among hematology gene therapy clinical trials
Abstract Background: Health-related quality-of-life (HRQOL) is increasingly recognized as a key, patient-centered clinic...
Safety of myeloablative total marrow and lymphoid irradiation versus chemotherapy-based conditioning in adults with high-risk acute lymphoblastic leukemia in a limited resources setting
Abstract Introduction In patients with relapsed or refractory acute lymphoblastic leukemia (RR ALL), allogeneic hematopo...
Maintaining higher hemoglobin levels is associated with improved overall survival in Myelodysplastic Syndromes (MDS): A real-world retrospective analysis of electronic health records from a US community setting over the past 20 years
Abstract BACKGROUND Anemia with chronic ineffective erythropoiesis is the most common cytopenia in MDS and often require...
Impact of G-CSF in AML patients treated with venetoclax and azacitidine: A dataml registry study
Abstract Introduction The venetoclax-azacitidine (VEN-AZA) combination has become a standard treatment for AML in older patients (pts) or tho...
Exploring the spectrum of non-malignant complications in germline DDX41-associated hematologic disorders
Abstract First discovered by our group in 2015 Cancer Cell. 2015 May 11;27(5):658-701 in an index family with history of MDS/AML, DDX41 is m...
VACARME : Analysis of humoral protection at baseline and after vaccination in patients with refractory/relapsed lymphoma and myeloma treated with CD19 and BCMA CAR T-cells.
Abstract Introduction Introduction. CART-cell therapy targeting CD19 and B-cell maturation antigen (BCMA) has improved the prognosis of pati...
Macrophage CD38 overexpression drives primary platelet engraftment failure via paracrine suppression following allogeneic hematopoietic stem cell transplantation
Abstract Background: Post-transplant thrombocytopenia (PT) is a severe complication following hematopoietic stem cell transplantation (HSCT)...
ACCELERATE: A platform protocol to investigate post-transplant cyclophosphamide-based graft-versus-host disease prophylaxis in patients with hematologic malignancies undergoing mismatched unrelated donor peripheral blood stem cell transplantation
Abstract Background: Post-transplant cyclophosphamide (PTCy) has significantly improved the feasibility of mismatched unrelated donor (MMUD)...
Initial clinical data from the phase 1 study of DR-01, a non-fucosylated anti-CD94 antibody in patients with large granular lymphocytic leukemia
Abstract Introduction: Large granular lymphocytic leukemia (LGLL) is a chronic, incurable lymphoproliferative disorder of cytotoxic T (CD8)...
An update: Safety and efficacy of GPRC5D targeting CAR-T cell therapy in relapsed/refractory multiple myeloma patients
Abstract Background: B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapies have sho...
Continuous venetoclax for relapsed chronic lymphocytic leukemia (CLL) – characteristics and outcomes of long-term responders
Abstract Aim: Venetoclax was initially approved for continuous use in relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL), but t...
Low expression of TMSB10 in bone marrow in MDS patients with T cell large granular lymphocytic proliferation is associated with improved immune tolerance status of T cells and disease prognosis: Clinical data and single-cell sequencing analysis
Abstract Myelodysplastic syndromes/tumors (MDS) are a highly heterogeneous group of myeloid malignancies. It has been reported that 1.38%~20...
Real-world outcomes of immune checkpoint inhibitor rechallenge in patients with classical Hodgkin lymphoma
Abstract Background: Immune checkpoint inhibitors (ICIs) have been established as standard of care for patients with classical Hodgkin lymph...
Decoding Transgene Silencing from Stably Maintained AAV Genomes in Human Liver: Epigenetic Insights to Guide Next-Generation Vector Design
Abstract Introduction Gene therapy offers transformative potential for monogenic disorders, with adeno-associated virus vectors (AAVs) servi...
Optimal therapy for pediatric B-ALL in first relapse: Comparative effectiveness of blinatumomab to hematopoietic cell transplantation versus CD19 CAR T cell therapy
Abstract INTRODUCTION Outcomes for 1st relapse of pediatric B-lymphoblastic leukemia (B-ALL), especially high/intermediate-risk (HR/IR) relap...
Disparities in diagnosis and management of myelodysplastic syndromes in a brazilian cancer center: A comparison between public and private healthcare systems.
Abstract Introduction: Disparities in access to healthcare services are well-documented in Brazil, where a mixed public-private system often...
Fixed-duration versus continuous targeted treatment for previously untreated chronic lymphocytic leukemia: Results from the randomized CLL17 trial
Abstract Introduction Current treatment for chronic lymphocytic leukemia (CLL) follows two seminal paradigms: continuous Bruton tyrosine kin...
Integrating patient and clinician perspectives to advance R/R CLL care: Results of a multi-pronged global initiative
Abstract Background: The introduction of covalent BTK inhibitor (cBTKi) therapy and time-limited (TL) BCL2 inhibitor (BCL2i) regimens has es...