Blood
Articles in this Issue
Epidemiologic insights into early-onset myelodysplastic syndrome: A longitudinal SEER analysis (2000-2022)
Abstract Background: Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders marked by ineffective hematopoiesis and peripheral c...
Phase 2 Study of polatuzumab vedotin, zanubrutinib and rituximab (Pola-ZR) in untreated elderly and frail DLBCL patients: Molecular features and follow-up updates
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is most diagnosed among patients aged over 65 years old, however, the 5-year ov...
Suicide risk management protocol (SRMP) for presence trial in adolescents and young adults (AYAs) living with sickle cell disease (SCD) and chronic pain
Abstract Background: In adolescent and young adults (AYA) with sickle cell disease (SCD) seen for routine clinical care, up to 11% may endor...
Relapsed diffuse large B-cell lymphoma is shaped by molecular subtypes and genomic alterations
Abstract Introduction: Newly diagnosed (ND) diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous disease that includes at le...
Transferrin and protection from thrombosis in sickle cell disease
Abstract Introduction: Transferrin is responsible for safe iron transport in the blood and iron delivery to cells through transferrin recept...
The durability of consolidative transplant in mediastinal gray zone lymphoma, a single institution retrospective
Abstract Introduction: Mediastinal gray zone lymphoma (MGZL) is a rare lymphoma with features intermediate between classical Hodgkin lymphom...
Dual epigenetic modulation with obinutuzumab/liposomal mitoxantrone in refractory or Relapsed Diffuse large B-cell lymphoma patients post-salvage therapy: A phase II study
Abstract Background: Patients with refractory or relapsed (R/R) diffuse large B-cell lymphoma (DLBCL) who had failed salvage therapy have an...
Oral chronic graft-versus-host disease (cGVHD) as a potential clinical marker of the graft-versus-leukemia (GVL) effect in allogeneic hematopoietic stem cell transplantation: A prospective single-center study
Abstract Background: Allogeneic stem cell transplantation (HSCT) is a well-established and life-saving therapeutic procedure for many patien...
Infection risk factors and burden in patients treated with T-cell engaging bispecific antibodies for relapsed B-cell lymphoma and multiple myeloma
Abstract Background T-cell engaging bispecific antibodies (BsAbs) are increasingly utilized in patients with relapsed/re...
Delivery of HFE mRNA by lipid nanoparticles corrects iron parameters and BMP responsiveness in murine hereditary hemochromatosis
Abstract Introduction: Disease-causing mutations in HFE lead to inappropriately low levels of the hepatic iron regulatory hormone hepcidin,...
Real-world analysis of infections after bispecific antibodies targeting anti-B-cell maturation antigen (BCMA) and protective impact of intravenous immunoglobulin (IVIG) in patients with multiple myeloma
Abstract Introduction: Elranatamab and teclistamab are bispecific antibodies (BsAb) directed against B-cell maturation a...
Impact of obstructive sleep apnea on hospitalized patients with polycythemia vera
Abstract Background: Polycythemia vera (PV), the most common myeloproliferative neoplasm, is characterized by erythrocytosis and often compl...
Early recognition and optimized management of tafro syndrome: A 10-year experience from a single center in China
Abstract Background: TAFRO syndrome (Thrombocytopenia, Anasarca/serositis, Fever, Renal impairment, Organomegaly) is a rare systemic disorde...
Efficacy and mechanism of BTK degrader nx-5948 in secondary hemophagocytic lymphohistiocytosis
Abstract Background: Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory condition marked by fever, cytopenia, hepatosple...
Orelabrutinib plus bendamustine-rituximab (OBR) Versus Bendamustine-rituximab (BR) in transplant-ineligible, intermediate- to high-risk Mantle Cell Lymphoma (MCL)
Abstract Background: Mantle cell lymphoma (MCL) is an aggressive and incurable B-cell lymphoma. While chemoimmunotherapy remains the standard...
Somatic ASXL1 mutations in chronic myelomonocytic leukemia result in loss of imprinting control and overexpression of DLK1 through deregulation of DNA methylation
Abstract Introduction: Protein truncating somatic ASXL1 mutations in CMML are associated with high-risk features and poor outcomes. We have...
Prevalence and significance of cytoses in clonal hematpoiesis
Abstract Introduction Clonal hematopoiesis (CH) is the age-related clonal expansion of hematopoietic progenitor cells, often caused by mutat...
Enhanced antileukemic activity of momelotinib in combination with venetoclax and azacitidine compared to gilteritinib-based combination
Abstract Acute myeloid leukemia (AML) is highly heterogeneous and the most common form of acute leukemia in adults. Despite extensive genomi...
Frontline treatment of sonrotoclax (BGB-11417) and zanubrutinib for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) demonstrates high undetectable minimal residual disease (uMRD) rates with favorable tolerability: Updated data from BGB-11417-101, an ongoing phase 1/1b study
Abstract Introduction: Frontline CLL/SLL treatments with venetoclax and a Bruton tyrosine kinase (BTK) inhibitor have emerged as important th...
Clinico-pathological profile and treatment patterns of immune mediated aplastic anemia in resource constrained settings – an analysis from the aplastic anemia registry of India
Abstract Introduction: The Aplastic Anemia Registry of India was initiated by a group of hematologists representing major institutions in th...
Liposomal mitoxantrone demonstrates superiority to traditional mitoxantrone in the treatment of AML
Abstract Background Acute myeloid leukemia (AML), a heterogeneous hematologic malignancy with poor prognosis, faces significant therapeutic...
Vδ2 unconventional T cells in the donor graft are associated with improved overall survival after unrelated donor allo-HCT for AML and MDS: An analysis from the DKMS and NMDP graft composition study
Abstract Introduction We have established an international collaboration between the DKMS (Germany) and the NMDP (USA) to characterize more...
First results of aponermin(Apo) improving teclistamab (tec)/talquetamab (tal) in patients (pts) with Relapsed/Refractory multiple myeloma (RRMM)
Abstract Background: Tec, a BCMA-directed bispecific antibody (Tal, another bispecific antibody targeting GPRC5D), has shown promising effic...
Prevalence and timing of iron deficiency among youth with sickle cell disease receiving chronic transfusions
Abstract Background Sickle cell disease (SCD) is a hereditary hemoglobinopathy affecting approximately 100,000 individ...
A randomized phase 2 Trial of romiplostim N01 versus recombinant human thrombopoietin for promoting platelet engraftment after allogeneic hematopoietic stem cell transplantation
Abstract Background and Significance: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) offers curative potential for hematolog...