Blood
Articles in this Issue
Real-world treatment duration of ruxolitinib and use of transfusion among 2268 patients with myelofibrosis: An analysis of the Medicare fee-for-service claims database
Abstract Background: Ruxolitinib (RUX) is approved by the US Food and Drug Administration for the treatment of adults with intermediate- or...
Expanding access to haploidentical transplantation : Clinical feasibility of a centralized nationwide distribution model for fresh TCRα/β-depleted grafts in France
Abstract Introduction: TCRα/β and CD19 depletion is an in vitro graft engineering method developed for haploidentical hematopoietic stem cel...
SAT1, a novel target of SF3B1 K700E mutant in chronic lymphocytic leukemia, facilitates disease development via regulating T-cell function
Abstract BackgroundChronic lymphocytic leukemia (CLL) is the most common adult leukemia. Mutations in splicing factor 3b subunit 1 (SF3B1),...
Modeling germline DDX41 and/or CHEK2 mutations using patient-derived bone marrow Organoids
Abstract Germline mutations in DDX41 and CHEK2 are recurrently linked to myeloid malignancies, yet their early impact on human hematopoiesis...
Clinical impact of individualized care plans on management of acute pain in the emergency department for children and adults with sickle cell disease
Abstract Introduction: The American Society of Hematology and National Alliance of Sickle Cell Centers recommend individualized care plans (...
Potential biomarkers and mechanisms in central nervous system involvement of KMT2A rearranged b-ALL: Insights from Patient-derived xenograft models
Abstract Background: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, accounting for nearly 70% o...
The role of BCL-6 in HBV positive diffuse large B-cell lymphoma
Abstract In recent years, more and more studies have shown that HBV is closely related to DLBCL and is an important adverse prognostic facto...
Evaluating the july effect on sickle cell crisis hospitalizations: A national inpatient sample analysis from 2016–2022
Abstract Background: Sickle cell disease is a condition seen widely across the nation with acute sickle cell crisis bein...
Single-cell metabolic profiling of post-infusion CD22 and CD19/CD22 CAR T-cells reveals a shift toward amino acid–driven oxphos informing SLC-armored CAR design
Abstract Chimeric antigen receptor (CAR) T-cell therapies have revolutionized treatment for hematologic malignancies, yet many patients fail...
Revisiting erythroid response in the phase 3 BELIEVE trial of luspatercept in patients with transfusion-dependent β-thalassemia using real-world criteria
Abstract Introduction: In the phase 3 randomized, double blind, placebo-controlled BELIEVE trial (NCT02604433) in transfusion-dependent β-th...
PD-1 expression on richter syndrome tumor cells does not provide a growth advantage in murine or patient-derived xenograft models In Vivo
Abstract The immune checkpoint receptor Programmed cell death 1 (PD-1) is expressed by the neoplastic B cells in the majority of clonally-re...
Aldehyde dehydrogenase 2 plays a dispensable role in hematopoiesis in response to DNA damage
Abstract Endogenous formaldehyde is a highly reactive metabolite that can induce DNA damage beyond the capacity of repair pathways, posing a...
Mapping skeletal muscle mitochondrial oxidative phosphorylation (OXPHOS) in childhood acute lymphoblastic leukemia survivors using a novel technique oxcest MRI
Abstract Introduction. Mitochondrial oxidative phosphorylation (OXPHOS) is the primary energy pathway powering skeletal muscle activity and...
Interim analysis of efficacy and safety for ALLG MM25 (Viber-M): A phase I b/II study of venetoclax, iberdomide and dexamethasone for patients in first or second relapse of multiple myeloma with t(11;14)
Abstract Background: Translocation t(11;14) is seen in 20% of multiple myeloma (MM) patients at diagnosis. Cumulative evidence suggests that...
Efficacy and safety of fitusiran prophylaxis in people with haemophilia a or haemophilia B: A systematic review and meta-analysis
Abstract Background: Prophylaxis is the standard of care for people with severe hemophilia A or B to prevent bleeding, but the treatment bur...
Design and characterization of novel albumin-based oxygen carriers as an alternative to whole blood
Abstract Introduction: Whole blood (WB) transfusion is routinely exercised for resuscitation following hemorrhage, supplementation in anemic...
Inferior survival in black AML patients treated with intensive chemotherapy in ECOG-ACRIN clinical trials is independent of cytogenetic profiles
Abstract Background: Population registries and the Alliance co-operative group database have highlighted racial disparities in AML survival...
Upstream integration of implementation planning in clinical trials through the blood and marrow transplant clinical trials network
Abstract Background: Dissemination and implementation science (D+I) efforts often begin after clinical trial (CT) efficacy data are availabl...
Impact of episodes of acute chest syndrom on the cardiac remodeling in children and young adults with sicle cell disease.
Abstract CONTEXT Cardiac mortality is reported to be the 4th leading cause of death in French children with sickle cell disease (SCD) with a...
Incidence and molecular underpinnings of donor-cell derived neoplasm among spanish transplantation centers
Abstract Introduction After an allogeneic hematopoietic stem cell transplantation (allo-HSCT), a wide range of complications may occur. One...
From society committees to clinical care: Navigating the divide between platelet transfusion thresholds for lumbar puncture across specialties
Abstract Institutional generation and adoption of clinical practice guidelines of platelet transfusion thresholds for lumbar puncture (LP) p...
Novel machine learning (ML) and traditional statistical techniques in survival analysis of real-world data for allogeneic hematopoietic cell transplantation (HCT) consolidation in patients with acute lymphoblastic leukemia (ALL)
Abstract IntroductionConsolidative allogeneic hematopoietic cell transplantation (alloHCT) in acute lymphoblastic leukemia (ALL) is a potent...
Divergent trends in high BMI-associated NHL mortality: An analysis of the globalburden of disease database 1990-2021
Abstract Introduction: Non-Hodgkin lymphoma (NHL) represents one of the most prevalent hematologic malignancies globally...
Real-World Effectiveness and Resource Utilization of Red Blood Cell Exchange in Adult Sickle Cell Disease: a Nationwide Robust Analysis from 2017-2022
Abstract Background: Red blood cell exchange (RBCx) is a critical, guideline-recommended therapy for severe, life-threatening complications...
Extended aprepitant in control of delayed emesis during induction chemotherapy for acute myeloid leukaemia – an multicentric, investigator-initiated, open label randomized controlled trial
Abstract IntroductionThe management of chemotherapy induced nausea and vomiting (CINV) during intensive induction chemotherapy for acute mye...