Blood
Articles in this Issue
Prevalence and outcomes of inherited and acquired thrombophilia in pediatric patients with venous thromboembolism: Findings from an institutional prospective inception cohort study
Abstract Background There has been a significant increase in pediatric VTE over the last two decades, particularly among hospitalized childr...
A novel loop-structured CD19/CD22 dual-targeting CAR-T therapy for patients with refractory/relapsed B-cell non-Hodgkin lymphoma
Abstract BackgroundCAR-T cell therapy has demonstrated significant efficacy in B-cell malignancies, but relapse due to target antigen loss r...
Independent, international validation of the unsupervised harmony classification of Acute Myeloid Leukemia
Abstract Introduction: In adults, acute myeloid leukemia (AML) is the most frequently diagnosed acute leukemia, yet with heterogeneous biolo...
Long-read RNA sequencing of first multiple myeloma patient cohort reveals landscape of variant expression in newly diagnosed patients from the UKMRA RADAR trial
Abstract Introduction Multiple myeloma has a complex transcriptomic landscape with gene mutations, fusions, and spliced...
De novo glycosylation of MHC class I in platelets
Abstract Whether platelets can intracellularly de novo glycosylate proteins and how this affects platelet functions remains largely unknown....
In-hospital outcomes of patients admitted due to first-time acute chest syndrome with preexisting pulmonary embolism: A nationwide analysis 2016-2022
Abstract Background: Acute chest syndrome (ACS) is a well-known complication in sickle cell disease with significant mor...
Real-world comparison of thrombotic events in patients with Myelodysplastic Syndromes treated with luspatercept versus erythropoietin-stimulating agents using trinetx database
Abstract Background: Luspatercept, an erythroid maturation agent, has shown efficacy in improving anemia in both β-thalassemia and lower-ris...
Long-term projections of multiple myeloma mortality in the United States(2024-2040).: A time-series analysis stratified by sex, race, and geography
Abstract Background:Multiple Myeloma remains as a hematologic malignancy with significant mortality burden and persistent demographic dispar...
Clonal timing of FLT3-ITD dictates evolutionary trajectory and phenotypic heterogeneity in acute myeloid leukemia
Abstract Acute myeloid leukemia (AML) progresses through the sequential accumulation of somatic mutations, with signaling transducer mutatio...
Metabolism-focused CRISPR screen in B cell tumor identifies sphingolipid metabolism promotes resistance to CAR-T cell therapy
Abstract Significance Chimeric antigen receptor (CAR) T cell therapy has revolutionized the management of relapsed/refractory B-cell acute l...
Effect of immunoglobulin-replacement therapy on the incidence of severe infections in patients with chronic lymphocytic leukemia
Abstract Introduction: Patients with chronic lymphocytic leukemia (CLL) are at increased risk of secondary hypogammaglobulinemia (HGG), whic...
Revolutionizing hematology/oncology education through visual storytelling and gamification for internal medicine residents
Abstract Introduction: Hematology/oncology (heme/onc) is an often-overlooked specialty among internal medicine didactic curricula. In one re...
Bridging the gap: Global caregiver perspectives on awareness, motivators, and barriers to clinical trial participation in sickle cell disease
Abstract ”≥Background: The generation of robust and widely applicable data from clinical trials for sickle cell disease (SCD) depends on rec...
Investigation of predictive markers of disease complications in children with sickle cell disease: Preliminary findings from a multicenter prospective inception cohort study
Abstract Background: Sickle cell disease (SCD) is a multi-system, life-threatening disorder that leads to a wide spectrum of clinical compli...
First report of the GIMEMA INO-first multicenter observational study analyzing infective and non-infective complications in patients with relapsed or refractory B-cell acute lymphoblastic leukemia treated with inotuzumab ozogamicin.
Abstract INTRODUCTION. Based on the results of the phase III study INO-VATE, Inotuzumab ozogamicin (INO) has been approved as single agent f...
Temporal trends and demographic patterns in Hodgkin and non-Hodgkin lymphoma mortality among u.s. adults: A CDC wonder study
Abstract BACKGROUND: Hodgkin Lymphoma (HL) and non-Hodgkin lymphoma (NHL) are distinct malignancies that affect the lymphatic system, exhibi...
Low serum IgG at apheresis predicts delayed humoral immune reconstitution and increased risk of infections after CD19 CAR T-cell therapy for B-cell lymphoma
Abstract Background: Infections account for approximately half of non-relapse mortality following CAR T-cell therapy. Most infections occur...
Association between sars-cov-2 infection, COVID-19 vaccines and immune thrombocytopenia in adults. a nationwide population-based study in France.
Abstract Introduction: Early in the pandemic and the vaccination campaign, cases of immune thrombocytopenia (ITP) occurring after SARS-CoV-2...
Integrated multiomics identifies inhibitors of apoptosis (IAPs) and death-inducing signaling complex (DISC) components as novel vulnerabilities to overcome immune evasion in TP53-inactivated Acute Myeloid Leukemia
Abstract TP53-inactivated (TP53-mutant or deficient) acute myeloid leukemia (AML) is a biologically and clinically aggressive subtype associ...
T-cell engaging bispecific antibody shows potent MRD negativity with variable remission and survival outcomes: A bayesian meta-analysis of randomized controlled trials
Abstract Introduction B-cell acute lymphoblastic leukemia (B-ALL) remains a challenging malignancy, particularly in relapsed/refractory (R/R...
Distinct mTOR- and CDK1-regulated translation circuits sustain FLT3-mutated AML survival under therapy
Abstract Background Previously, we demonstrated that bone marrow stromal factors protect FLT3-mutant AML cells from FLT3...
Association between adolescent and young adult (AYA) age, acuity of illness at diagnosis, and clinical trial enrollment among patients with hematologic malignancies at a pediatric center
Abstract Background: Adolescent and young adult (AYA) patients with hematologic malignancies have inferior disease-free and overall survival...
Real life study of ivosidenib in either monotherapy or combined with azacytidine for first line mutant IDH1 AML: A study from the french AML intergroup ALFA/filo
Abstract Background: IDH1 mutations are found in 6-10% of acute myeloid leukemia (AML) cases. Ivosidenib (IVO), an oral mIDH1 inhibitor, is...
Fixed-duration teclistamab and talquetamab for frail patients with newly diagnosed multiple myeloma: The EMN37 fitfix study
Abstract Background and Significance . Novel treatments have considerably improved survival of transplant-ineligible patients with newly diag...
Renal responses in a phase 1/2 study of at-02, a novel pan-amyloid depleter ig fusion protein for the treatment of patients with AL amyloidosis
Abstract Introduction AT-02 is a humanized, recombinant IgG1 monoclonal antibody fusion protein containing a peptide tha...