Blood
Articles in this Issue
The predictive value of mosaic chromosomal alterations for lymphoid malignancies varies by monoclonal B-cell lymphocytosis status
Abstract Background Mosaic chromosomal alterations (mCAs) are large-scale somatic gains, losses, or copy-neutral loss of heterozygosity (CNLO...
Pseudo-thrombotic microangiopathy secondary to severe vitamin B12 deficiency: A case series
Abstract Background: Thrombotic microangiopathy (TMA) is a hematologic emergency classically associated with thrombotic...
The asns inhibitor asx-173 potentiates l-asparaginase anticancer activity
Abstract Background Cancer cells reprogram metabolic pathways to meet increased energy and biosynthetic demands. Among those pathways, eleva...
Targeting adss overcomes venetoclax resistance in TP53-mutated acute myeloid leukemia
Abstract Venetoclax (VEN), when combined with hypomethylating agents such as azacitidine (AZA), is a critical FDA-approved AML therapy for o...
Acute Myeloid Leukemia mortality in u.S. older adults: A 45-year nationwide analysis with forecasting through 2050
Abstract Background: Acute myeloid leukemia (AML) remains a highly fatal hematologic malignancy among older adults in the United States. Des...
Mosunetuzumab (Mosun) or glofitamab (Glofit) in combination with golcadomide (Golca) demonstrates a manageable safety profile and encouraging efficacy in patients with relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL)
Abstract Background: Mosun and Glofit, both CD20xCD3 T-cell engaging bispecific antibodies, have demonstrated high response rates and manage...
Deepening responses and MRD-conversion in a phase II fixed-duration consolidation trial of elranatamab post-idecabtagene vicleucel CAR-T cell therapy (EPIC) in relapsed or refractory multiple myeloma
Abstract Introduction: Depth of response after idecabtagene vicleucel (ide-cel) CAR-T cell therapy has been correlated with longer progressi...
Formalized transition interventions in adolescents and young adults with sickle cell disease: A study of a transition clinic
Abstract Background: In the US, adolescents and young adults with sickle cell disease (SCD) are vulnerable to increased mortality due to com...
A multicenter real-world analysis of combined chemotherapy followed by consolidative radiation versus chemotherapy alone in the management of early-stage Hodgkin lymphoma – the HODGKIN25 study
Abstract Intro Early-stage classical Hodgkin lymphoma (cHL) is a highly curable malignancy. Traditionally, patients (pts) have been treated w...
A tale of two lymphomas: A rare case of transformative post-transplant lymphoproliferative disorder
Abstract Post-transplant lymphoproliferative disorders (PTLD) are immunodeficiency-related lymphoid proliferations that arise in the setting...
Cytoplasmic but not nuclear cleaved gsdmd expression in live macrophages and DLBCL cells marks proinflammatory cognate interactions rather than pyroptosis and predicts better patient survival in DLBCL
Abstract Background: Pyroptosis is a form of programmed cell death characterized by cleavage of gasdermin (GSDM) family proteins that form p...
Aplastic anemia treatment in older adults in resource-limited settings: Can rabbit ATG bridge the gap?
Abstract Background The treatment of choice for aplastic anemia (AA) is triple immunosuppressive therapy with horse anti-thymocyte globulin...
Comparative safety and effectiveness of apixaban versus warfarin in antiphospholipid syndrome with chronic kidney disease: A real-world propensity-matched cohort study
Abstract Background: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent arterial and/or venous thrombosis...
Rethinking disparity in Acute Myeloid Leukemia, a new perspective in the Asian population
Abstract Introduction: Racial/ethnic disparities in acute myeloid leukemia (AML) have been increasingly recognized. However, data outside of...
Clonal hematopoiesis of indeterminate potential- a potential risk factor for GI malignancies
Abstract Introduction Clonal hematopoiesis of indeterminate potential (CHIP) occurs when a hematopoietic stem cell under...
Ruxolitinib for refractory immune effector cell enterocolitis following ciltacabtagene autoleucel CAR T-cell therapy for multiple myeloma
Abstract Immune effector cell-associated (IEC)-enterocolitis, characterized by substantial and prolonged diarrhea following B-cell maturatio...
Outcomes of mecom rearranged AML undergoing intensive chemotherapy in the NCRI AML17 and AML19 trials.
Abstract Introduction MECOM rearrangements (MECOM::r) account for just 1-2% of adult AML, their outcomes are extremely poor, with high rates...
Efficacy and safety of adjunctive eptifibatide or argatroban versus control for acute ischemic stroke: A systematic review and network meta-analysis of randomized control trials
Abstract Introduction: Acute ischemic stroke is a major cause of disability and mortality, with treatment mainly limited to intravenous alte...
Molecular correlates of response and survival with venetoclax plus hypomethylating agent in treatment-Naïve high-risk myelodysplastic syndrome
Abstract Introduction High-risk myelodysplastic syndrome (HR-MDS) remains therapeutically challenging and is associated with poor overall su...
Clinical and biological correlates of blast-transformed chronic myelomonocytic leukemia (CMML): A multicenter study of 493 paired cases at chronic phase and at blast transformation
Abstract Introduction Blast transformation (BT) in CMML occurs in 15-30% of patients (pts) with a median overall survival (OS) <6 mon...
Insights from a multicenter study on the outcomes of liver abscess after allogeneic hematopoietic stem cell transplantation
Abstract Introduction: Liver abscess (LA), a severe and potentially life-threatening infection, is characterized by the...
Development of a novel proteomic biomarker for cancer-associated thrombosis
Abstract Introduction Clinical risk assessment scores can help risk-stratify patients for cancer-associated thrombosis (CAT); however, their...
Defective mitophagy of CD4+T cells in ITP via NAD+/SIRT1 reduction
Abstract Introduction Immune thrombocytopenia (ITP), an acquired autoimmune disease, is characterized by immune-mediated platelet destructio...
High VGPR/CR rates with pirtobrutinib plus venetoclax in previously treated Waldenström macroglobulinemia: Results from a multicenter phase II study
Abstract Background: BTK inhibitors and BCL2 antagonists, as monotherapy, are highly active and well tolerated in Waldenström macroglobuline...
An echocardiography and ferritin-based screening model to optimise cardiac T2* MRI use for detecting myocardial iron overload in transfusion-dependent thalassemia patients
Abstract Background: Myocardial iron deposition drives heart failure in transfusion-dependent β-thalassemia major, yet cardiac T2* magnetic...