Blood
Articles in this Issue
Revisiting accessible therapies for the management of Myelodysplastic Syndromes: A retrospective analysis of danazole, nandrolone or both.
Abstract “Revisiting accessible therapies for the management of myelodysplastic syndromes: a retrospective analysis of danazole, nandrolone...
IFNγ-driven MHC class II expression by intestinal epithelial cells dictates local cytolytic Th1 cell differentiation and intestinal stem cell loss
Abstract Allogeneic hematopoietic stem cell / bone marrow transplantation (hereafter BMT) is a curative therapy for malignant and non-malign...
Aplastic anemia mortality in the United States (1999–2023): Trends, disparities, and public health implications
Abstract Background: Aplastic anemia is a rare, life-threatening hematological disorder characterized by bone marrow failure and pancytopeni...
CAR-T with ICOS costimulation lacks therapeutic efficacy in patient due to strong trogocytosis and failure of expansion
Abstract Background CAR-T cell therapy targeting B-cell antigens has become an established strategy for relapsed hematol...
Understanding the essential thrombocythemia diagnosis journey, treatment experience, disease burden, and unmet need: Insights from a qualitative interview study with patients in the United States
Abstract Background: Essential thrombocythemia (ET) is a rare, chronic myeloproliferative neoplasm characterized by sustained elevated plate...
Latency between detectable low-level measurable residual disease (MRD) by next-generation sequencing and overt relapse following flow cytometry MRD-negative remission in patients with acute lymphoblastic leukemia: Implications for the optimal frequency of MRD monitoring
Abstract Background: In patients (pts) with acute lymphoblastic leukemia (ALL), MRD by next-generation sequencing (NGS) for IG/TR has become...
Prognostic utility of myocardial work indices and biomarkers for identifying anthraquinone induced cardiotoxicity in hematopoietic stem cell transplantation
Abstract High-dose chemotherapy combined with autologous hematopoietic stem cell transplantation (auto-HSCT) remains a critical treatment mo...
Orelabrutinib plus anti-PD-1 antibody and fotemustine for newly diagnosed primary central nervous system lymphoma: Phase I/II results
Abstract Background:Primary central nervous system lymphoma (PCNSL) is a rare and aggressive subtype of diffuse large B-cell lymphoma (DLBCL...
Characteristics and outcomes of pediatric hematopoietic stem cell transplantation-associated thrombotic microangiopathy: A retrospective single-center analysis
Abstract Background: Transplant-associated thrombotic microangiopathy (TA-TMA) is a heterogenous and life-threatening systemic complication...
The 2-year efficacy and safety of iptacopan monotherapy in patients with paroxysmal nocturnal hemoglobinuria with a history of aplastic anemia on concomitant immunosuppressive therapy who entered the roll-over extension program
Abstract Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, life-threatening disease characterized by complement-mediated he...
SGR-1505, a potent and selective MALT1 inhibitor with preliminary efficacy in BTKi exposed Waldenström macroglobulinemia (WM) and “double-exposed” CLL/SLL
Abstract Background: MALT1, a core subunit of the CBM complex (CARD11-BCL10-MALT1), plays an essential role in the NF-kB...
KIR3DL2-directed CAR T cell therapy for T cell malignancies
Abstract Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment landscape for B cell malignancies and multiple myeloma...
Integrative clinical and molecular analysis of outcome in elderly African ancestry Acute Myeloid Leukemia
Abstract Introduction: African Ancestry (AA) mediates inferior overall survival (OS) in Acute Myeloid Leukemia (AML), a feature highlighted...
ADAMTS13 variant (R1206K) exhibits increased VWF-cleaving activity and inhibition of thrombus formation under flow
Abstract Background: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy, caused by a severe deficien...
Final analysis of the evaluation of safety and efficacy of denosumab in patients with multiple myeloma and severe renal impairment: An IMWG bone subcommittee study
Abstract Background Multiple myeloma (MM) patients often develop bone disease, predisposing them to skeletal-related events (SREs). Renal im...
Treatment selection and functional outcomes in treatment-related acute myeloid leukemia (tAML) and AML with myelodysplasia-related changes (MRC): A multicenter prospective cohort study
Abstract Introduction: Liposomal encapsulated daunorubicin/cytarabine (L-dauno/ara-C) is FDA approved for adults with tAML and AML MRC based...
Disparities related to myelofibrosis: A retrospective analysis of US mortality data
Abstract Background Myelofibrosis (MF) is a rare clonal myeloproliferative neoplasm characterized by progressive bone ma...
Diagnostic test accuracy of serum ferritin and prevalence of iron deficiency in pregnant and menstruating individuals: A systematic review and meta analysis
Abstract Background Serum ferritin is widely used to diagnose iron deficiency (ID) with or without anemia due to its correlation with iron s...
The contemporary adolescent and young adult sickle cell population in Malawi
Abstract Sickle cell disease (SCD) is one of the most common inherited red blood cell disorders worldwide, with the majority of affected bir...
Atypical HUS: Diagnostic challenge and therapeutic success with eculizumab
Abstract Background: Atypical Hemolytic Uremic Syndrome (aHUS) remains a diagnostic challenge as it shares overlapping features of Thromboti...
A retrospective cross-sectional study to investigate femoral head avascular necrosis in sickle cell disease in Türkiye
Abstract Introduction: Sickle cell disease (SCD) is one of the most prevalent hemoglobinopathies worldwide. This autosomal recessive disorde...
Age-related differences in outcomes and treatment patterns of iron deficiency anemia in patient's with crohn's disease
Abstract Introduction Iron Deficiency Anemia (IDA) is a common extraintestinal manifestation of Crohn's Disease (CD) with reported prevalenc...
Developing a protocol for bloodless medicine patients undergoing transfusion-free kidney transplantation
Abstract Bloodless medicine patients, including Jehovah's Witnesses (JW), have provided a natural case study for examining how adjuvant ther...
A real-world analysis of primary mediastinal large B-cell lymphoma: A single center study in China
Abstract Background Primary mediastinal large B-cell lymphoma (PMBCL) is a unique subtype of lymphoma, and the optimal t...
Disrupting CXCL12-DPP4-GPC3 axis redistributes leukemia stem cells and confines AML cells within bone marrow niche
Abstract Background: Acute myeloid leukemia (AML) is sustained by a rare population of leukemic stem cells (LSCs) that reside within protect...