Blood
Articles in this Issue
Persistent microbiome dysbiosis following hematopoietic cell transplantation: Gut GvHD as the most severe manifestation of microbial disruption
Abstract Background Hematopoietic cell transplantation conditioning regimens severely disrupt the gut microbiome, potent...
Daratumumab with dose-adjusted EPOCH feasibility and early efficacy in newly diagnosed plasmablastic lymphoma: AIDS malignancy consortium 105
Abstract Background: Plasmablastic lymphoma (PBL) is commonly associated with HIV, immunosuppression, old age, and autoimmune disorders, but...
Recombinant ADAMTS13 prophylaxis in patients with congenital thrombotic thrombocytopenic purpura: Final analysis from A phase 3 randomized, controlled study
Abstract Introduction Data from the final analysis of a phase 3 study (NCT03393975) that investigated the efficacy and s...
Pregnancy related complications and placenta pathology in pregnant women with sickle cell disease
Abstract Background: Among pregnant women with sickle cell disease (SCD), studies have shown an increased risk of complications such as mate...
Spatial communication modules identify prognostic cell-cell signaling hubs in chronic graft-versus-host disease
Abstract Introduction : Chronic graft-versus-host disease (GVHD) is a leading cause of late non-relapse mortality following allogeneic hemat...
Phenotype–Genotype characterization of inherited Protein C deficiency in a qatari family
Abstract Background Protein C deficiency is an autosomal dominant thrombophilia caused by pathogenic variants in the PROC gene. Heterozygous...
Allogeneic hematopoietic cell transplantation in TP53-mutated Acute Myeloid Leukemia patients with active disease: A study from the global committee and the acute leukemia working party of the EBMT
Abstract Background Acute myeloid leukemia (AML) harboring TP53 mutations is notoriously challenging to manage, frequently showing resistanc...
Expansion of human hematopoietic stem cells by inhibiting translation
Abstract Hematopoietic stem cell (HSC) transplantation using umbilical cord blood (UCB) is a potentially life-saving treatment for leukemia...
Dynamic crosstalk between CLL cells and lymph node fibroblasts promotes a pro-tumor microenvironment
Abstract Chronic lymphocytic leukemia (CLL) relies heavily on microenvironmental support within secondary lymphoid organs, especially lymph...
Polatuzumab-vedotin in large diffuse B-cell lymphoma: A multicenter observational study from Latin America (2020–2024)
Abstract Introduction: Polatuzumab vedotin (Pola), an anti-CD79b antibody-drug conjugate linked to monomethyl auristatin...
The fertility outcome in a cohort of SCD patients undergoing haploidentical allogeneic stem cell transplant using NMA regimen.
Abstract Abstract title: The fertility outcome in a cohort of SCD patients undergoing haploidentical allogeneic stem cell transplant using N...
Peripheral cytopenias and bone marrow findings in patients with liver failure: A ten-year retrospective analysis at a high-volume transplant center
Abstract Introduction: Peripheral blood abnormalities are a common occurrence in patients with chronic liver disease. Thrombocytopenia is of...
Novel criteria for evaluating early treatment response with whole body magnetic resonance imaging and prognostic implications in patients with newly diagnosed multiple myeloma
Abstract Introduction: Whole-body magnetic resonance imaging (WBMRI) is a highly sensitive technique to detect focal lesions in patients (pt...
Molecular and functional determinants of response to venetoclax and inotuzumab ozogamicin in CD22-positive ALL
Abstract Introduction: Venetoclax (VEN) is a selective BCL-2 inhibitor with clinical activity in subsets of patients with ALL (Del Gaizo Blo...
Impact of frailty in survival of older patients with classical Hodgkin lymphoma: A retrospective, multicenter study from the spanish registry of lymphoma (RELINF) of the spanish group of lymphoma (GELTAMO)
Abstract Introduction. The outcomes of older adults with classical Hodgkin Lymphoma (cHL) have improved in recent decades. However, despite...
Whole genome sequencing reveals that the Philadelphia chromosome (Ph) can evolve and gain complex chromoplectic sequence rearrangements associated with tyrosine kinase inhibitor (TKI) resistance
Abstract Background Understanding of the heterogeneity in the formation of the Ph has evolved as technology has advanced. In the pre-TKI era,...
RBC cultured from immortalized erythroblasts that express ectopic antigens induce antigen specific immune responses
Abstract Introduction: The exposure to foreign alloantigens upon pregnancy or after receiving red blood cell (RBC) trans...
A phase 2 Study of teclistamab in combination with daratumumab in elderly patients with newly diagnosed multiple myeloma: The IFM2021-01 teclille trial, cohort a
Abstract Background. Teclistamab is a subcutaneous bispecific IgG4 antibody targeting BCMA on myeloma cells and CD3 on T cells, enabling T-c...
Developing epigenetic synergistic drug combinations with albendazole in paediatric acute myeloid leukaemia
Abstract Acute myeloid leukaemia (AML) is an aggressive malignancy that account for ~25% of all paediatric cancers (Tebbi 2021). Over the la...
Efficacy and safety of bridging versus non-bridging chimeric antigen receptor t-cell therapy in relapsed/refractory diffuse large b-cell lymphoma : A systematic review and meta-analysis
Abstract Introduction:Chimeric antigen receptor T-cell (CART) therapy has become the standard of care for patients with relapsed/refractory...
Maintenance treatment with gilteritinib suppresses post-transplant relapse in relapsed/refractory FLT3-mutated acute myeloid leukemia: A Japanese nationwide registry study
Abstract Background: Gilteritinib, a FLT3 inhibitor, is widely used for relapse or refractory (R/R) FLT3-mutated acute myeloid leukemia (AML...
Efficacy and safety of tranexamic acid in non-haemophilia bleeding disorders: A systematic review of randomized controlled trials
Abstract BACKGROUND Tranexamic acid (TXA) is a synthetic antifibrinolytic agent widely used to reduce bleeding in surgical procedures, trauma...
In vitro microfluidics model revealed red blood cell derived extracellular vesicles cause second hit to heme-primed endothelial cells
Abstract Introduction: Sickle cell disease (SCD) is a genetic hemoglobinopathy associated with increased red blood cell (RBC) rigidity and s...
The role of xdh and hprt1 on purine metabolism in hematopoiesis and leukemia
Abstract In mammalian cells, purine metabolism is essential for nucleic acid synthesis, redox balance, and energy homeostasis, involving den...
Timing of tyrosine kinase inhibitor switching and long-term outcomes in chronic myeloid leukemia: A real-world comparative study
Abstract Background: In chronic myeloid leukemia (CML), switching tyrosine kinase inhibitors (TKIs) is often necessary due to intolerance, i...