Emerging biomarkers for CD3×CD20 bispecific antibodies in lymphoma
Abstract
Abstract Novel CD3×CD20 bispecific antibody (BsAb) immunotherapies have entered the armamentarium for follicular lymphoma and diffuse large B-cell lymphoma based on accelerated approvals. The primary challenge in utilizing BsAbs lies in patient selection due to variable responses, unique toxicity, and health economics. To date, no validated biomarkers of therapy response exist, however data demonstrating potential clinical, imaging, and biological markers relating to BsAbs are growing. This review examines current prognostic and potentially predictive biomarkers and explores future directions for nuanced patient selection.
Article Details
Authors (3)
Cameron S. Lewis
1Department of Hematology, Austin Health, Melbourne, Australia
Allison Barraclough
12Department of Haematology, Fiona Stanley Hospital, Murdoch, Australia
Eliza A. Hawkes
14Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia