Blood
Articles in this Issue
Early time-to-relapse as a predictor of survival in mature T-cell/NK-cell lymphomas: Results from the PETAL consortium
Abstract INTRODUCTION We and others have demonstrated that patients with refractory nodal mature T-Cell lymphomas (nMTCL) have worse overall...
Real world experience of anakinra for the treatment of immune effector cell-associated neurotoxicity syndrome in large B-cell lymphoma
Abstract Background Anakinra, an IL-1 receptor antagonist approved for rheumatologic conditions, has been increasingly used off-label as a c...
Real-world treatment patterns and outcomes in patients with CLL and cardiovascular comorbidities: Interim analysis of the multicenter study conducted by eric.
Abstract Introduction Management of chronic lymphocytic leukemia (CLL) has advanced significantly over the past decade with the introduction...
Determining sensitivity to FLT3 inhibitors prior to therapy in FLT3 mutant acute myelogenous leukemia
Abstract INTRODUCTION: FLT3 mutations occur in ~30% of Acute Myelogenous Leukemia (AML) cases and while FLT3 inhibitors (FLT3i) have improved...
Clinical characteristics and molecular profiling of SF3B1-mutated myelodysplastic syndrome (MDS) in a real-world practice
Abstract Introduction SF3B1-mutated myelodysplastic syndrome (MDS) is now recognized as a distinct subtype in the latest World Health Organi...
The cachexia hematologic severity score (CHeSS): Use of a laboratory-based tool to predict survival and mutation-associated wasting in Acute Myeloid Leukemia and myelodysplastic syndrome
Abstract Introduction: Cachexia, marked by inflammation-driven losses in nutritional status, muscle mass, and fat tissue is known to lead to...
Evaluating reversal strategies for long-acting factor XI antibodies: RFVIIa®, FEIBA®, Kcentra®, novel FXI mutants, and an anti-idiotypic antibody
Abstract Background: Factor XI (FXI) and activated FXI (FXIa) inhibitor antibodies are emerging antithrombotic therapies due to their lower...
Prevalence and factors associated with acute transfusion reactions among patients receiving blood transfusions in regional referral hospitals in dar es salaam, Tanzania
Abstract Background: Blood transfusion is a lifesaving procedure, essential in the management of various medical and surgical conditions incl...
Selinexor combined with pegaspargase and dexamethasone, followed by radiotherapy, for newly diagnosed stage I–II natural killer/T-cell lymphoma: A multicenter, single-arm, Phase I/II study
Abstract Background：Our center's DDGP regimen has significantly improved the overall prognosis of natural killer/T cell lymphoma (NKTCL). N...
Hypermethylation of the ribosomal DNA coding sequence and disordered transcription factor binding as hallmarks of acute myeloid leukemia
Abstract Introduction: Ribosomal DNA (rDNA) encodes ribosomal RNA (rRNA), which undergoes processing to become ribosomes. Although rDNA dysr...
Dual transfusion independence and spleen volume reduction is associated with overall survival in patients with myelofibrosis treated with momelotinib: Post hoc analyses of SIMPLIFY-1 and MOMENTUM
Abstract Introduction: Myelofibrosis (MF) is a progressive, life-limiting hematologic malignancy characterized by splenomegaly, anemia, and...
CD47-blockade induces programmed necroptosis and complements the effects of BCL-2 inhibition in lymphoid malignancies
Abstract Introduction: Immune checkpoint blockade of CD47, a macrophage checkpoint protein that serves as a “don't-eat-me” signal on cancer...
Influenza A-triggered complement-mediated aHUS and high-grade block in a young adult: A case report
Abstract Background: Influenza infection is an uncommon precipitant of thrombotic microangiopathy (TMA) and an even rarer cause of transient...
Prevalence and characteristics of hepatotoxicity following asparaginase in adolescent and young adult acute lymphoblastic leukemia
Abstract Introduction Asparaginase-induced hepatotoxicity (AIH) is well recognized and occurs to some degree in the majority of patients wit...
Morbidity and mortality in 128 otherwise healthy Canadian children with severe iron deficiency anemia in the setting of ongoing bottle use and excessive cow's milk intake: A massive preventable problem demanding action
Abstract Introduction: Iron deficiency (ID) is the most common nutritional deficiency in the world, and an estimated 10%...
Dismantling systemic barriers in sickle cell disease care: Design and rationale of a municipal public health initiative in New York City
Abstract Introduction In response to systemic failures in sickle cell disease (SCD) care and sustained community advocac...
ALACRITY: A phase 1b/2 study of AZD0120 (BCMA/CD19 CAR-T cell therapy) in participants with relapsed or refractory light chain amyloidosis (AL)
Abstract Background Light chain amyloidosis (AL) is a rare, progressive plasma cell (PC) disorder marked by misfolding and organ deposition...
High-affinity PD-1-CD28 switch receptor enhances sustained antitumor activity of CAR-T cells in both lymphoma and ewing sarcoma.
Abstract Background: Although CAR-T cell therapy has revolutionized the treatment of hematologic malignancies, durable responses remain limi...
Plasmacytoid dendritic cell in a setting of acute myeloid leukaemia: A single-center case series from tertiary cancer hospital
Abstract Background: Acute myeloid leukemia (AML) exhibiting mature plasmacytoid dendritic cell (PDC)-like immunophenotype or plasmacytoid d...
Integrated genomic analysis identifies polo-like kinase 4 (PLK4) as a key regulator of chromosomal stability and growth in multiple myeloma
Abstract Background and Aims: Genomic instability, a prominent feature of cancer and precancerous conditions, leads to constant acquisition...
Chronic myelogenous leukemia: A real-world experience from a Los Angeles county safety net hospital
Abstract BACKGROUND Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromos...
A multicenter real-world study on response and survival in older patients with acute myeloid leukemia treated with intensive chemotherapy versus VEN/HMA by 2022 and 2024 ELN risk stratifications: An analysis from the MARROW consortium
Abstract INTRODUCTION Median age at diagnosis for acute myeloid leukemia (AML) in the U.S. is 69 years (yrs), with a dismal 5-yr overall sur...
Profile of NDMM patients who remain progression free at 10 years treated with RVD induction and risk adapted maintenance
Abstract Introduction: Multiple myeloma remains incurable despite treatment advances that have significantly improved progression-free survi...
OL-101, a BCMA/GPRC5D dual-targeting autologous CAR-T for relapsed/ refractory multiple myeloma (R/R MM): Results from a Phase I study
Abstract Background: BCMA- or GPRC5D-targeting agents are becoming the mainstay for treating R/R MM. However, resistance eventually develops...
Efficacy and safety of polatuzumab vedotin-based regimens for elderly/frail DLBCL patients: A real-world study
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma subtype, with incidence rising progressive...